4GWY
 
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4GWS
 | | Crystal Structure of AMP complexes of Porcine Liver Fructose-1,6-bisphosphatase with Filled Central Cavity | | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, ... | | Authors: | Gao, Y, Honzatko, R.B. | | Deposit date: | 2012-09-03 | | Release date: | 2013-09-04 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Hydrophobic Central Cavity in Fructose-1,6-bisphosphatase is Essential for the Synergism in AMP/Fructose 2,6-bisphosphate Inhibition
To be Published
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4GWZ
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5L9X
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4H45
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4H46
 | | Crystal Structure of AMP complexes of NEM modified Porcine Liver Fructose-1,6-bisphosphatase | | Descriptor: | 1-ETHYL-PYRROLIDINE-2,5-DIONE, 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, ... | | Authors: | Gao, Y, Honzatko, R.B. | | Deposit date: | 2012-09-16 | | Release date: | 2013-09-18 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Fluorescent 2',3'-O-(2,4,6-trinitrophenyl) (TNP)-AMP Is an Active Site Inhibitor for Porcine Liver Fructose-1,6-bisphosphatase Rather Than Allosteric Inhibitor
To be Published
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7Z1I
 | | Plant myrosinase TGG1 from Arabidopsis thaliana | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Gao, Y, Farmer, E, Jimenez-Sandoval, P, Santiago, J. | | Deposit date: | 2022-02-24 | | Release date: | 2023-03-08 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.09 Å) | | Cite: | Plant myrosinase TGG1 from Arabidopsis thaliana
To Be Published
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8HR7
 | | Structure of RdrA-RdrB complex | | Descriptor: | Adenosine deaminase, Archaeal ATPase | | Authors: | Gao, Y. | | Deposit date: | 2022-12-15 | | Release date: | 2023-02-01 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.96 Å) | | Cite: | Molecular basis of RADAR anti-phage supramolecular assemblies.
Cell, 186, 2023
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8HRB
 | | Structure of tetradecameric RdrA ring in RNA-loading state | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Archaeal ATPase, RNA (5'-R(*GP*UP*CP*CP*AP*GP*CP*GP*UP*CP*AP*UP*CP*GP*CP*UP*GP*GP*AP*C)-3') | | Authors: | Gao, Y. | | Deposit date: | 2022-12-15 | | Release date: | 2023-02-01 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.78 Å) | | Cite: | Molecular basis of RADAR anti-phage supramolecular assemblies.
Cell, 186, 2023
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8HRC
 | | Structure of dodecameric RdrB cage | | Descriptor: | Adenosine deaminase | | Authors: | Gao, Y. | | Deposit date: | 2022-12-15 | | Release date: | 2023-02-01 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (2.58 Å) | | Cite: | Molecular basis of RADAR anti-phage supramolecular assemblies.
Cell, 186, 2023
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8HR8
 | | Structure of heptameric RdrA ring | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Archaeal ATPase | | Authors: | Gao, Y. | | Deposit date: | 2022-12-15 | | Release date: | 2023-02-01 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Molecular basis of RADAR anti-phage supramolecular assemblies.
Cell, 186, 2023
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8HR9
 | | Structure of tetradecameric RdrA ring | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Archaeal ATPase | | Authors: | Gao, Y. | | Deposit date: | 2022-12-15 | | Release date: | 2023-02-01 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.03 Å) | | Cite: | Molecular basis of RADAR anti-phage supramolecular assemblies.
Cell, 186, 2023
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8HRA
 | | Structure of heptameric RdrA ring in RNA-loading state | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Archaeal ATPase, RNA (5'-R(P*GP*UP*CP*CP*AP*GP*CP*GP*UP*CP*AP*UP*CP*GP*CP*UP*GP*GP*AP*C)-3') | | Authors: | Gao, Y. | | Deposit date: | 2022-12-15 | | Release date: | 2023-02-01 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.76 Å) | | Cite: | Molecular basis of RADAR anti-phage supramolecular assemblies.
Cell, 186, 2023
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5WRW
 | | Structure of human apo-SRP72 | | Descriptor: | SULFATE ION, Signal recognition particle subunit SRP72 | | Authors: | Gao, Y, Chen, Z. | | Deposit date: | 2016-12-04 | | Release date: | 2017-06-21 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.91 Å) | | Cite: | Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation
J Mol Cell Biol, 9, 2017
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8FTI
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8E2L
 | | Structure of Lates calcarifer Twinkle helicase with ATP and DNA | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, ... | | Authors: | Gao, Y, Li, Z. | | Deposit date: | 2022-08-15 | | Release date: | 2022-11-02 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Structural and dynamic basis of DNA capture and translocation by mitochondrial Twinkle helicase.
Nucleic Acids Res., 50, 2022
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7BTK
 | | E.coli beta-galactosidase (E537Q) in complex with fluorescent probe KSA01 | | Descriptor: | 4-[[2-[(E)-2-[4-[(2S,3R,4S,5R,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxyphenyl]ethenyl]-3,3-dimethyl-2H-indol-1-yl]methyl]benzoic acid, Beta-galactosidase, DIMETHYL SULFOXIDE, ... | | Authors: | Chen, X, Hu, Y.L, Liu, Q.M, Gao, Y, Yuan, R, Guo, Y. | | Deposit date: | 2020-04-01 | | Release date: | 2021-03-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Two-Dimensional Design Strategy to Construct Smart Fluorescent Probes for the Precise Tracking of Senescence.
Angew.Chem.Int.Ed.Engl., 60, 2021
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7BRS
 | | E.coli beta-galactosidase (E537Q) in complex with fluorescent probe KSA02 | | Descriptor: | 8-[2-[(E)-2-[4-[(2S,3R,4S,5R,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxyphenyl]ethenyl]-3,3-dimethyl-indol-1-ium-1-yl]octanoic acid, Beta-galactosidase, DIMETHYL SULFOXIDE, ... | | Authors: | Chen, X, Hu, Y.L, Gao, Y, Yuan, R, Guo, Y. | | Deposit date: | 2020-03-30 | | Release date: | 2021-03-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.67 Å) | | Cite: | Two-Dimensional Design Strategy to Construct Smart Fluorescent Probes for the Precise Tracking of Senescence.
Angew.Chem.Int.Ed.Engl., 60, 2021
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6LUM
 | | Structure of Mycobacterium smegmatis succinate dehydrogenase 2 | | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL, 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, ... | | Authors: | Gao, Y, Gong, H, Zhou, X, Xiao, Y, Wang, W, Ji, W, Wang, Q, Rao, Z. | | Deposit date: | 2020-01-29 | | Release date: | 2020-05-27 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF.
Nat Commun, 11, 2020
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8J74
 | | Human high-affinity choline transporter CHT1 in the HC-3-bound outward-facing open conformation, dimeric state | | Descriptor: | (2S,2'S)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium), CHOLESTEROL HEMISUCCINATE, HEXADECANE, ... | | Authors: | Gao, Y, Qiu, Y, Zhao, Y. | | Deposit date: | 2023-04-27 | | Release date: | 2024-04-03 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Transport mechanism of presynaptic high-affinity choline uptake by CHT1.
Nat.Struct.Mol.Biol., 31, 2024
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8J75
 | | Human high-affinity choline transporter CHT1 in the HC-3-bound outward-facing open conformation, monomeric state | | Descriptor: | (2S,2'S)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium), High affinity choline transporter 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Gao, Y, Qiu, Y, Zhao, Y. | | Deposit date: | 2023-04-27 | | Release date: | 2024-04-10 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Transport mechanism of presynaptic high-affinity choline uptake by CHT1.
Nat.Struct.Mol.Biol., 31, 2024
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8J76
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8J77
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7YDS
 | | The structure of the bispecific antibody targeted PD-L1 and 4-1BB | | Descriptor: | Anti-PDL1-VH-CH1, Anti-PDL1-VL-CL, Programmed cell death 1 ligand 1 | | Authors: | Gao, Y, Zhu, M, Liu, W.T, Cheng, L.S, Zhu, Z.L, Niu, L.W. | | Deposit date: | 2022-07-04 | | Release date: | 2023-07-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A bispecific antibody targeted PD-L1 and 4-1BB induces a potent antitumor immune activity in colorectal cancer without systemic toxicity
To Be Published
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6IIC
 | | CryoEM structure of Mud Crab Dicistrovirus | | Descriptor: | VP1 of Mud crab dicistrovirus, VP2 of Mud crab dicistrovirus, VP3 of Mud crab dicistrovirus, ... | | Authors: | Zhang, Q, Gao, Y. | | Deposit date: | 2018-10-04 | | Release date: | 2019-01-16 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-electron Microscopy Structures of Novel Viruses from Mud CrabScylla paramamosainwith Multiple Infections.
J. Virol., 93, 2019
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