4GZR
 
 | | Crystal structure of the Mycobacterium tuberculosis H37Rv EsxOP (Rv2346c-Rv2347c) complex in space group C2221 | | Descriptor: | ESAT-6-like protein 6, ESAT-6-like protein 7, SULFATE ION | | Authors: | Arbing, M.A, Chan, S, He, Q, Harris, L, Zhou, T.T, Kuo, E, Ahn, C.J, Eisenberg, D, TB Structural Genomics Consortium (TBSGC), Integrated Center for Structure and Function Innovation (ISFI) | | Deposit date: | 2012-09-06 | | Release date: | 2012-09-26 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.553 Å) | | Cite: | Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions.
Plos One, 8, 2013
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3H87
 | | Rv0301 Rv0300 Toxin Antitoxin Complex from Mycobacterium tuberculosis | | Descriptor: | BETA-MERCAPTOETHANOL, GLYCEROL, IMIDAZOLE, ... | | Authors: | Min, A, Sawaya, M.R, Cascio, D, Eisenberg, D, Integrated Center for Structure and Function Innovation (ISFI) | | Deposit date: | 2009-04-28 | | Release date: | 2009-05-05 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg(2+) ion in the active site and a putative RNA-binding site.
Protein Sci., 21, 2012
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1K26
 | | Structure of a Nudix Protein from Pyrobaculum aerophilum Solved by the Single Wavelength Anomolous Scattering Method | | Descriptor: | ACETIC ACID, GLYCEROL, IRIDIUM (III) ION, ... | | Authors: | Wang, S, Mura, C, Sawaya, M.R, Cascio, D, Eisenberg, D. | | Deposit date: | 2001-09-26 | | Release date: | 2002-04-03 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure of a Nudix protein from Pyrobaculum aerophilum reveals a dimer with two intersubunit beta-sheets.
Acta Crystallogr.,Sect.D, 58, 2002
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1K2E
 | | crystal structure of a nudix protein from Pyrobaculum aerophilum | | Descriptor: | ACETIC ACID, GLYCEROL, NICKEL (II) ION, ... | | Authors: | Wang, S, Mura, C, Sawaya, M.R, Cascio, D, Eisenberg, D. | | Deposit date: | 2001-09-26 | | Release date: | 2002-04-03 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure of a Nudix protein from Pyrobaculum aerophilum reveals a dimer with two intersubunit beta-sheets.
Acta Crystallogr.,Sect.D, 58, 2002
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3FOD
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4E0K
 | | Crystal Structure of the amyloid-fibril forming peptide KDWSFY derived from human Beta 2 Microglobulin (58-63) | | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Amyloidogenic peptide segment KDWSFY, SODIUM ION | | Authors: | Zhao, M, Liu, C, Sawaya, M.R, Eisenberg, D. | | Deposit date: | 2012-03-04 | | Release date: | 2012-12-19 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (0.97 Å) | | Cite: | Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates.
Proc.Natl.Acad.Sci.USA, 109, 2012
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3FTL
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5E5V
 | | Structure of amyloid forming peptide NFGAILS (residues 22-28) from Islet Amyloid Polypeptide | | Descriptor: | NFGAILS (22-28) from islet amyloid polypeptide, synthesized | | Authors: | Soriaga, A.B, Macdonald, R, Sawaya, M.R, Sangwan, S, Eisenberg, D. | | Deposit date: | 2015-10-09 | | Release date: | 2015-12-16 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.24 Å) | | Cite: | Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets.
J.Phys.Chem.B, 120, 2016
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5E5Z
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3FTR
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3FR1
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3FTH
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5E61
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5E5X
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3MML
 | | Allophanate Hydrolase Complex from Mycobacterium smegmatis, Msmeg0435-Msmeg0436 | | Descriptor: | Allophanate hydrolase subunit 1, Allophanate hydrolase subunit 2, CHLORIDE ION | | Authors: | Kaufmann, M, Chernishof, I, Shin, A, Germano, D, Sawaya, M.R, Waldo, G.S, Arbing, M.A, Perry, J, Eisenberg, D, Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2010-04-20 | | Release date: | 2010-04-28 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of Allphanate Hydrolase Complex from M. smegmatis, Msmeg0435-Msmeg0436
To be Published
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5DBN
 | | Crystal structure of AtoDA complex | | Descriptor: | Acetate CoA-transferase subunit alpha, Acetate CoA-transferase subunit beta, CHLORIDE ION, ... | | Authors: | Arbing, M.A, Koo, C.W, Shin, A, Medrano-Soto, A, Eisenberg, D. | | Deposit date: | 2015-08-21 | | Release date: | 2016-08-24 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.549 Å) | | Cite: | Crystal structure of AtoDA complex
To Be Published
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5DB5
 | | Crystal structure of PLP-bound E. coli SufS (cysteine persulfide intermediate) in space group P21 | | Descriptor: | 1,2-ETHANEDIOL, CITRIC ACID, CYSTEINE, ... | | Authors: | Arbing, M.A, Shin, A, Koo, C.W, Medrano-Soto, A, Eisenberg, D. | | Deposit date: | 2015-08-20 | | Release date: | 2016-08-24 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Crystal structure of PLP-bound E. coli SufS (cysteine persulfide intermediate) in space group P21
To Be Published
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2QZV
 | | Draft Crystal Structure of the Vault Shell at 9 Angstroms Resolution | | Descriptor: | Major vault protein | | Authors: | Anderson, D.H, Kickhoefer, V.A, Sievers, S.A, Rome, L.H, Eisenberg, D. | | Deposit date: | 2007-08-17 | | Release date: | 2007-12-04 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (9 Å) | | Cite: | Draft crystal structure of the vault shell at 9-A resolution.
Plos Biol., 5, 2007
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3FTK
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3FVA
 | | NNQNTF segment from elk prion | | Descriptor: | Major prion protein | | Authors: | Apostol, M.I, Eisenberg, D. | | Deposit date: | 2009-01-15 | | Release date: | 2009-06-30 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.458 Å) | | Cite: | Molecular mechanisms for protein-encoded inheritance.
Nat.Struct.Mol.Biol., 16, 2009
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1MDT
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3T4G
 | | AIIGLMV segment from Alzheimer's Amyloid-Beta displayed on 54-membered macrocycle scaffold | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclic pseudo-peptide (ORN)AIIGLMV(ORN)KF(HAO)(4BF)K | | Authors: | Zhao, M, Liu, C, Cheng, P.N, Eisenberg, D, Nowick, J.S. | | Deposit date: | 2011-07-26 | | Release date: | 2012-10-31 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Amyloid beta-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity.
Nat Chem, 4, 2012
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4NP8
 | | Structure of an amyloid forming peptide VQIVYK from the second repeat region of tau (alternate polymorph) | | Descriptor: | Microtubule-associated protein tau | | Authors: | Landau, M, Eisenberg, D, Sawaya, M.R, Dannenberg, J, Kobko, N. | | Deposit date: | 2013-11-20 | | Release date: | 2013-12-18 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Molecular mechanisms for protein-encoded inheritance.
Nat.Struct.Mol.Biol., 16, 2009
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1Z6K
 | | Citrate lyase beta subunit complexed with oxaloacetate and magnesium from M. tuberculosis | | Descriptor: | Citrate Lyase beta subunit, MAGNESIUM ION, OXALOACETATE ION | | Authors: | Goulding, C.W, Bowers, P.M, Segelke, B, Lekin, T, Kim, C.Y, Terwilliger, T.C, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2005-03-22 | | Release date: | 2005-05-03 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The structure and computational analysis of Mycobacterium tuberculosis protein CitE suggest a novel enzymatic function.
J.Mol.Biol., 365, 2007
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4E0L
 | | FYLLYYT segment from human Beta 2 Microglobulin (62-68) displayed on 54-membered macrocycle scaffold | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclic pseudo-peptide FYLLYYT(ORN)KN(HAO)SA(ORN) | | Authors: | Zhao, M, Liu, C, Michael, S.R, Eisenberg, D. | | Deposit date: | 2012-03-04 | | Release date: | 2012-12-19 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates.
Proc.Natl.Acad.Sci.USA, 109, 2012
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