8HMD
| base module state 2 of Tetrahymena IFT-A | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 43 homolog, Tetratricopeptide repeat protein, ... | Authors: | Ma, Y, Wu, J, Lei, M. | Deposit date: | 2022-12-03 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train. Nat Commun, 14, 2023
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8HME
| head module state 1 of Tetrahymena IFT-A | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transporter, WD40 repeat protein, ... | Authors: | Ma, Y, Wu, J, Lei, M. | Deposit date: | 2022-12-03 | Release date: | 2023-06-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train. Nat Commun, 14, 2023
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8HMC
| base module state 1 of Tetrahymena IFT-A | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 43 homolog, Tetratricopeptide repeat protein, ... | Authors: | Ma, Y, Wu, J, Lei, M. | Deposit date: | 2022-12-03 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train. Nat Commun, 14, 2023
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5Y58
| Crystal structure of Ku70/80 and TLC1 | Descriptor: | ATP-dependent DNA helicase II subunit 1, ATP-dependent DNA helicase II subunit 2, TLC1 | Authors: | Chen, H, Xue, J, Wu, J, Lei, M. | Deposit date: | 2017-08-08 | Release date: | 2017-12-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Insights into Yeast Telomerase Recruitment to Telomeres Cell, 172, 2018
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8HPP
| Crystal structure of human INTS3 with SAGE1 | Descriptor: | Integrator complex subunit 3, Sarcoma antigen 1 | Authors: | Deng, W, Wu, J, Lei, M. | Deposit date: | 2022-12-12 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Cancer-testis antigen SAGE1 is a pan-cancer master regulator of RNA polymerase II To Be Published
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3KF6
| Crystal structure of S. pombe Stn1-ten1 complex | Descriptor: | Protein stn1, Protein ten1 | Authors: | Sun, J, Yu, E.Y, Yang, Y.T, Confer, L.A, Sun, S.H, Wan, K, Lue, N.F, Lei, M. | Deposit date: | 2009-10-27 | Release date: | 2009-12-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev., 23, 2009
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3TOJ
| Structure of the SPRY domain of human Ash2L | Descriptor: | Set1/Ash2 histone methyltransferase complex subunit ASH2 | Authors: | Chen, Y, Cao, F, Wan, B, Dou, Y, Lei, M. | Deposit date: | 2011-09-05 | Release date: | 2012-01-25 | Last modified: | 2017-08-23 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30. Cell Res., 22, 2012
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8J0N
| cryo-EM structure of human EMC | Descriptor: | ER membrane protein complex subunit 1, ER membrane protein complex subunit 10, ER membrane protein complex subunit 2, ... | Authors: | Li, M, Zhang, C, Wu, J, Lei, M. | Deposit date: | 2023-04-11 | Release date: | 2024-04-03 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structural insights into human EMC and its interaction with VDAC. Aging (Albany NY), 16, 2024
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8J0O
| cryo-EM structure of human EMC and VDAC | Descriptor: | ER membrane protein complex subunit 1, ER membrane protein complex subunit 10, ER membrane protein complex subunit 2, ... | Authors: | Li, M, Zhang, C, Wu, J, Lei, M. | Deposit date: | 2023-04-11 | Release date: | 2024-04-03 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Structural insights into human EMC and its interaction with VDAC. Aging (Albany NY), 16, 2024
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3L82
| X-ray Crystal structure of TRF1 and Fbx4 complex | Descriptor: | F-box only protein 4, Telomeric repeat-binding factor 1 | Authors: | Zeng, Z.X, Wang, W, Yang, Y.T, Chen, Y, Yang, X.M, Diehl, J.A, Liu, X.D, Lei, M. | Deposit date: | 2009-12-29 | Release date: | 2010-03-09 | Last modified: | 2013-09-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis of Selective Ubiquitination of TRF1 by SCF(Fbx4) Dev.Cell, 18, 2010
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3K6G
| Crystal structure of Rap1 and TRF2 complex | Descriptor: | Telomeric repeat-binding factor 2, Telomeric repeat-binding factor 2-interacting protein 1 | Authors: | Chen, Y, Rai, R, Yang, Y.T, Zheng, H, Chang, S, Lei, M. | Deposit date: | 2009-10-08 | Release date: | 2010-10-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat.Struct.Mol.Biol., 18, 2011
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3U85
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3KEY
| Crystal structure of S. cerevisiae Stn1 C-terminal | Descriptor: | Protein STN1 | Authors: | Sun, J, Yu, E.Y, Yang, Y.T, Confer, L.A, Sun, S.H, Wan, K, Lue, N.F, Lei, M. | Deposit date: | 2009-10-26 | Release date: | 2009-12-22 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev., 23, 2009
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3KF8
| Crystal structure of C. tropicalis Stn1-ten1 complex | Descriptor: | Protein stn1, Protein ten1 | Authors: | Sun, J, Yu, E.Y, Yang, Y.T, Confer, L.A, Sun, S.H, Wan, K, Lue, N.F, Lei, M. | Deposit date: | 2009-10-27 | Release date: | 2009-12-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev., 23, 2009
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7LH9
| Crystal structure of BRPF2 PWWP domain in complex with DNA | Descriptor: | Bromodomain-containing protein 1, DNA | Authors: | Zhang, M, Lei, M, Qin, S, Dong, A, Yang, A, Li, Y, Loppnau, P, Hughes, T.R, Arrowsmith, C.H, Edwards, A.M, Min, J, Liu, J, Structural Genomics Consortium (SGC) | Deposit date: | 2021-01-21 | Release date: | 2021-02-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains. Biochim Biophys Acta Gene Regul Mech, 1864, 2021
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3U86
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3U4V
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3U4Z
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3U88
| Crystal structure of human menin in complex with MLL1 and LEDGF | Descriptor: | (4beta,8alpha,9R)-6'-methoxy-10,11-dihydrocinchonan-9-ol, CHOLIC ACID, GLYOXYLIC ACID, ... | Authors: | Huang, J, Wan, B, Lei, M. | Deposit date: | 2011-10-16 | Release date: | 2012-02-15 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature, 482, 2012
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3U58
| Crystal Structure of the Tetrahymena telomerase processivity factor Teb1 AB | Descriptor: | DNA (5'-D(*GP*GP*GP*T)-3'), Tetrahymena Teb1 AB | Authors: | Zeng, Z, Huang, J, Yang, Y, Lei, M. | Deposit date: | 2011-10-11 | Release date: | 2011-12-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.613 Å) | Cite: | Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA. Proc.Natl.Acad.Sci.USA, 108, 2011
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3U50
| Crystal Structure of the Tetrahymena telomerase processivity factor Teb1 OB-C | Descriptor: | Telomerase-associated protein 82, ZINC ION | Authors: | Zeng, Z, Huang, J, Yang, Y, Lei, M. | Deposit date: | 2011-10-10 | Release date: | 2011-12-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA. Proc.Natl.Acad.Sci.USA, 108, 2011
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3U84
| Crystal Structure of Human Menin | Descriptor: | Menin | Authors: | Huang, J, Wan, B, Lei, M. | Deposit date: | 2011-10-15 | Release date: | 2012-02-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature, 482, 2012
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7BU5
| Crystal Structure of Human SLX4 and MUS81 | Descriptor: | GLYCINE, MUS81 endonuclease homolog (Yeast), isoform CRA_b, ... | Authors: | Wan, B, Wu, J, Lei, M. | Deposit date: | 2020-04-04 | Release date: | 2021-04-07 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | SLX4 control MUS81 endonuclease function in telomere through an intermolecular SAP domain To be published
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7C7A
| Cryo-EM structure of yeast Ribonuclease MRP with substrate ITS1 | Descriptor: | Internal Transcribed Spacer 1, MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, ... | Authors: | Lan, P, Wu, J, Lei, M. | Deposit date: | 2020-05-24 | Release date: | 2020-07-08 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural insight into precursor ribosomal RNA processing by ribonuclease MRP. Science, 369, 2020
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7C79
| Cryo-EM structure of yeast Ribonuclease MRP | Descriptor: | MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, Ribonuclease MRP RNA subunit NME1, ... | Authors: | Lan, P, Wu, J, Lei, M. | Deposit date: | 2020-05-24 | Release date: | 2020-07-08 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural insight into precursor ribosomal RNA processing by ribonuclease MRP. Science, 369, 2020
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