2GZH
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![BU of 2gzh by Molmil](/molmil-images/mine/2gzh) | |
5TXE
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![BU of 5txe by Molmil](/molmil-images/mine/5txe) | |
1OEU
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![BU of 1oeu by Molmil](/molmil-images/mine/1oeu) | Oxidation state of protein tyrosine phosphatase 1B | Descriptor: | MAGNESIUM ION, PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 | Authors: | van Montfort, R.L.M, Congreve, M, Tisi, D, Carr, R, Jhoti, H. | Deposit date: | 2003-03-31 | Release date: | 2003-06-12 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B. Nature, 423, 2003
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5TXC
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![BU of 5txc by Molmil](/molmil-images/mine/5txc) | AtxE2 Isopeptidase - APO | Descriptor: | AtxE2 | Authors: | Chekan, J.R, Nair, S.K. | Deposit date: | 2016-11-16 | Release date: | 2016-12-21 | Last modified: | 2017-01-04 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | Structure of the Lasso Peptide Isopeptidase Identifies a Topology for Processing Threaded Substrates. J. Am. Chem. Soc., 138, 2016
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1OEV
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![BU of 1oev by Molmil](/molmil-images/mine/1oev) | Oxidation state of protein tyrosine phosphatase 1B | Descriptor: | MAGNESIUM ION, PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 | Authors: | van Montfort, R.L.M, Congreve, M, Tisi, D, Carr, R, Jhoti, H. | Deposit date: | 2003-03-31 | Release date: | 2003-06-12 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B. Nature, 423, 2003
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1OES
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![BU of 1oes by Molmil](/molmil-images/mine/1oes) | Oxidation state of protein tyrosine phosphatase 1B | Descriptor: | MAGNESIUM ION, PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 | Authors: | van Montfort, R.L.M, Congreve, M, Tisi, D, Carr, R, Jhoti, H. | Deposit date: | 2003-03-31 | Release date: | 2003-06-12 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B. Nature, 423, 2003
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1OET
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![BU of 1oet by Molmil](/molmil-images/mine/1oet) | Oxidation state of protein tyrosine phosphatase 1B | Descriptor: | -TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1, MAGNESIUM ION | Authors: | van Montfort, R.L.M, Congreve, M, Tisi, D, Carr, R, Jhoti, H. | Deposit date: | 2003-03-31 | Release date: | 2003-06-12 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B. Nature, 423, 2003
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2M8F
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![BU of 2m8f by Molmil](/molmil-images/mine/2m8f) | Structure of lasso peptide astexin3 | Descriptor: | astexin3 | Authors: | Maksimov, M.O, Link, A. | Deposit date: | 2013-05-18 | Release date: | 2013-07-31 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Discovery and characterization of an isopeptidase that linearizes lasso peptides. J.Am.Chem.Soc., 135, 2013
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2N6V
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![BU of 2n6v by Molmil](/molmil-images/mine/2n6v) | Solution study of Astexin3 | Descriptor: | ASTEXIN3 | Authors: | Link, A, Maksimov, M.O. | Deposit date: | 2015-08-28 | Release date: | 2015-11-11 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Elucidating the Specificity Determinants of the AtxE2 Lasso Peptide Isopeptidase. J.Biol.Chem., 290, 2015
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2N6U
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![BU of 2n6u by Molmil](/molmil-images/mine/2n6u) | Solution study of Astexin2-dC4 | Descriptor: | Astexin2-dC4 | Authors: | Link, A, Maksimov, M.O. | Deposit date: | 2015-08-28 | Release date: | 2015-11-11 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Elucidating the Specificity Determinants of the AtxE2 Lasso Peptide Isopeptidase. J.Biol.Chem., 290, 2015
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1SUG
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![BU of 1sug by Molmil](/molmil-images/mine/1sug) | 1.95 A structure of apo protein tyrosine phosphatase 1B | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Protein-tyrosine phosphatase, ... | Authors: | Pedersen, A.K, Peters, G.H, Moller, K.B, Iversen, L.F, Kastrup, J.S. | Deposit date: | 2004-03-26 | Release date: | 2004-09-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Water-molecule network and active-site flexibility of apo protein tyrosine phosphatase 1B. Acta Crystallogr.,Sect.D, 60, 2004
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8UVO
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![BU of 8uvo by Molmil](/molmil-images/mine/8uvo) | Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC804515) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, N-[3-(2,5-difluoro-4-{[(4M)-5-(hexylsulfanyl)-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl]propanamide, Transitional endoplasmic reticulum ATPase | Authors: | Nandi, P, DeVore, K, Chiu, P.-L. | Deposit date: | 2023-11-03 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors. Commun Chem, 7, 2024
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8UVQ
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![BU of 8uvq by Molmil](/molmil-images/mine/8uvq) | Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC819701/down) | Descriptor: | 2-[(4P)-4-(4-{[(4P)-5-(cyclohexylsulfanyl)-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}-2,5-difluorophenyl)-2H-1,2,3-triazol-2-yl]-1-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethan-1-one, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Nandi, P, DeVore, K, Chiu, P.-L. | Deposit date: | 2023-11-03 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors. Commun Chem, 7, 2024
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8UV2
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![BU of 8uv2 by Molmil](/molmil-images/mine/8uv2) | Human p97/VCP structure with a triazole inhibitor (NSC799462/hexamer) | Descriptor: | 3-(2,6-difluoro-4-{[(4P)-5-{[(2S)-hexan-2-yl]sulfanyl}-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl (1-methylpiperidin-4-yl)carbamate, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Nandi, P, DeVore, K, Chiu, P.-L. | Deposit date: | 2023-11-02 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors. Commun Chem, 7, 2024
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8UVP
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![BU of 8uvp by Molmil](/molmil-images/mine/8uvp) | Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC819701/up) | Descriptor: | 2-[(4P)-4-(4-{[(4P)-5-(cyclohexylsulfanyl)-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}-2,5-difluorophenyl)-2H-1,2,3-triazol-2-yl]-1-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethan-1-one, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Nandi, P, DeVore, K, Chiu, P.-L. | Deposit date: | 2023-11-03 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors. Commun Chem, 7, 2024
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1BZC
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![BU of 1bzc by Molmil](/molmil-images/mine/1bzc) | HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI | Descriptor: | 4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) | Authors: | Groves, M.R, Yao, Z.J, Jr Burke, T.R, Barford, D. | Deposit date: | 1998-10-27 | Release date: | 1999-02-16 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry, 37, 1998
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1EEO
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![BU of 1eeo by Molmil](/molmil-images/mine/1eeo) | CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2 | Descriptor: | ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2 PEPTIDE, MAGNESIUM ION, PROTEIN TYROSINE PHOSPHATASE 1B | Authors: | Sarmiento, M, Puius, Y.A, Vetter, S.W, Lawrence, D.S, Almo, S.C, Zhang, Z.Y. | Deposit date: | 2000-02-01 | Release date: | 2001-02-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition. Biochemistry, 39, 2000
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1BZH
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![BU of 1bzh by Molmil](/molmil-images/mine/1bzh) | Cyclic peptide inhibitor of human PTP1B | Descriptor: | PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR), PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B) | Authors: | Groves, M.R, Yao, Z.J, Burke Jr, T.R, Barford, D. | Deposit date: | 1998-10-28 | Release date: | 1999-02-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry, 37, 1998
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1DJ8
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1EEN
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![BU of 1een by Molmil](/molmil-images/mine/1een) | CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-D-A-D-BPA-PTYR-L-I-P-Q-Q-G | Descriptor: | ACETIC ACID, ALA-ASP-PBF-PTR-LEU-ILE-PRO, MAGNESIUM ION, ... | Authors: | Puius, Y.A, Zhao, Y, Almo, S.C, Zhang, Z.Y. | Deposit date: | 2000-02-01 | Release date: | 2001-02-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition. Biochemistry, 39, 2000
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