3NHD

GYVLGS segment 127-132 from human prion with V129

Summary for 3NHD

Entry DOI	10.2210/pdb3nhd/pdb
Related	3NHC
Descriptor	Major prion protein, ACETIC ACID (3 entities in total)
Functional Keywords	amyloid-like protofibril, protein fibril
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Lipid-anchor, GPI-anchor. Isoform 2: Cytoplasm: P04156
Total number of polymer chains	2
Total formula weight	1309.42
Authors	Apostol, M.I.,Eisenberg, D. (deposition date: 2010-06-14, release date: 2010-08-04, Last modification date: 2022-12-21)
Primary citation	Apostol, M.I.,Sawaya, M.R.,Cascio, D.,Eisenberg, D. Crystallographic studies of prion protein (PrP) segments suggest how structural changes encoded by polymorphism at residue 129 modulate susceptibility to human prion disease. J.Biol.Chem., 285:29671-29675, 2010 Cited by PubMed: 20685658 DOI: 10.1074/jbc.C110.158303 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation