6RH6
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![BU of 6rh6 by Molmil](/molmil-images/mine/6rh6) | Solution structure and 1H, 13C and 15N chemical shift assignments for the complex of NECAP1 PHear domain with phosphorylated AP2 mu2 148-163 | Descriptor: | AP-2 complex subunit mu, Adaptin ear-binding coat-associated protein 1 | Authors: | Owen, D.J, Neuhaus, D, Yang, J.-C, Herrmann, T. | Deposit date: | 2019-04-18 | Release date: | 2019-09-04 | Method: | SOLUTION NMR | Cite: | Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation. Dev.Cell, 50, 2019
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4JEH
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![BU of 4jeh by Molmil](/molmil-images/mine/4jeh) | Crystal Structure of Munc18a and Syntaxin1 lacking N-peptide complex | Descriptor: | Syntaxin-1A, Syntaxin-binding protein 1 | Authors: | Colbert, K.N, Hattendorf, D.A, Weiss, T.M, Burkhardt, P, Fasshauer, D, Weis, W.I. | Deposit date: | 2013-02-27 | Release date: | 2013-07-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation. Proc.Natl.Acad.Sci.USA, 110, 2013
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4JEU
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![BU of 4jeu by Molmil](/molmil-images/mine/4jeu) | Crystal Structure of Munc18a and Syntaxin1 with native N-terminus complex | Descriptor: | Syntaxin-1A, Syntaxin-binding protein 1 | Authors: | Colbert, K.N, Hattendorf, D.A, Weiss, T.M, Burkhardt, P, Fasshauer, D, Weis, W.I. | Deposit date: | 2013-02-27 | Release date: | 2013-07-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation. Proc.Natl.Acad.Sci.USA, 110, 2013
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2JMX
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![BU of 2jmx by Molmil](/molmil-images/mine/2jmx) | OSCP-NT (1-120) in complex with N-terminal (1-25) alpha subunit from F1-ATPase | Descriptor: | ATP synthase O subunit, mitochondrial, ATP synthase subunit alpha heart isoform | Authors: | Carbajo, R.J, Neuhaus, D, Kellas, F.A, Yang, J, Runswick, M.J, Montgomery, M.G, Walker, J.E. | Deposit date: | 2006-12-12 | Release date: | 2007-04-24 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | How the N-terminal Domain of the OSCP Subunit of Bovine F(1)F(o)-ATP Synthase Interacts with the N-terminal Region of an Alpha Subunit J.Mol.Biol., 368, 2007
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2JP7
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![BU of 2jp7 by Molmil](/molmil-images/mine/2jp7) | NMR structure of the Mex67 UBA domain | Descriptor: | mRNA export factor MEX67 | Authors: | Hobeika, M, Brockmann, C, Iglesias, N, Gwizdek, C, Neuhaus, D, Stutz, F, Stewart, M, Divita, G, Dargemont, C. | Deposit date: | 2007-04-26 | Release date: | 2007-07-10 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | Coordination of Hpr1 and ubiquitin binding by the UBA domain of the mRNA export factor Mex67 Mol.Cell.Biol., 18, 2007
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2JPS
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![BU of 2jps by Molmil](/molmil-images/mine/2jps) | NAB2 N-terminal domain | Descriptor: | Nuclear polyadenylated RNA-binding protein NAB2 | Authors: | Grant, R, Marshall, N.J, Yang, J, Fasken, M, Kelly, S, Harreman, M.T, Neuhaus, D, Corbett, A.H, Stewart, M. | Deposit date: | 2007-05-23 | Release date: | 2008-03-18 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | Structure of the N-terminal Mlp1-binding domain of the Saccharomyces cerevisiae mRNA-binding protein, Nab2 J.Mol.Biol., 376, 2008
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2KHH
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![BU of 2khh by Molmil](/molmil-images/mine/2khh) | Structural requirements for the UBA domain of the mRNA export factor Mex67 to bind its specific targets, the transcription elongation Tho complex component Hpr1 and nucleoporin FxFG repeats | Descriptor: | FxFG, mRNA export factor MEX67 | Authors: | Hobeika, M, Brockmann, C, Gruessing, F, Neuhaus, D, Divita, G, Stewart, M, Dargemont, C. | Deposit date: | 2009-04-06 | Release date: | 2009-05-12 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural requirements for the ubiquitin-associated domain of the mRNA export factor Mex67 to bind its specific targets, the transcription elongation THO complex component Hpr1 and nucleoporin FXFG repeats J.Biol.Chem., 284, 2009
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2K0A
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![BU of 2k0a by Molmil](/molmil-images/mine/2k0a) | 1H, 15N and 13C chemical shift assignments for Rds3 protein | Descriptor: | Pre-mRNA-splicing factor RDS3, ZINC ION | Authors: | Loening, N, van Roon, A, Yang, J, Nagai, K, Neuhaus, D. | Deposit date: | 2008-01-31 | Release date: | 2008-07-22 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the U2 snRNP protein Rds3p reveals a knotted zinc-finger motif. Proc.Natl.Acad.Sci.Usa, 105, 2008
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2JWQ
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![BU of 2jwq by Molmil](/molmil-images/mine/2jwq) | G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study | Descriptor: | DNA (5'-D(*DTP*DTP*DAP*DGP*DGP*DGP*DT)-3'), N,N'-(dibenzo[b,j][1,7]phenanthroline-2,10-diyldimethanediyl)dipropan-1-amine | Authors: | Hounsou, C, Guittat, L, Monchaud, D, Jourdan, M, Saettel, N, Mergny, J.L, Teulade-Fichou, M. | Deposit date: | 2007-10-23 | Release date: | 2008-03-25 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study ChemMedChem, 2, 2007
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2L5G
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![BU of 2l5g by Molmil](/molmil-images/mine/2l5g) | Co-ordinates and 1H, 13C and 15N chemical shift assignments for the complex of GPS2 53-90 and SMRT 167-207 | Descriptor: | G protein pathway suppressor 2, Putative uncharacterized protein NCOR2 | Authors: | Oberoi, J, Yang, J, Neuhaus, D, Schwabe, J.W.R. | Deposit date: | 2010-11-01 | Release date: | 2011-02-02 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery. Nat.Struct.Mol.Biol., 18, 2011
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2LHN
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![BU of 2lhn by Molmil](/molmil-images/mine/2lhn) | RNA-binding zinc finger protein | Descriptor: | Nuclear polyadenylated RNA-binding protein NAB2, ZINC ION | Authors: | Brockmann, C, Neuhaus, D, Stewart, M. | Deposit date: | 2011-08-12 | Release date: | 2012-06-27 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural Basis for Polyadenosine-RNA Binding by Nab2 Zn Fingers and Its Function in mRNA Nuclear Export. Structure, 20, 2012
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8AUT
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![BU of 8aut by Molmil](/molmil-images/mine/8aut) | WelO5* L221A bound to Zn(II), Cl, 2-oxoglutarate, and 12-epi-hapalindole C | Descriptor: | 2-OXOGLUTARIC ACID, 3-[(1~{S},2~{R},3~{S},6~{S})-3-ethenyl-2-isocyano-3-methyl-6-prop-1-en-2-yl-cyclohexyl]-1~{H}-indole, CHLORIDE ION, ... | Authors: | Buller, R, Hueppi, S, Voss, M, Schaub, D. | Deposit date: | 2022-08-25 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.685 Å) | Cite: | Enzyme engineering enables inversion of substrate stereopreference of the halogenase WelO5* Chemcatchem, 2022
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5TXS
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![BU of 5txs by Molmil](/molmil-images/mine/5txs) | Crystal structure of an anaplastic lymphoma kinase-derived neuroblastoma tumor antigen bound to the Human Major Histocompatibility Complex Class I molecule HLA-B*1501 | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-15 alpha chain, ... | Authors: | Toor, J, Rao, A.A, Salama, S, Tripathi, S, Haussler, D, Sgourakis, N.G. | Deposit date: | 2016-11-17 | Release date: | 2017-11-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.697 Å) | Cite: | A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations. Front Immunol, 9, 2018
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6CSJ
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![BU of 6csj by Molmil](/molmil-images/mine/6csj) | |
5VSB
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![BU of 5vsb by Molmil](/molmil-images/mine/5vsb) | Structure of DUB complex | Descriptor: | 7-chloro-3-{[4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl]methyl}quinazolin-4(3H)-one, Ubiquitin carboxyl-terminal hydrolase 7 | Authors: | Seo, H.-S, Dhe-Paganon, S. | Deposit date: | 2017-05-11 | Release date: | 2017-12-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7. Cell Chem Biol, 24, 2017
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5VS6
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![BU of 5vs6 by Molmil](/molmil-images/mine/5vs6) | Structure of DUB complex | Descriptor: | ACETATE ION, GLYCEROL, N-[3-({4-hydroxy-1-[(3R)-3-phenylbutanoyl]piperidin-4-yl}methyl)-4-oxo-3,4-dihydroquinazolin-7-yl]-3-(4-methylpiperazin-1-yl)propanamide, ... | Authors: | Seo, H.-S, Dhe-Paganon, S. | Deposit date: | 2017-05-11 | Release date: | 2017-12-20 | Last modified: | 2018-01-03 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7. Cell Chem Biol, 24, 2017
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5VSK
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![BU of 5vsk by Molmil](/molmil-images/mine/5vsk) | Structure of DUB complex | Descriptor: | 7-chloro-3-({4-hydroxy-1-[(3S)-3-phenylbutanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one, Ubiquitin carboxyl-terminal hydrolase 7, ZINC ION | Authors: | Seo, H.-Y, Dhe-Paganon, S. | Deposit date: | 2017-05-11 | Release date: | 2017-12-20 | Last modified: | 2018-01-03 | Method: | X-RAY DIFFRACTION (3.33 Å) | Cite: | Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7. Cell Chem Biol, 24, 2017
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8BUM
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![BU of 8bum by Molmil](/molmil-images/mine/8bum) | Structure of DDB1 bound to DS15-engaged CDK12-cyclin K | Descriptor: | (2R)-2-[[6-(5-naphthalen-1-ylpentylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | Authors: | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | Deposit date: | 2022-11-30 | Release date: | 2023-09-20 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (3.36 Å) | Cite: | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BU7
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![BU of 8bu7 by Molmil](/molmil-images/mine/8bu7) | Structure of DDB1 bound to 21195-engaged CDK12-cyclin K | Descriptor: | 1,2-ETHANEDIOL, 1-[2,6-bis(chloranyl)phenyl]-6-[[4-(2-hydroxyethyloxy)phenyl]methyl]-3-propan-2-yl-5H-pyrazolo[3,4-d]pyrimidin-4-one, Cyclin-K, ... | Authors: | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | Deposit date: | 2022-11-30 | Release date: | 2023-09-13 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (3.245 Å) | Cite: | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUN
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![BU of 8bun by Molmil](/molmil-images/mine/8bun) | Structure of DDB1 bound to DS16-engaged CDK12-cyclin K | Descriptor: | (2~{R})-2-[[6-[(4-phenylphenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | Authors: | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | Deposit date: | 2022-11-30 | Release date: | 2023-09-13 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (3.08 Å) | Cite: | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BU2
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![BU of 8bu2 by Molmil](/molmil-images/mine/8bu2) | Structure of DDB1 bound to DS18-engaged CDK12-cyclin K | Descriptor: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | Authors: | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | Deposit date: | 2022-11-30 | Release date: | 2023-09-13 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (3.13 Å) | Cite: | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUA
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![BU of 8bua by Molmil](/molmil-images/mine/8bua) | Structure of DDB1 bound to 919278-engaged CDK12-cyclin K | Descriptor: | (2~{R})-~{N}-(1~{H}-benzimidazol-2-yl)-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)propanamide, CITRIC ACID, Cyclin-K, ... | Authors: | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | Deposit date: | 2022-11-30 | Release date: | 2023-09-13 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (3.193 Å) | Cite: | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUI
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![BU of 8bui by Molmil](/molmil-images/mine/8bui) | Structure of DDB1 bound to DRF-053-engaged CDK12-cyclin K | Descriptor: | (2~{R})-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)amino]purin-2-yl]amino]butan-1-ol, 1,2-ETHANEDIOL, Cyclin-K, ... | Authors: | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | Deposit date: | 2022-11-30 | Release date: | 2023-09-13 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUR
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![BU of 8bur by Molmil](/molmil-images/mine/8bur) | Structure of DDB1 bound to DS50-engaged CDK12-cyclin K | Descriptor: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | Authors: | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | Deposit date: | 2022-11-30 | Release date: | 2023-09-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.64 Å) | Cite: | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUF
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![BU of 8buf by Molmil](/molmil-images/mine/8buf) | Structure of DDB1 bound to Z12-engaged CDK12-cyclin K | Descriptor: | 2-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-ylmethyl)-6,7-dimethoxy-3~{H}-quinazolin-4-one, Cyclin-K, Cyclin-dependent kinase 12, ... | Authors: | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | Deposit date: | 2022-11-30 | Release date: | 2023-09-13 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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