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Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
Descriptor:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
Authors:	McGowan, S.
Deposit date:	2013-04-15
Release date:	2013-06-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.91 Å)
Cite:	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4K5M

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
Descriptor:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
Authors:	McGowan, S.
Deposit date:	2013-04-14
Release date:	2013-06-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4K5L

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
Descriptor:	M1 family aminopeptidase, MAGNESIUM ION, ZINC ION, ...
Authors:	McGowan, S.
Deposit date:	2013-04-14
Release date:	2013-06-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.91 Å)
Cite:	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4K3N

Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum
Descriptor:	CARBONATE ION, M17 leucyl aminopeptidase, NONAETHYLENE GLYCOL, ...
Authors:	McGowan, S.
Deposit date:	2013-04-11
Release date:	2013-06-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4ZX5

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10q
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW5

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9f
Descriptor:	M1 family aminopeptidase, MAGNESIUM ION, ZINC ION, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-19
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW6

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9q
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-19
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW3

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9b
Descriptor:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-19
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX6

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10s
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZY2

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10o
Descriptor:	CARBONATE ION, DIMETHYL SULFOXIDE, N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluorobiphenyl-4-yl)ethyl]-2,2-dimethylpropanamide, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-21
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW8

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9r
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-19
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZY0

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10q
Descriptor:	CARBONATE ION, GLYCEROL, N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(thiophen-3-yl)phenyl]ethyl}-2,2-dimethylpropanamide, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-21
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX9

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10b
Descriptor:	CARBONATE ION, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW7

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9m
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-19
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZYQ

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10s
Descriptor:	CARBONATE ION, N-{(1R)-2-(hydroxyamino)-1-[3'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl]-2-oxoethyl}-2,2-dimethylpropanamide, PENTAETHYLENE GLYCOL, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-22
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX4

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10o
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX8

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 9b
Descriptor:	CARBONATE ION, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX3

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10b
Descriptor:	DIMETHYL SULFOXIDE, M1 family aminopeptidase, MAGNESIUM ION, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZY1

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10r
Descriptor:	CARBONATE ION, GLYCEROL, N-{(1R)-2-(hydroxyamino)-1-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-2-oxoethyl}-2,2-dimethylpropanamide, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-21
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

5QKC

Group deposition of library data - Crystal Structure of EcDsbA after initial refinement with no ligand modelled (structure A1_1)
Descriptor:	Thiol:disulfide interchange protein
Authors:	Ilyichova, O.V, Bentley, M.R, Doak, B.C, Scanlon, M.J.
Deposit date:	2019-01-27
Release date:	2020-02-05
Last modified:	2024-04-24
Method:	X-RAY DIFFRACTION (2.146 Å)
Cite:	Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX). J.Med.Chem., 63, 2020

5QKS

Group deposition of library data - Crystal Structure of EcDsbA after initial refinement with no ligand modelled (structure A8_1)
Descriptor:	Thiol:disulfide interchange protein
Authors:	Ilyichova, O.V, Bentley, M.R, Doak, B.C, Scanlon, M.J.
Deposit date:	2019-01-27
Release date:	2020-02-05
Last modified:	2020-07-22
Method:	X-RAY DIFFRACTION (2.118 Å)
Cite:	Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX). J.Med.Chem., 63, 2020

5QL9

Group deposition of library data - Crystal Structure of EcDsbA after initial refinement with no ligand modelled (structure B9_2)
Descriptor:	Thiol:disulfide interchange protein
Authors:	Ilyichova, O.V, Bentley, M.R, Doak, B.C, Scanlon, M.J.
Deposit date:	2019-01-27
Release date:	2020-02-05
Last modified:	2020-07-22
Method:	X-RAY DIFFRACTION (2.151 Å)
Cite:	Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX). J.Med.Chem., 63, 2020

5QLS

Group deposition of library data - Crystal Structure of EcDsbA after initial refinement with no ligand modelled (structure D11_1)
Descriptor:	Thiol:disulfide interchange protein
Authors:	Ilyichova, O.V, Bentley, M.R, Doak, B.C, Scanlon, M.J.
Deposit date:	2019-01-27
Release date:	2020-02-05
Last modified:	2020-07-22
Method:	X-RAY DIFFRACTION (2.007 Å)
Cite:	Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX). J.Med.Chem., 63, 2020

5QM7

Group deposition of library data - Crystal Structure of EcDsbA after initial refinement with no ligand modelled (structure E2_1)
Descriptor:	Thiol:disulfide interchange protein
Authors:	Ilyichova, O.V, Bentley, M.R, Doak, B.C, Scanlon, M.J.
Deposit date:	2019-01-27
Release date:	2020-02-05
Last modified:	2020-07-22
Method:	X-RAY DIFFRACTION (2.037 Å)
Cite:	Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX). J.Med.Chem., 63, 2020

5QKI

Group deposition of library data - Crystal Structure of EcDsbA after initial refinement with no ligand modelled (structure A2_2)
Descriptor:	Thiol:disulfide interchange protein
Authors:	Ilyichova, O.V, Bentley, M.R, Doak, B.C, Scanlon, M.J.
Deposit date:	2019-01-27
Release date:	2020-02-05
Last modified:	2020-07-22
Method:	X-RAY DIFFRACTION (2.304 Å)
Cite:	Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX). J.Med.Chem., 63, 2020

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Displayed results:	25
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