4YOX
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4YOV
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4YOY
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4YOW
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6K72
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![BU of 6k72 by Molmil](/molmil-images/mine/6k72) | eIF2(aP) - eIF2B complex | Descriptor: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 subunit 3, ... | Authors: | Kashiwagi, K, Yokoyama, T, Ito, T. | Deposit date: | 2019-06-05 | Release date: | 2019-07-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structural basis for eIF2B inhibition in integrated stress response. Science, 364, 2019
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6K71
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![BU of 6k71 by Molmil](/molmil-images/mine/6k71) | eIF2 - eIF2B complex | Descriptor: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 subunit 3, ... | Authors: | Kashiwagi, K, Yokoyama, T, Ito, T. | Deposit date: | 2019-06-05 | Release date: | 2019-07-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural basis for eIF2B inhibition in integrated stress response. Science, 364, 2019
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6JLZ
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![BU of 6jlz by Molmil](/molmil-images/mine/6jlz) | P-eIF2a - eIF2B complex | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, PHOSPHATE ION, Probable translation initiation factor eIF-2B subunit beta, ... | Authors: | Kashiwagi, K, Ito, T. | Deposit date: | 2019-03-07 | Release date: | 2019-05-01 | Last modified: | 2019-05-15 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Structural basis for eIF2B inhibition in integrated stress response. Science, 364, 2019
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6JLY
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![BU of 6jly by Molmil](/molmil-images/mine/6jly) | eIF2a - eIF2B complex | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, PHOSPHATE ION, Probable translation initiation factor eIF-2B subunit beta, ... | Authors: | Kashiwagi, K, Ito, T. | Deposit date: | 2019-03-07 | Release date: | 2019-05-01 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural basis for eIF2B inhibition in integrated stress response. Science, 364, 2019
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3VRH
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![BU of 3vrh by Molmil](/molmil-images/mine/3vrh) | Crystal structure of ph0300 | Descriptor: | BICINE, Putative uncharacterized protein PH0300, ZINC ION | Authors: | Nakagawa, H, Kuratani, M, Goto-Ito, S, Ito, T, Sekine, S.I, Yokoyama, S. | Deposit date: | 2012-04-10 | Release date: | 2013-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystallographic and mutational studies on the tRNA thiouridine synthetase TtuA. Proteins, 2013
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2YX1
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![BU of 2yx1 by Molmil](/molmil-images/mine/2yx1) | Crystal structure of M.jannaschii tRNA m1G37 methyltransferase | Descriptor: | Hypothetical protein MJ0883, SINEFUNGIN, ZINC ION | Authors: | Goto-Ito, S, Ito, T, Ishii, R, Bessho, Y, Yokoyama, S. | Deposit date: | 2007-04-23 | Release date: | 2008-04-22 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of archaeal tRNA(m(1)G37)methyltransferase aTrm5. Proteins, 72, 2008
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1Q1O
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![BU of 1q1o by Molmil](/molmil-images/mine/1q1o) | Solution Structure of the PB1 Domain of Cdc24p (Long Form) | Descriptor: | Cell division control protein 24 | Authors: | Yoshinaga, S, Kohjima, M, Ogura, K, Yokochi, M, Takeya, R, Ito, T, Sumimoto, H, Inagaki, F. | Deposit date: | 2003-07-22 | Release date: | 2003-10-14 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The PB1 domain and the PC motif-containing region are structurally similar protein binding modules EMBO J., 22, 2003
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3ECS
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![BU of 3ecs by Molmil](/molmil-images/mine/3ecs) | Crystal structure of human eIF2B alpha | Descriptor: | CHLORIDE ION, SULFATE ION, Translation initiation factor eIF-2B subunit alpha | Authors: | Hiyama, T.B, Ito, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2008-09-01 | Release date: | 2009-09-01 | Last modified: | 2014-02-05 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Crystal structure of the alpha subunit of human translation initiation factor 2B J.Mol.Biol., 392, 2009
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2ZZN
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![BU of 2zzn by Molmil](/molmil-images/mine/2zzn) | The complex structure of aTrm5 and tRNACys | Descriptor: | MAGNESIUM ION, RNA (71-MER), S-ADENOSYLMETHIONINE, ... | Authors: | Goto-Ito, S, Ito, T, Yokoyama, S. | Deposit date: | 2009-02-19 | Release date: | 2009-09-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation. Nat.Struct.Mol.Biol., 16, 2009
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2YX0
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![BU of 2yx0 by Molmil](/molmil-images/mine/2yx0) | Crystal structure of P. horikoshii TYW1 | Descriptor: | radical sam enzyme | Authors: | Goto-Ito, S, Ishii, R, Ito, T, Shibata, R, Fusatomi, E, Sekine, S, Bessho, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-23 | Release date: | 2007-10-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structure of an archaeal TYW1, the enzyme catalyzing the second step of wye-base biosynthesis Acta Crystallogr.,Sect.D, 63, 2007
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2ZZM
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![BU of 2zzm by Molmil](/molmil-images/mine/2zzm) | The complex structure of aTrm5 and tRNALeu | Descriptor: | MAGNESIUM ION, RNA (84-MER), S-ADENOSYLMETHIONINE, ... | Authors: | Goto-Ito, S, Ito, T, Yokoyama, S. | Deposit date: | 2009-02-19 | Release date: | 2009-09-15 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation Nat.Struct.Mol.Biol., 16, 2009
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1TZ1
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![BU of 1tz1 by Molmil](/molmil-images/mine/1tz1) | Solution structure of the PB1 domain of CDC24P (short form) | Descriptor: | Cell division control protein 24 | Authors: | Yoshinaga, S, Terasawa, H, Ogura, K, Noda, Y, Ito, T, Sumimoto, H, Inagaki, F. | Deposit date: | 2004-07-09 | Release date: | 2005-09-06 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the PB1 domain of CDC24P (short form) To be Published
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5B41
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![BU of 5b41 by Molmil](/molmil-images/mine/5b41) | Crystal structure of VDR-LBD complexed with 2-methylidene-19-nor-1a,25-dihydroxyvitamin D3 | Descriptor: | (1R,3R)-5-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-2- methylenecyclohexane-1,3-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | Authors: | Anami, Y, Itoh, T, Yamamoto, K. | Deposit date: | 2016-03-23 | Release date: | 2016-12-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Apo- and Antagonist-Binding Structures of Vitamin D Receptor Ligand-Binding Domain Revealed by Hybrid Approach Combining Small-Angle X-ray Scattering and Molecular Dynamics J.Med.Chem., 59, 2016
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3AFR
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![BU of 3afr by Molmil](/molmil-images/mine/3afr) | Crystal Structure of VDR-LBD/22S-Butyl-1a,24R-dihydroxyvitamin D3 complex | Descriptor: | (1R,3S,5Z)-5-[(2E)-2-{(1R,3aS,7aR)-1-[(1R,2S,4R)-2-butyl-4-hydroxy-1,5-dimethylhexyl]-7a-methyloctahydro-4H-inden-4-yli dene}ethylidene]-4-methylidenecyclohexane-1,3-diol, 13-meric peptide from Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | Authors: | Inaba, Y, Nakabayashi, M, Itoh, T, Ikura, T, Ito, N, Yamamoto, K. | Deposit date: | 2010-03-10 | Release date: | 2010-03-31 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | 22S-Butyl-1alpha,24R-dihydroxyvitamin D(3): Recovery of vitamin D receptor agonistic activity J.Steroid Biochem.Mol.Biol., 121, 2010
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1IPG
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![BU of 1ipg by Molmil](/molmil-images/mine/1ipg) | SOLUTION STRUCTURE OF THE PB1 DOMAIN OF BEM1P | Descriptor: | BEM1 PROTEIN | Authors: | Terasawa, H, Noda, Y, Ito, T, Hatanaka, H, Ichikawa, S, Ogura, K, Sumimoto, H, Inagaki, F. | Deposit date: | 2001-05-14 | Release date: | 2001-08-15 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structure and ligand recognition of the PB1 domain: a novel protein module binding to the PC motif. EMBO J., 20, 2001
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1IP9
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![BU of 1ip9 by Molmil](/molmil-images/mine/1ip9) | SOLUTION STRUCTURE OF THE PB1 DOMAIN OF BEM1P | Descriptor: | BEM1 PROTEIN | Authors: | Terasawa, H, Noda, Y, Ito, T, Hatanaka, H, Ichikawa, S, Ogura, K, Sumimoto, H, Inagaki, F. | Deposit date: | 2001-04-26 | Release date: | 2001-08-15 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structure and ligand recognition of the PB1 domain: a novel protein module binding to the PC motif. EMBO J., 20, 2001
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7F67
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![BU of 7f67 by Molmil](/molmil-images/mine/7f67) | eIF2B-SFSV NSs-2-eIF2 | Descriptor: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 3, Non-structural protein NS-S, ... | Authors: | Kashiwagi, K, Ito, T. | Deposit date: | 2021-06-24 | Release date: | 2021-12-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | eIF2B-capturing viral protein NSs suppresses the integrated stress response. Nat Commun, 12, 2021
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7F66
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![BU of 7f66 by Molmil](/molmil-images/mine/7f66) | eIF2B-SFSV NSs-1-eIF2 | Descriptor: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 3, Non-structural protein NS-S, ... | Authors: | Kashiwagi, K, Ito, T. | Deposit date: | 2021-06-24 | Release date: | 2021-12-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | eIF2B-capturing viral protein NSs suppresses the integrated stress response. Nat Commun, 12, 2021
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7F64
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![BU of 7f64 by Molmil](/molmil-images/mine/7f64) | eIF2B-SFSV NSs | Descriptor: | Non-structural protein NS-S, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | Authors: | Kashiwagi, K, Ito, T. | Deposit date: | 2021-06-24 | Release date: | 2021-12-08 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.42 Å) | Cite: | eIF2B-capturing viral protein NSs suppresses the integrated stress response. Nat Commun, 12, 2021
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3WTQ
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![BU of 3wtq by Molmil](/molmil-images/mine/3wtq) | Crystal structure of VDR-LBD complexed with 22S-butyl-2-methylidene-19-nor-1a,25-dihydroxyvitamin D3 | Descriptor: | (1R,3R,7E,17beta)-17-[(2R,3S)-3-butyl-6-hydroxy-6-methylheptan-2-yl]-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | Authors: | Nakabayashi, M, Inaba, Y, Itoh, T, Anami, Y, Ikura, T, Ito, N, Yamamoto, K. | Deposit date: | 2014-04-15 | Release date: | 2015-04-15 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of VDR-LBD complexed with 22S-butyl-2-methylidene-19-nor-1a,25-dihydroxyvitamin D3 To be Published
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7F5S
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![BU of 7f5s by Molmil](/molmil-images/mine/7f5s) | human delta-METTL18 60S ribosome | Descriptor: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | Authors: | Takahashi, M, Kashiwagi, K, Ito, T. | Deposit date: | 2021-06-22 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (2.72 Å) | Cite: | METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance. Elife, 11, 2022
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