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3CFN
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BU of 3cfn by Molmil
Crystal structure of human transthyretin in complex with 1-anilino-8-naphthalene sulfonate
Descriptor: 8-ANILINO-1-NAPHTHALENE SULFONATE, Transthyretin
Authors:Lima, L.-M.T.R, Foguel, D, Polikarpov, I.
Deposit date:2008-03-04
Release date:2009-03-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Identification of a novel ligand binding motif in the transthyretin channel.
Bioorg.Med.Chem., 18, 2010
3CFQ
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BU of 3cfq by Molmil
Crystal structure of human wild-type transthyretin in complex with diclofenac
Descriptor: 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, Transthyretin
Authors:Lima, L.-M.T.R, Foguel, D, Polikarpov, I.
Deposit date:2008-03-04
Release date:2009-03-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Identification of a novel ligand binding motif in the transthyretin channel.
Bioorg.Med.Chem., 18, 2010
3G9V
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BU of 3g9v by Molmil
Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22
Descriptor: Interleukin 22 receptor, alpha 2, Interleukin-22
Authors:de Moura, P.R, Watanabe, L, Bleicher, L, Colau, D, Renauld, J.-C, Polikarpov, I.
Deposit date:2009-02-14
Release date:2009-04-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.756 Å)
Cite:Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22
FEBS Lett., 583, 2009
3EXD
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BU of 3exd by Molmil
Sulfur-SAD phased HEWL Crystal
Descriptor: Lysozyme C
Authors:Nascimento, A.S, Liberato, M.V, Polikarpov, I.
Deposit date:2008-10-16
Release date:2008-10-28
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:The MX2 macromolecular crystallography beamline: a wiggler X-ray source at the LNLS.
J.Synchrotron Radiat., 16, 2009
1B8E
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BU of 1b8e by Molmil
HIGH RESOLUTION CRYSTAL STRUCTURE OF THE BOVINE BETA-LACTOGLOBULIN (ISOFORMS A AND B) IN ORTHOROMBIC SPACE GROUP
Descriptor: PROTEIN (BETA-LACTOGLOBULIN)
Authors:Oliveira, K.M.G, Sawyer, L, Polikarpov, I.
Deposit date:1999-01-30
Release date:2001-05-02
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structures of bovine beta-lactoglobulin in the orthorhombic space group C222(1). Structural differences between genetic variants A and B and features of the Tanford transition.
Eur.J.Biochem., 268, 2001
1DN0
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BU of 1dn0 by Molmil
STRUCTURE OF THE FAB FRAGMENT FROM A HUMAN IGM COLD AGGLUTININ
Descriptor: IGM-KAPPA COLD AGGLUTININ (HEAVY CHAIN), IGM-KAPPA COLD AGGLUTININ (LIGHT CHAIN)
Authors:Cauerhff, A, Braden, B, Carvalho, J.G, Leoni, J, Polikarpov, I, Goldbaum, F.
Deposit date:1999-12-15
Release date:2001-01-24
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Three-dimensional structure of the Fab from a human IgM cold agglutinin.
J.Immunol., 165, 2000
3GWS
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BU of 3gws by Molmil
Crystal Structure of T3-Bound Thyroid Hormone Receptor
Descriptor: 3,5,3'TRIIODOTHYRONINE, Thyroid hormone receptor beta
Authors:Nascimento, A.S, Dias, S.M.G, Nunes, F.M, Aparicio, R, Polikarpov, I, Baxter, J.D, Webb, P.
Deposit date:2009-04-01
Release date:2009-04-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function
J.Mol.Biol., 360, 2006
3HDL
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BU of 3hdl by Molmil
Crystal Structure of Highly Glycosylated Peroxidase from Royal Palm Tree
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Watanabe, L, Moura, P.R, Bleicher, L, Nascimento, A.S, Zamorano, L.S, Calvete, J.J, Bursakov, S, Roig, M.G, Shnyrov, V.L, Polikarpov, I.
Deposit date:2009-05-07
Release date:2009-11-24
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure and statistical coupling analysis of highly glycosylated peroxidase from royal palm tree (Roystonea regia).
J.Struct.Biol., 169, 2010
3ILN
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BU of 3iln by Molmil
X-ray structure of the laminarinase from Rhodothermus marinus
Descriptor: CALCIUM ION, GLYCEROL, Laminarinase
Authors:Bleicher, L, Golubev, A, Rojas, A.L, Nascimento, A.S, Polikarpov, I.
Deposit date:2009-08-07
Release date:2010-08-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular basis of the thermostability and thermophilicity of laminarinases: X-ray structure of the hyperthermostable laminarinase from Rhodothermus marinus and molecular dynamics simulations.
J.Phys.Chem.B, 115, 2011
3HZF
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BU of 3hzf by Molmil
Structure of TR-alfa bound to selective thyromimetic GC-1 in C2 space group
Descriptor: Thyroid hormone receptor, alpha isoform 1 variant, {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid
Authors:Aparicio, R, Bleicher, L, Polikarpov, I.
Deposit date:2009-06-23
Release date:2009-07-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms.
Bmc Struct.Biol., 8, 2008
1QFE
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BU of 1qfe by Molmil
THE STRUCTURE OF TYPE I 3-DEHYDROQUINATE DEHYDRATASE FROM SALMONELLA TYPHI
Descriptor: 3-AMINO-4,5-DIHYDROXY-CYCLOHEX-1-ENECARBOXYLATE, PROTEIN (3-DEHYDROQUINATE DEHYDRATASE)
Authors:Shrive, A.K, Polikarpov, I, Sawyer, L, Coggins, J.R, Hawkins, A.R.
Deposit date:1999-04-05
Release date:2000-04-05
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction.
Nat.Struct.Biol., 6, 1999
1QG5
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BU of 1qg5 by Molmil
HIGH RESOLUTION CRYSTAL STRUCTURE OF THE BOVINE BETA-LACTOGLOBULIN (ISOFORM A)
Descriptor: BETA-LACTOGLOBULIN
Authors:Oliveira, K.M.G, Sawyer, L, Polikarpov, I.
Deposit date:1999-04-20
Release date:2001-04-21
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of bovine beta-lactoglobulin in the orthorhombic space group C222(1). Structural differences between genetic variants A and B and features of the Tanford transition.
Eur.J.Biochem., 268, 2001
3I36
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BU of 3i36 by Molmil
Crystal Structure of Rat Protein Tyrosine Phosphatase eta Catalytic Domain
Descriptor: CHLORIDE ION, Vascular protein tyrosine phosphatase 1
Authors:Nascimento, A.S, Matozo, H.C, Santos, M.A, Polikarpov, I.
Deposit date:2009-06-30
Release date:2010-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.841 Å)
Cite:To be Published
To be Published
1QLL
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BU of 1qll by Molmil
Piratoxin-II (Prtx-II) - a K49 PLA2 from Bothrops pirajai
Descriptor: N-TRIDECANOIC ACID, PHOSPHOLIPASE A2
Authors:Lee, W.-H, Polikarpov, I.
Deposit date:1999-09-01
Release date:2000-09-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Basis for Low Catalytic Activity in Lys49 Phospholipases A2-A Hypothesis: The Crystal Structure of Piratoxin II Complexed to Fatty Acid
Biochemistry, 40, 2001
3KGU
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BU of 3kgu by Molmil
Wild type human transthyretin (TTR) complexed with genistein (TTRwt:GEN) pH 7.5
Descriptor: GENISTEIN, Transthyretin
Authors:Trivella, D.B, Polikarpov, I.
Deposit date:2009-10-29
Release date:2010-03-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding.
J.Struct.Biol., 170, 2010
4CI5
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BU of 4ci5 by Molmil
Structural basis for GL479 a dual Peroxisome Proliferator-Activated Receptor gamma agonist
Descriptor: 2-methyl-2-[4-[2-[4-[(E)-phenyldiazenyl]phenoxy]ethyl]phenoxy]propanoic acid, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
Authors:Santos, J.C, Bernardes, A, Polikarpov, I.
Deposit date:2013-12-05
Release date:2014-12-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Different binding and recognition modes of GL479, a dual agonist of Peroxisome Proliferator-Activated Receptor alpha / gamma.
J. Struct. Biol., 191, 2015
4DES
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BU of 4des by Molmil
Crystal Structure of the Wild Type TTR Binding Chrysin (TTRwt:CHR)
Descriptor: Transthyretin, chrysin
Authors:Trivella, D.B.B, Polikarpov, I.
Deposit date:2012-01-21
Release date:2012-11-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis.
J.Struct.Biol., 180, 2012
4BCR
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BU of 4bcr by Molmil
Structure of PPARalpha in complex with WY14643
Descriptor: 1,2-ETHANEDIOL, 2-({4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]PYRIMIDIN-2-YL}SULFANYL)ACETIC ACID, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA
Authors:Bernardes, A, Muniz, J.R.C, Polikarpov, I.
Deposit date:2012-10-02
Release date:2013-05-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Molecular Mechanism of Peroxisome Proliferator-Activated Receptor Alpha Activation by Wy14643: A New Mode of Ligand Recognition and Receptor Stabilization
J.Mol.Biol., 425, 2013
4DET
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BU of 4det by Molmil
Crystal Structure of the Wild Type TTR Binding Kaempferol (TTRwt:KAE)
Descriptor: 3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE, Transthyretin
Authors:Trivella, D.B.B, Polikarpov, I.
Deposit date:2012-01-22
Release date:2012-11-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis.
J.Struct.Biol., 180, 2012
4DER
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BU of 4der by Molmil
Crystal Structure of the Wild Type TTR Binding Apigenin (TTRwt:API)
Descriptor: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, GLYCEROL, Transthyretin
Authors:Trivella, D.B.B, Polikarpov, I.
Deposit date:2012-01-21
Release date:2012-11-21
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis.
J.Struct.Biol., 180, 2012
4DEW
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BU of 4dew by Molmil
Crystal Structure of the Wild Type TTR Binding Luteolin (TTRwt:LUT)
Descriptor: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, Transthyretin
Authors:Trivella, D.B.B, Polikarpov, I.
Deposit date:2012-01-22
Release date:2012-11-21
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis.
J.Struct.Biol., 180, 2012
4EMA
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BU of 4ema by Molmil
Human peroxisome proliferator-activated receptor gamma in complex with rosiglitazone
Descriptor: 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), Peroxisome proliferator-activated receptor gamma
Authors:Liberato, M.V, Nascimento, A.S, Polikarpov, I.
Deposit date:2012-04-11
Release date:2013-03-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.545 Å)
Cite:Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) Gamma activators and pan-PPAR partial agonists
Plos One, 7, 2012
4EM9
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BU of 4em9 by Molmil
Human PPAR gamma in complex with nonanoic acids
Descriptor: 3,3',3''-phosphanetriyltripropanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor gamma, ...
Authors:Liberato, M.V, Nascimento, A.S, Polikarpov, I.
Deposit date:2012-04-11
Release date:2013-03-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) Gamma activators and pan-PPAR partial agonists
Plos One, 7, 2012
4CI4
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BU of 4ci4 by Molmil
Structural basis for GL479 a dual Peroxisome Proliferator-Activated Receptor alpha agonist
Descriptor: 2-methyl-2-[4-[2-[4-[(E)-phenyldiazenyl]phenoxy]ethyl]phenoxy]propanoic acid, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA
Authors:Santos, J.C, Bernardes, A, Polikarpov, I.
Deposit date:2013-12-05
Release date:2014-12-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:Different binding and recognition modes of GL479, a dual agonist of Peroxisome Proliferator-Activated Receptor alpha / gamma.
J. Struct. Biol., 191, 2015
4CVU
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BU of 4cvu by Molmil
Structure of Fungal beta-mannosidase from Glycoside Hydrolase Family 2 of Trichoderma harzianum
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BETA-MANNOSIDASE, CADMIUM ION, ...
Authors:Muniz, J.R.C, Aparicio, R, Santos, J.C, Nascimento, A.S, Golubev, A.M, Polikarpov, I.
Deposit date:2014-03-31
Release date:2014-07-09
Last modified:2023-07-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights into the structure and function of fungal beta-mannosidases from glycoside hydrolase family 2 based on multiple crystal structures of the Trichoderma harzianum enzyme.
FEBS J., 281, 2014

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