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Factor Xa in complex with the inhibitor 4-[(5-chloroindol-2-yl)sulfonyl]-2-(2-methylpropyl)-1-[[5-(pyridin-4-yl) pyrimidin-2-yl]carbonyl]piperazine
Descriptor:	5-CHLORO-2-({3-ISOBUTYL-4-[(5-PYRIDIN-4-YLPYRIMIDIN-2-YL)CARBONYL]PIPERAZIN-1-YL}SULFONYL)-1H-INDOLE, CALCIUM ION, Coagulation factor X, ...
Authors:	Suzuki, M.
Deposit date:	2004-11-29
Release date:	2005-11-29
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites Bioorg.Med.Chem., 13, 2005

1UMA

ALPHA-THROMBIN (HIRUGEN) COMPLEXED WITH NA-(N,N-DIMETHYLCARBAMOYL)-ALPHA-AZALYSINE
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN, HIRUDIN I, ...
Authors:	Nardini, M, Pesce, A, Rizzi, M, Casale, E, Ferraccioli, R, Balliano, G, Milla, P, Ascenzi, P, Bolognesi, M.
Deposit date:	1996-03-26
Release date:	1996-11-08
Last modified:	2024-10-09
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study. J.Mol.Biol., 258, 1996

1XKB

FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID
Descriptor:	(2S)-(3'-AMIDINO-3-BIPHENYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID, BLOOD COAGULATION FACTOR XA, CALCIUM ION
Authors:	Kamata, K, Kim, S.H.
Deposit date:	1998-03-19
Release date:	1999-03-23
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Structural basis for chemical inhibition of human blood coagulation factor Xa. Proc.Natl.Acad.Sci.USA, 95, 1998

1V3X

Factor Xa in complex with the inhibitor 1-[6-methyl-4,5,6,7-tetrahydrothiazolo(5,4-c)pyridin-2-yl] carbonyl-2-carbamoyl-4-(6-chloronaphth-2-ylsulphonyl)piperazine
Descriptor:	(2R)-4-[(6-CHLORO-2-NAPHTHYL)SULFONYL]-1-[(5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-YL)CARBONYL]PIPERAZ INE-2-CARBOXAMIDE, CALCIUM ION, Coagulation factor X, ...
Authors:	Suzuki, M.
Deposit date:	2003-11-07
Release date:	2004-11-07
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Synthesis and conformational analysis of a non-amidine factor Xa inhibitor that incorporates 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 binding element J.Med.Chem., 47, 2004

1XKA

FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID
Descriptor:	(2S)-(3'-AMIDINO-3-BIPHENYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID, BLOOD COAGULATION FACTOR XA, CALCIUM ION
Authors:	Kamata, K, Kim, S.H.
Deposit date:	1998-03-19
Release date:	1999-03-23
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Structural basis for chemical inhibition of human blood coagulation factor Xa. Proc.Natl.Acad.Sci.USA, 95, 1998

1B2M

THREE-DIMENSIONAL STRUCTURE OF RIBONULCEASE T1 COMPLEXED WITH AN ISOSTERIC PHOSPHONATE ANALOGUE OF GPU: ALTERNATE SUBSTRATE BINDING MODES AND CATALYSIS.
Descriptor:	5'-R(GP(U34))-3', RIBONUCLEASE T1
Authors:	Arni, R.K, Watanabe, L, Ward, R.J, Kreitman, R.J, Kumar, K, Walz Jr, F.G.
Deposit date:	1998-11-27
Release date:	1999-03-25
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Three-dimensional structure of ribonuclease T1 complexed with an isosteric phosphonate substrate analogue of GpU: alternate substrate binding modes and catalysis. Biochemistry, 38, 1999

1FPH

THE INTERACTION OF THROMBIN WITH FIBRINOGEN: A STRUCTURAL BASIS FOR ITS SPECIFICITY
Descriptor:	ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), FIBRINOPEPTIDE A, ...
Authors:	Stubbs, M.T, Bode, W.
Deposit date:	1993-04-21
Release date:	1994-01-31
Last modified:	2024-10-09
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	The interaction of thrombin with fibrinogen. A structural basis for its specificity. Eur.J.Biochem., 206, 1992

1DWE

Crystallographic analysis at 3.0-Angstroms resolution of the binding to human thrombin of four active site-directed inhibitors
Descriptor:	ALPHA-THROMBIN heavy chain, ALPHA-THROMBIN light chain, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ...
Authors:	Banner, D.W, Hadvary, P.
Deposit date:	1992-08-19
Release date:	1994-01-31
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

1DWB

CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
Descriptor:	ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), BENZAMIDINE, ...
Authors:	Banner, D.W, Hadvary, P.
Deposit date:	1992-08-19
Release date:	1994-01-31
Last modified:	2024-06-05
Method:	X-RAY DIFFRACTION (3.16 Å)
Cite:	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

1DWD

CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
Descriptor:	1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimidoyl-D-phenylalanyl]piperidine, ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), ...
Authors:	Banner, D.W, Hadvary, P.
Deposit date:	1992-08-19
Release date:	1994-01-31
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

1DWC

CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
Descriptor:	ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUDIN IIIA, ...
Authors:	Banner, D.W, Hadvary, P.
Deposit date:	1992-08-19
Release date:	1994-01-31
Last modified:	2024-06-05
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

1MTU

FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
Descriptor:	(+)-2-[4-[(-1-ACETIMIDOYL-4-PIPERIDINYL)OXY]-3-(7-AMIDINO-2-NAPHTHYL)PROPIONIC ACID, CALCIUM ION, TRYPSIN
Authors:	Stubbs, M.T.
Deposit date:	1997-05-16
Release date:	1997-11-12
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin. FEBS Lett., 375, 1995

1MTW

FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
Descriptor:	(2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-[4-({(3R)-1-[(1Z)-ethanimidoyl]pyrrolidin-3-yl}oxy)phenyl]propanoic acid, CALCIUM ION, TRYPSIN
Authors:	Stubbs, M.T.
Deposit date:	1997-05-16
Release date:	1997-11-12
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin. FEBS Lett., 375, 1995

1MTV

FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
Descriptor:	(+)-2-[4-[(-1-ACETIMIDOYL-4-PIPERIDINYL)OXY]-3-(7-AMIDINO-2-NAPHTHYL)PROPIONIC ACID, CALCIUM ION, TRYPSIN
Authors:	Stubbs, M.T.
Deposit date:	1997-05-16
Release date:	1997-11-12
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin. FEBS Lett., 375, 1995

1MTS

FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN
Descriptor:	(+)-2-[4-[(-1-ACETIMIDOYL-4-PIPERIDINYL)OXY]-3-(7-AMIDINO-2-NAPHTHYL)PROPIONIC ACID, CALCIUM ION, TRYPSIN
Authors:	Stubbs, M.T.
Deposit date:	1997-05-16
Release date:	1997-08-20
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin. FEBS Lett., 375, 1995

1QB1

Bovine Trypsin with 1-[2-[5-[amino(imino)methyl]-2-hydroxyphenoxy]-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]piperidine-3-carboxylic Acid (ZK-806974)
Descriptor:	1-[2-[5-[AMINO(IMINO)METHYL]-2-HYDROXYPHENOXY]-6-[3-(4,5-DIHYDRO-1-METHYL-1H-IMIDAZOL-2-YL)PHENOXY] PYRIDIN-4-YL]PIPERIDINE-3-CARBOXYLIC ACID, CALCIUM ION, PROTEIN (TRYPSIN)
Authors:	Whitlow, M.
Deposit date:	1999-04-28
Release date:	2000-04-29
Last modified:	2018-01-24
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin. Acta Crystallogr.,Sect.D, 55, 1999

1TFX

COMPLEX OF THE SECOND KUNITZ DOMAIN OF TISSUE FACTOR PATHWAY INHIBITOR WITH PORCINE TRYPSIN
Descriptor:	CALCIUM ION, TISSUE FACTOR PATHWAY INHIBITOR, TRYPSIN
Authors:	Stubbs, M.T, Huber, R.
Deposit date:	1997-01-21
Release date:	1998-01-21
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa. J.Mol.Biol., 269, 1997

1ADZ

THE SOLUTION STRUCTURE OF THE SECOND KUNITZ DOMAIN OF TISSUE FACTOR PATHWAY INHIBITOR, NMR, 30 STRUCTURES
Descriptor:	TISSUE FACTOR PATHWAY INHIBITOR
Authors:	Burgering, M.J.M, Orbons, L.P.M.
Deposit date:	1997-02-19
Release date:	1998-02-25
Last modified:	2024-10-30
Method:	SOLUTION NMR
Cite:	The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa. J.Mol.Biol., 269, 1997

1IQG

Human coagulation factor Xa in complex with M55159
Descriptor:	4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[4-HYDROXYIMINOMETHYL-1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQN

Human coagulation factor Xa in complex with M55192
Descriptor:	4-[[4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-6-OXO-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]-2-PIPERAZINYL]CARBONYL]MORPHOLINE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2024-11-06
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQH

Human coagulation factor Xa in complex with M55143
Descriptor:	4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[4-HYDROXYMETHYL-1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQI

Human coagulation factor Xa in complex with M55125
Descriptor:	4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL] METHYL]-2-PIPERAZINECARBOXYLIC ACID, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IOE

Human coagulation factor Xa in complex with M55532
Descriptor:	(-)-7-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]TETRAHYDRO-8A-(METHOXYMETHYL)-1'-(4-PYRIDINYL)-SPIRO[5H-OXAZOLO[3,2-A]PYRAZINE-2(3H),4'-PIPERIDIN]-5-ONE, CALCIUM ION, COAGULATION FACTOR XA
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-03-08
Release date:	2003-09-23
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Factor Xa Specific Inhibitor That Induces the Novel Binding Model In Complex With Human FXa To be Published

1IQF

Human coagulation factor Xa in complex with M55165
Descriptor:	(2R)-4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-6-OXO-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]-2-PIPERAZINECARBOXYLIC ACID ETHYL ESTER, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (3.2 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQL

Human coagulation factor Xa in complex with M54476
Descriptor:	4-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

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