7WRA
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![BU of 7wra by Molmil](/molmil-images/mine/7wra) | Mouse TRPM8 in LMNG in ligand-free state | Descriptor: | SODIUM ION, Transient receptor potential cation channel subfamily M member 8 | Authors: | Zhao, C, Xie, Y, Guo, J. | Deposit date: | 2022-01-26 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structures of a mammalian TRPM8 in closed state. Nat Commun, 13, 2022
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7WRD
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7WRF
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![BU of 7wrf by Molmil](/molmil-images/mine/7wrf) | Mouse TRPM8 in lipid nanodiscs in the presence of calcium, icilin and PI(4,5)P2 | Descriptor: | CALCIUM ION, Icilin, SODIUM ION, ... | Authors: | Zhao, C, Xie, Y, Guo, J. | Deposit date: | 2022-01-26 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Structures of a mammalian TRPM8 in closed state. Nat Commun, 13, 2022
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7WRB
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7WRC
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![BU of 7wrc by Molmil](/molmil-images/mine/7wrc) | Mouse TRPM8 in LMNG in the presence of calcium, icilin and PI(4,5)P2 | Descriptor: | CALCIUM ION, Icilin, Transient receptor potential cation channel subfamily M member 8 | Authors: | Zhao, C, Xie, Y, Guo, J. | Deposit date: | 2022-01-26 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Structures of a mammalian TRPM8 in closed state. Nat Commun, 13, 2022
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7WRE
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3NCO
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![BU of 3nco by Molmil](/molmil-images/mine/3nco) | Crystal structure of FnCel5A from F. nodosum Rt17-B1 | Descriptor: | Endoglucanase FnCel5A, PHOSPHATE ION, peptide (ALA)(ASN)(GLU), ... | Authors: | Zheng, B.S, Yang, W, Wang, Y, Lou, Z.Y, Rao, Z.H, Feng, Y. | Deposit date: | 2010-06-05 | Release date: | 2011-06-22 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of FnCel5A from F. nodosum Rt17-B1 To be Published
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7VHQ
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![BU of 7vhq by Molmil](/molmil-images/mine/7vhq) | Structural insights into the membrane microdomain organization by SPFH family proteins | Descriptor: | ATP-dependent zinc metalloprotease FtsH, Modulator of FtsH protease HflC, Protein HflK | Authors: | Ma, C.Y, Wang, C.K, Luo, D.Y, Yan, L, Yang, W.X, Li, N.N, Gao, N. | Deposit date: | 2021-09-22 | Release date: | 2022-01-19 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Structural insights into the membrane microdomain organization by SPFH family proteins. Cell Res., 32, 2022
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7XBW
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![BU of 7xbw by Molmil](/molmil-images/mine/7xbw) | Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with Gi1 | Descriptor: | CHOLESTEROL, CX3C chemokine receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q. | Deposit date: | 2022-03-22 | Release date: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Activation of the human chemokine receptor CX3CR1 regulated by cholesterol. Sci Adv, 8, 2022
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7VHP
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![BU of 7vhp by Molmil](/molmil-images/mine/7vhp) | Structural insights into the membrane microdomain organization by SPFH family proteins | Descriptor: | ATP-dependent zinc metalloprotease FtsH, Modulator of FtsH protease HflC, Protein HflK | Authors: | Ma, C.Y, Wang, C.K, Luo, D.Y, Yan, L, Yang, W.X, Li, N.N, Gao, N. | Deposit date: | 2021-09-22 | Release date: | 2022-03-23 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Structural insights into the membrane microdomain organization by SPFH family proteins. Cell Res., 32, 2022
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7XBX
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![BU of 7xbx by Molmil](/molmil-images/mine/7xbx) | Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and Gi1 | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q. | Deposit date: | 2022-03-22 | Release date: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Activation of the human chemokine receptor CX3CR1 regulated by cholesterol. Sci Adv, 8, 2022
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2HX4
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![BU of 2hx4 by Molmil](/molmil-images/mine/2hx4) | Rat nNOS heme domain complexed with 4-N-(Nw-nitro-L-argininyl)-trans-4-hydroxyamino-L-proline amide | Descriptor: | (4R)-4-(HYDROXY{N~5~-[IMINO(NITROAMINO)METHYL]-L-ORNITHYL}AMINO)-L-PROLINAMIDE, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | Authors: | Igarashi, J, Li, H, Poulos, T.L. | Deposit date: | 2006-08-02 | Release date: | 2007-04-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water. J.Med.Chem., 50, 2007
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2HX2
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![BU of 2hx2 by Molmil](/molmil-images/mine/2hx2) | Bovine eNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine | Descriptor: | (4S)-N-{4-AMINO-5-[(2-AMINOETHYL)(HYDROXYAMINO]-PENTYL}-N'-NITROGUANIDINE, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | Authors: | Igarashi, J, Li, H, Poulos, T.L. | Deposit date: | 2006-08-02 | Release date: | 2007-04-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water. J.Med.Chem., 50, 2007
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2HX3
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![BU of 2hx3 by Molmil](/molmil-images/mine/2hx3) | Rat nNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine | Descriptor: | (4S)-N-{4-AMINO-5-[(2-AMINOETHYL)(HYDROXYAMINO]-PENTYL}-N'-NITROGUANIDINE, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | Authors: | Igarashi, J, Li, H, Poulos, T.L. | Deposit date: | 2006-08-02 | Release date: | 2007-04-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water. J.Med.Chem., 50, 2007
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7VOJ
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![BU of 7voj by Molmil](/molmil-images/mine/7voj) | Al-bound structure of the AtALMT1 mutant M60A | Descriptor: | ACETIC ACID, ALUMINUM ION, Aluminum-activated malate transporter 1 | Authors: | Wang, J. | Deposit date: | 2021-10-14 | Release date: | 2021-12-01 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of ALMT1-mediated aluminum resistance in Arabidopsis. Cell Res., 32, 2022
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7VQ5
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7VQ3
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7VQ4
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7VQ7
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![BU of 7vq7 by Molmil](/molmil-images/mine/7vq7) | The Al-bound AtALMT1 structure at pH 5 (ALMT1Al/pH5) | Descriptor: | ALUMINUM ION, Aluminum-activated malate transporter 1 | Authors: | Wang, J.Q. | Deposit date: | 2021-10-19 | Release date: | 2021-12-01 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis of ALMT1-mediated aluminum resistance in Arabidopsis. Cell Res., 32, 2022
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7XNK
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![BU of 7xnk by Molmil](/molmil-images/mine/7xnk) | human KCNQ1-CaM in complex with ML277 | Descriptor: | (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide, Calmodulin-3, POTASSIUM ION, ... | Authors: | Ma, D, Guo, J. | Deposit date: | 2022-04-29 | Release date: | 2022-12-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers. Proc.Natl.Acad.Sci.USA, 119, 2022
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7XNL
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![BU of 7xnl by Molmil](/molmil-images/mine/7xnl) | human KCNQ1-CaM-ML277-PIP2 complex in state A | Descriptor: | (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide, Calmodulin-3, POTASSIUM ION, ... | Authors: | Ma, D, Guo, J. | Deposit date: | 2022-04-29 | Release date: | 2022-12-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers. Proc.Natl.Acad.Sci.USA, 119, 2022
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7XNI
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![BU of 7xni by Molmil](/molmil-images/mine/7xni) | human KCNQ1-CaM in apo state | Descriptor: | Calmodulin-3, Potassium voltage-gated channel subfamily KQT member 1 | Authors: | Ma, D, Guo, J. | Deposit date: | 2022-04-28 | Release date: | 2022-12-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers. Proc.Natl.Acad.Sci.USA, 119, 2022
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7XNN
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![BU of 7xnn by Molmil](/molmil-images/mine/7xnn) | human KCNQ1-CaM-ML277-PIP2 complex in state B | Descriptor: | (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide, Calmodulin-3, POTASSIUM ION, ... | Authors: | Ma, D, Guo, J. | Deposit date: | 2022-04-29 | Release date: | 2022-12-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers. Proc.Natl.Acad.Sci.USA, 119, 2022
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6KUU
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![BU of 6kuu by Molmil](/molmil-images/mine/6kuu) | Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B3) | Descriptor: | 3'-vRNA, 5'-vRNA, Polymerase 3, ... | Authors: | Peng, Q, Peng, R, Qi, J, Gao, G.F, Shi, Y. | Deposit date: | 2019-09-02 | Release date: | 2019-12-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B3) To Be Published
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4QM0
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![BU of 4qm0 by Molmil](/molmil-images/mine/4qm0) | Crystal structure of RORc in complex with a tertiary sulfonamide inverse agonist | Descriptor: | DIMETHYL SULFOXIDE, N-(2-methylpropyl)-N-({5-[4-(methylsulfonyl)phenyl]thiophen-2-yl}methyl)-1-phenylmethanesulfonamide, Nuclear receptor ROR-gamma | Authors: | Boenig, G, Hymowitz, S.G, Wang, W. | Deposit date: | 2014-06-14 | Release date: | 2014-09-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.195 Å) | Cite: | Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists. Bioorg.Med.Chem.Lett., 24, 2014
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