6BF9
 
 | | Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain | | Descriptor: | Fab H11-E heavy chain, Fab H11-E light chain, Insulin-degrading enzyme | | Authors: | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | | Deposit date: | 2017-10-26 | | Release date: | 2018-02-07 | | Last modified: | 2021-04-28 | | Method: | ELECTRON MICROSCOPY (7.2 Å) | | Cite: | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
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6BF7
 | | Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain | | Descriptor: | Fab H11-E heavy chain, Fab H11-E light chain, Insulin-degrading enzyme | | Authors: | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | | Deposit date: | 2017-10-26 | | Release date: | 2018-02-07 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (6.5 Å) | | Cite: | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
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1BP3
 | | THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX | | Descriptor: | PROTEIN (GROWTH HORMONE), PROTEIN (PROLACTIN RECEPTOR), ZINC ION | | Authors: | Somers, W, Ultsch, M, De Vos, A.M, Kossiakoff, A.A. | | Deposit date: | 1998-08-12 | | Release date: | 1998-08-19 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The X-ray structure of a growth hormone-prolactin receptor complex.
Nature, 372, 1994
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1AAP
 | | X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR | | Descriptor: | ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN | | Authors: | Hynes, T.R, Randal, M, Kennedy, L.A, Eigenbrot, C, Kossiakoff, A.A. | | Deposit date: | 1990-09-14 | | Release date: | 1991-10-15 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
Biochemistry, 29, 1990
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5UEA
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5UEK
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1TAW
 | | BOVINE TRYPSIN COMPLEXED TO APPI | | Descriptor: | CALCIUM ION, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR, TRYPSIN | | Authors: | Hynes, T.R, Kossiakoff, A.A. | | Deposit date: | 1996-12-19 | | Release date: | 1997-06-24 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6, 1997
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5EII
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1FYH
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1F6F
 | | CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR | | Descriptor: | PLACENTAL LACTOGEN, PROLACTIN RECEPTOR | | Authors: | Elkins, P.A, Christinger, H.W, Sandowski, Y, Sakal, E, Gertler, A, De Vos, A.M, Kossiakoff, A.A. | | Deposit date: | 2000-06-21 | | Release date: | 2000-07-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Nat.Struct.Biol., 7, 2000
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7ZLG
 | | Cryo-EM structure of C-mannosyltransferase CeDPY19, in complex with acceptor peptide and bound to CMT2-Fab and anti-Fab nanobody | | Descriptor: | Anti-Fab nanobody, C-mannosyltransferase dpy-19, CMT2-Fab heavy chain, ... | | Authors: | Bloch, J.S, Mukherjee, S, Mao, R, Irobalieva, R, Kossiakoff, A.A, Goddard-Borger, E.D, Locher, K.P. | | Deposit date: | 2022-04-15 | | Release date: | 2023-01-11 | | Last modified: | 2023-05-10 | | Method: | ELECTRON MICROSCOPY (2.72 Å) | | Cite: | Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
Nat.Chem.Biol., 19, 2023
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7ZLJ
 | | Cryo-EM structure of C-mannosyltransferase CeDPY19, in ternary complex with Dol25-P-C-Man and acceptor peptide, bound to CMT2-Fab and anti-Fab nanobody | | Descriptor: | Anti-Fab nanobody, C-mannosyltransferase dpy-19, CMT2-Fab heavy chain, ... | | Authors: | Bloch, J.S, Mao, R, Mukherjee, S, Boilevin, J, Irobalieva, R, Darbre, T, Reymond, J.L, Kossiakoff, A.A, Goddard-Borger, E.D, Locher, K.P. | | Deposit date: | 2022-04-15 | | Release date: | 2023-01-11 | | Last modified: | 2023-05-10 | | Method: | ELECTRON MICROSCOPY (3.63 Å) | | Cite: | Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
Nat.Chem.Biol., 19, 2023
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7ZLH
 | | Cryo-EM structure of C-mannosyltransferase CeDPY19, in apo state, bound to CMT2-Fab and anti-Fab nanobody | | Descriptor: | Anti-Fab nanobody, C-mannosyltransferase dpy-19, CMT2-Fab heavy chain, ... | | Authors: | Bloch, J.S, Mukherjee, S, Irobalieva, R, Kossiakoff, A.A, Goddard-Borger, E.D, Locher, K.P. | | Deposit date: | 2022-04-15 | | Release date: | 2023-01-11 | | Last modified: | 2023-05-10 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
Nat.Chem.Biol., 19, 2023
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7ZLI
 | | Cryo-EM structure of C-mannosyltransferase CeDPY19, in complex with Dol25-P-Man and bound to CMT2-Fab and anti-Fab nanobody | | Descriptor: | Anti-Fab nanobody, C-mannosyltransferase dpy-19, CMT2-Fab heavy chain, ... | | Authors: | Bloch, J.S, Mukherjee, S, Boilevin, J, Irobalieva, R, Darbre, T, Reymond, J.L, Kossiakoff, A.A, Goddard-Borger, E.D, Locher, K.P. | | Deposit date: | 2022-04-15 | | Release date: | 2023-01-11 | | Last modified: | 2023-05-10 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
Nat.Chem.Biol., 19, 2023
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7ZYI
 | | Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody | | Descriptor: | CHOLESTEROL, GLYCOCHENODEOXYCHOLIC ACID, Nanobody, ... | | Authors: | Liu, H, Irobalieva, R.N, Bang-Sorensen, R, Nosol, K, Mukherjee, S, Agrawal, P, Stieger, B, Kossiakoff, A.A, Locher, K.P. | | Deposit date: | 2022-05-24 | | Release date: | 2022-07-13 | | Last modified: | 2022-08-10 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.
Cell Res., 32, 2022
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8SLB
 | | X-ray structure of CorA N-terminal domain in complex with conformation-specific synthetic antibody C12 | | Descriptor: | CHLORIDE ION, Cobalt/magnesium transport protein CorA, sAB C12 Heavy Chain, ... | | Authors: | Dominik, P.K, Erramilli, S.K, Reddy, B.G, Kossiakoff, A.A. | | Deposit date: | 2023-04-21 | | Release date: | 2023-06-07 | | Last modified: | 2023-07-26 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Conformation-specific Synthetic Antibodies Discriminate Multiple Functional States of the Ion Channel CorA.
J.Mol.Biol., 435, 2023
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2FCS
 | | X-ray Crystal Structure of a Chemically Synthesized [L-Gln35]Ubiquitin with a Cubic Space Group | | Descriptor: | ACETATE ION, CADMIUM ION, SULFATE ION, ... | | Authors: | Bang, D, Gribenko, A.V, Tereshko, V, Kossiakoff, A.A, Kent, S.B, Makhatadze, G.I. | | Deposit date: | 2005-12-12 | | Release date: | 2006-01-31 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis.
Nat.Chem.Biol., 2, 2006
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1YJ1
 | | X-ray Crystal Structure of a Chemically Synthesized [D-Gln35]Ubiquitin | | Descriptor: | CADMIUM ION, CHLORIDE ION, Ubiquitin | | Authors: | Bang, D, Makhatadze, G.I, Tereshko, V, Kossiakoff, A.A, Kent, S.B. | | Deposit date: | 2005-01-13 | | Release date: | 2005-06-14 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | X-ray Crystal Structure of a Chemically Synthesized [D-Gln35]Ubiquitin
Angew.Chem.Int.Ed.Engl., 44, 2005
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2FCN
 | | X-ray Crystal Structure of a Chemically Synthesized [D-Val35]Ubiquitin with a Cubic Space Group | | Descriptor: | ACETATE ION, CADMIUM ION, Ubiquitin | | Authors: | Bang, D, Gribenko, A.V, Tereshko, V, Kossiakoff, A.A, Kent, S.B, Makhatadze, G.I. | | Deposit date: | 2005-12-12 | | Release date: | 2006-01-31 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis.
Nat.Chem.Biol., 2, 2006
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1Z7C
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2HV2
 | | Crystal Structure of Conserved Protein of Unknown Function from Enterococcus faecalis V583 at 2.4 A Resolution, Probable N-Acyltransferase | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Hypothetical protein, TETRAETHYLENE GLYCOL | | Authors: | Tereshko, V.A, Qiu, Y, Kossiakoff, A.A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2006-07-27 | | Release date: | 2006-08-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of conserved hypothetical protein from Enterococcus faecalis V583 at 2.4 A resolution.
To be Published
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1Y3T
 | | Crystal structure of YxaG, a dioxygenase from Bacillus subtilis | | Descriptor: | FE (III) ION, Hypothetical protein yxaG | | Authors: | Gopal, B, Madan, L.L, Betz, S.F, Kossiakoff, A.A. | | Deposit date: | 2004-11-26 | | Release date: | 2005-01-18 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The Crystal Structure of a Quercetin 2,3-Dioxygenase from Bacillus subtilis Suggests Modulation of Enzyme Activity by a Change in the Metal Ion at the Active Site(s)
Biochemistry, 44, 2005
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1YIW
 | | X-ray Crystal Structure of a Chemically Synthesized Ubiquitin | | Descriptor: | CADMIUM ION, CHLORIDE ION, Ubiquitin | | Authors: | Bang, D, Makhatadze, G.I, Tereshko, V, Kossiakoff, A.A, Kent, S.B. | | Deposit date: | 2005-01-13 | | Release date: | 2005-06-14 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | X-ray Crystal Structure of a Chemically Synthesized [D-Gln35]Ubiquitin
Angew.Chem.Int.Ed.Engl., 44, 2005
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2FXU
 | | X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution. | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Rizvi, S.A, Tereshko, V, Kossiakoff, A.A, Kozmin, S.A. | | Deposit date: | 2006-02-06 | | Release date: | 2006-03-07 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Structure of bistramide a-actin complex at a 1.35 A resolution
J.Am.Chem.Soc., 128, 2006
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4JQI
 | | Structure of active beta-arrestin1 bound to a G protein-coupled receptor phosphopeptide | | Descriptor: | 1,2-ETHANEDIOL, Beta-arrestin-1, CHLORIDE ION, ... | | Authors: | Shukla, A.K, Manglik, A, Kruse, A.C, Xiao, K, Reis, R.I, Tseng, W.C, Staus, D.P, Hilger, D, Uysal, S, Huang, L.H, Paduch, M, Shukla, P.T, Koide, A, Koide, S, Weis, W.I, Kossiakoff, A.A, Kobilka, B.K, Lefkowitz, R.J. | | Deposit date: | 2013-03-20 | | Release date: | 2013-04-17 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of active beta-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
Nature, 497, 2013
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