6SST
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![BU of 6sst by Molmil](/molmil-images/mine/6sst) | cryo-em structure of alpha-synuclein fibril polymorph 2B | Descriptor: | Alpha-synuclein | Authors: | Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. | Deposit date: | 2019-09-09 | Release date: | 2019-12-18 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy. Elife, 8, 2019
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6T0O
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![BU of 6t0o by Molmil](/molmil-images/mine/6t0o) | Crystal structure of YTHDC1 with fragment 14 (ACA_DC1_004) | Descriptor: | 2-methyl-3~{H}-pyrido[3,4-d]pyrimidin-4-one, SULFATE ION, YTHDC1 | Authors: | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | Deposit date: | 2019-10-03 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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4AQH
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![BU of 4aqh by Molmil](/molmil-images/mine/4aqh) | Plasminogen activator inhibitor type-1 in complex with the inhibitor AZ3976 | Descriptor: | PLASMINOGEN ACTIVATOR INHIBITOR 1, TERT-BUTYL 3-[(4-OXO-3H-PYRIDO[2,3-D]PYRIMIDIN-2-YL)AMINO]AZETIDINE-1-CARBOXYLATE | Authors: | Fjellstrom, O, Deinum, J, Sjogren, T, Johansson, C, Geschwindner, S, Nerme, V, Legnehed, A, McPheat, J, Olsson, K, Bodin, C, Gustafsson, D. | Deposit date: | 2012-04-17 | Release date: | 2012-11-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Characterization of a Small Molecule Inhibitor of Plasminogen Activator Inhibitor Type 1 that Accelerates the Transition Into the Latent Conformation J.Biol.Chem., 288, 2013
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4DIQ
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![BU of 4diq by Molmil](/molmil-images/mine/4diq) | Crystal Structure of human NO66 | Descriptor: | Lysine-specific demethylase NO66, NICKEL (II) ION, PYRIDINE-2,4-DICARBOXYLIC ACID, ... | Authors: | Vollmar, M, Krojer, T, Ng, S, Pilka, E, Bray, J, Pike, A.C.W, Filippakopoulos, P, Roos, A, Arrowsmith, C.H, Edwards, E, Bountra, C, von Delft, F, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2012-01-31 | Release date: | 2012-03-07 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of human NO66 TO BE PUBLISHED
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8K77
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![BU of 8k77 by Molmil](/molmil-images/mine/8k77) | Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and brivaracetam | Descriptor: | (2S)-2-[(4R)-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yamagata, A. | Deposit date: | 2023-07-26 | Release date: | 2024-05-01 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A. Nat Commun, 15, 2024
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7KES
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![BU of 7kes by Molmil](/molmil-images/mine/7kes) | Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, mutant H168A in complex with apramycin and CoA | Descriptor: | APRAMYCIN, Aminoglycoside N(3)-acetyltransferase, CHLORIDE ION, ... | Authors: | Stogios, P.J, Skarina, T, Michalska, K, Xu, Z, Yim, V, Savchenko, A, Joachimiak, A, Satchell, K.J, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-10-12 | Release date: | 2020-10-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family. Commun Biol, 5, 2022
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2HD6
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![BU of 2hd6 by Molmil](/molmil-images/mine/2hd6) | Crystal structure of the human carbonic anhydrase II in complex with a hypoxia-activatable sulfonamide. | Descriptor: | CHLORIDE ION, Carbonic anhydrase 2, GLYCEROL, ... | Authors: | De Simone, G, Vitale, R.M, Di Fiore, A, Pedone, C. | Deposit date: | 2006-06-20 | Release date: | 2006-10-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX. J.Med.Chem., 49, 2006
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7K5H
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![BU of 7k5h by Molmil](/molmil-images/mine/7k5h) | 1.90 A resolution structure of WT BfrB from Pseudomonas aeruginosa in complex with a protein-protein interaction inhibitor KM-5-66 | Descriptor: | 4-{[3-(3-chloro-5-hydroxyphenyl)propyl]amino}-1H-isoindole-1,3(2H)-dione, Ferroxidase, POTASSIUM ION, ... | Authors: | Lovell, S, Battaile, K.P, Soldano, A, Punchi-Hewage, A, Meraz, K, Annor-Gyamfi, J.K, Yao, H, Bunce, R.A, Rivera, M. | Deposit date: | 2020-09-16 | Release date: | 2020-12-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Small Molecule Inhibitors of the Bacterioferritin (BfrB)-Ferredoxin (Bfd) Complex Kill Biofilm-Embedded Pseudomonas aeruginosa Cells. Acs Infect Dis., 7, 2021
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5WX8
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![BU of 5wx8 by Molmil](/molmil-images/mine/5wx8) | Human herpesvirus 6A immediate early protein 2 C-terminal domain | Descriptor: | Immediate-early protein 2 | Authors: | Nishimura, M, Wang, J, Wakata, A, Sakamoto, K, Mori, Y. | Deposit date: | 2017-01-06 | Release date: | 2017-08-02 | Last modified: | 2017-12-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of the DNA-Binding Domain of Human Herpesvirus 6A Immediate Early Protein 2. J. Virol., 91, 2017
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6SZ8
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![BU of 6sz8 by Molmil](/molmil-images/mine/6sz8) | Crystal structure of YTHDC1 with fragment 6 (DHU_DC1_034) | Descriptor: | 6-pyrrolidin-1-yl-5~{H}-pyrimidine-2,4-dione, SULFATE ION, YTH domain-containing protein 1 | Authors: | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | Deposit date: | 2019-10-02 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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8KCQ
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![BU of 8kcq by Molmil](/molmil-images/mine/8kcq) | Solution structures of the N-terminal divergent caplonin homology (NN-CH) domains of human intraflagellar transport protein 54 | Descriptor: | TRAF3-interacting protein 1 | Authors: | Dang, W, Kuwasako, K, He, F, Takahashi, M, Tsuda, K, Nagata, T, Tanaka, A, Kobayashi, N, Kigawa, T, Guentert, P, Shirouzu, M, Yokoyama, S, Muto, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2023-08-08 | Release date: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | 1 H, 13 C, and 15 N resonance assignments and solution structure of the N-terminal divergent calponin homology (NN-CH) domain of human intraflagellar transport protein 54. Biomol.Nmr Assign., 18, 2024
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6SZN
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![BU of 6szn by Molmil](/molmil-images/mine/6szn) | Crystal structure of YTHDC1 with fragment 8 (DHU_DC1_006) | Descriptor: | N-carbamoylbenzamide, SULFATE ION, YTH domain-containing protein 1 | Authors: | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | Deposit date: | 2019-10-02 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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5WY1
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![BU of 5wy1 by Molmil](/molmil-images/mine/5wy1) | Crystal structure of mouse DNA methyltransferase 1 (T1505A mutant) | Descriptor: | DNA (cytosine-5)-methyltransferase 1, ZINC ION | Authors: | Kanada, K, Takeshita, K, Suetake, I, Tajima, S, Nakagawa, A. | Deposit date: | 2017-01-10 | Release date: | 2017-05-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.27 Å) | Cite: | Conserved threonine 1505 in the catalytic domain stabilizes mouse DNA methyltransferase 1 J. Biochem., 162, 2017
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5WSX
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![BU of 5wsx by Molmil](/molmil-images/mine/5wsx) | The crystal structure of SAV606 | Descriptor: | Uncharacterized protein | Authors: | Chisuga, T, Miyanaga, A, Kudo, F, Eguchi, T. | Deposit date: | 2016-12-08 | Release date: | 2017-05-31 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural analysis of the dual-function thioesterase SAV606 unravels the mechanism of Michael addition of glycine to an alpha , beta-unsaturated thioester. J. Biol. Chem., 292, 2017
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6SSX
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![BU of 6ssx by Molmil](/molmil-images/mine/6ssx) | cryo-em structure of alpha-synuclein fibril polymorph 2A | Descriptor: | Alpha-synuclein | Authors: | Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. | Deposit date: | 2019-09-09 | Release date: | 2019-12-18 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy. Elife, 8, 2019
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5X1K
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![BU of 5x1k by Molmil](/molmil-images/mine/5x1k) | Vanillate/3-O-methylgallate O-demethylase, LigM, 3-O-methylgallate complex form | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-methoxy-4,5-bis(oxidanyl)benzoic acid, ... | Authors: | Harada, A, Senda, T. | Deposit date: | 2017-01-26 | Release date: | 2017-05-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The crystal structure of a new O-demethylase from Sphingobium sp. strain SYK-6 FEBS J., 284, 2017
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4AK2
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![BU of 4ak2 by Molmil](/molmil-images/mine/4ak2) | Structure of BT4661, a SusE-like surface located polysaccharide binding protein from the Bacteroides thetaiotaomicron heparin utilisation locus | Descriptor: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, BT_4661, SODIUM ION | Authors: | Lowe, E.C, Basle, A, Czjzek, M, Thomas, S, Murray, H, Firbank, S.J, Bolam, D.N. | Deposit date: | 2012-02-21 | Release date: | 2013-03-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6TZ9
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![BU of 6tz9 by Molmil](/molmil-images/mine/6tz9) | |
6TVO
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![BU of 6tvo by Molmil](/molmil-images/mine/6tvo) | Human CRM1-RanGTP in complex with Leptomycin B | Descriptor: | Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Shaikhqasem, A, Ficner, R. | Deposit date: | 2020-01-10 | Release date: | 2020-07-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.201 Å) | Cite: | Characterization of Inhibition Reveals Distinctive Properties for Human andSaccharomyces cerevisiaeCRM1. J.Med.Chem., 63, 2020
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5WX2
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![BU of 5wx2 by Molmil](/molmil-images/mine/5wx2) | Crystal structure of porcine kidney D-amino acid oxidase mutant (I230A/R283G) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Motojima, F, Yasukawa, K, Ohno, A, Asano, Y. | Deposit date: | 2017-01-06 | Release date: | 2018-01-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Tailoring D-amino acid oxidase from the pid kidney to R-stereoselective amine oxidase and its use in the deracemization of 4-chlorobenzhydrylamine To Be Published
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8JVG
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![BU of 8jvg by Molmil](/molmil-images/mine/8jvg) | Crystal structure of dephospho-coenzyme A kinase | Descriptor: | GTP-dependent dephospho-CoA kinase | Authors: | Kita, A, Ishida, Y, Shimosaka, T, Michimori, Y, Makarova, K, Koonin, E, Atomi, H, Miki, K. | Deposit date: | 2023-06-28 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of GTP-dependent dephospho-coenzyme A kinase from the hyperthermophilic archaeon, Thermococcus kodakarensis. Proteins, 92, 2024
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8JVC
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![BU of 8jvc by Molmil](/molmil-images/mine/8jvc) | Crystal structure of dephospho-coenzyme A kinase | Descriptor: | GTP-dependent dephospho-CoA kinase | Authors: | Kita, A, Ishida, Y, Shimosaka, T, Michimori, Y, Makarova, K, Koonin, E, Atomi, H, Miki, K. | Deposit date: | 2023-06-28 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structure of GTP-dependent dephospho-coenzyme A kinase from the hyperthermophilic archaeon, Thermococcus kodakarensis. Proteins, 92, 2024
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5WUT
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![BU of 5wut by Molmil](/molmil-images/mine/5wut) | |
8JVF
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![BU of 8jvf by Molmil](/molmil-images/mine/8jvf) | Crystal structure of dephospho-coenzyme A kinase | Descriptor: | GTP-dependent dephospho-CoA kinase, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | Authors: | Kita, A, Ishida, Y, Shimosaka, T, Michimori, Y, Makarova, K, Koonin, E, Atomi, H, Miki, K. | Deposit date: | 2023-06-28 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of GTP-dependent dephospho-coenzyme A kinase from the hyperthermophilic archaeon, Thermococcus kodakarensis. Proteins, 92, 2024
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5WWV
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![BU of 5wwv by Molmil](/molmil-images/mine/5wwv) | Crystal structure of porcine kidney D-amino acid oxidase mutant (I230A/R283G) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, (S)-(4-chlorophenyl)-phenyl-methanamine, D-amino-acid oxidase, ... | Authors: | Motojima, F, Yasukawa, K, Ohno, A, Asano, Y. | Deposit date: | 2017-01-05 | Release date: | 2018-01-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Tailoring D-amino acid oxidase from the pid kidney to R-stereoselective amine oxidase and its use in the deracemization of 4-chlorobenzhydrylamine To Be Published
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