5Y94
 
 | | Crystal Structure Analysis of the BRD4 | | Descriptor: | 5-bromanyl-2-methoxy-N-[3-methyl-6-(methylamino)-1,2-benzoxazol-5-yl]benzenesulfonamide, Bromodomain-containing protein 4, GLYCEROL, ... | | Authors: | Xu, Y, Zhang, Y, Song, M, Wang, C. | | Deposit date: | 2017-08-22 | | Release date: | 2018-06-13 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)
J. Med. Chem., 61, 2018
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5Y8Z
 | | Crystal Structure Analysis of the BRD4 | | Descriptor: | 1,2-ETHANEDIOL, 5-bromanyl-N-(3,6-dimethyl-1,2-benzoxazol-5-yl)-2-methoxy-benzenesulfonamide, Bromodomain-containing protein 4, ... | | Authors: | Xu, Y, Zhang, Y, Song, M, Wang, C. | | Deposit date: | 2017-08-22 | | Release date: | 2018-06-13 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)
J. Med. Chem., 61, 2018
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5HMB
 | | Crystal structure of S. sahachiroi AziG | | Descriptor: | Azi13, SULFATE ION | | Authors: | Erb, M.S, Zhang, Y, Ealick, S.E. | | Deposit date: | 2016-01-15 | | Release date: | 2016-02-03 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.151 Å) | | Cite: | Polyketide Ring Expansion Mediated by a Thioesterase, Chain Elongation and Cyclization Domain, in Azinomycin Biosynthesis: Characterization of AziB and AziG.
Biochemistry, 55, 2016
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5X58
 | | Prefusion structure of SARS-CoV spike glycoprotein, conformation 1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | Authors: | Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F. | | Deposit date: | 2017-02-15 | | Release date: | 2017-05-03 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
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5X5B
 | | Prefusion structure of SARS-CoV spike glycoprotein, conformation 2 | | Descriptor: | Spike glycoprotein | | Authors: | Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F. | | Deposit date: | 2017-02-15 | | Release date: | 2017-05-03 | | Last modified: | 2017-05-24 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
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5X59
 | | Prefusion structure of MERS-CoV spike glycoprotein, three-fold symmetry | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S protein | | Authors: | Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F. | | Deposit date: | 2017-02-15 | | Release date: | 2017-05-03 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
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5X5C
 | | Prefusion structure of MERS-CoV spike glycoprotein, conformation 1 | | Descriptor: | S protein | | Authors: | Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F. | | Deposit date: | 2017-02-15 | | Release date: | 2017-05-03 | | Last modified: | 2017-05-24 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
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5X5F
 | | Prefusion structure of MERS-CoV spike glycoprotein, conformation 2 | | Descriptor: | S protein | | Authors: | Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F. | | Deposit date: | 2017-02-15 | | Release date: | 2017-05-03 | | Last modified: | 2017-05-24 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
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5YQX
 | | Crystal Structure Analysis of the BRD4 | | Descriptor: | (2R)-2-(cyclopropylmethyl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-4H-1,4-benzoxazin-3-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ... | | Authors: | Xue, X, Zhang, Y, Wang, C, Song, M. | | Deposit date: | 2017-11-08 | | Release date: | 2018-11-28 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer.
Eur.J.Med.Chem., 152, 2018
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1C24
 | | E. COLI METHIONINE AMINOPEPTIDASE: METHIONINE PHOSPHINATE COMPLEX | | Descriptor: | (1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHINIC ACID, COBALT (II) ION, METHIONINE AMINOPEPTIDASE, ... | | Authors: | Lowther, W.T, Zhang, Y, Sampson, P.B, Honek, J.F, Matthews, B.W. | | Deposit date: | 1999-07-22 | | Release date: | 1999-11-17 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
Biochemistry, 38, 1999
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1C21
 | | E. COLI METHIONINE AMINOPEPTIDASE: METHIONINE COMPLEX | | Descriptor: | COBALT (II) ION, METHIONINE, METHIONINE AMINOPEPTIDASE, ... | | Authors: | Lowther, W.T, Zhang, Y, Sampson, P.B, Honek, J.F, Matthews, B.W. | | Deposit date: | 1999-07-22 | | Release date: | 1999-11-17 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
Biochemistry, 38, 1999
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1C22
 | | E. COLI METHIONINE AMINOPEPTIDASE: TRIFLUOROMETHIONINE COMPLEX | | Descriptor: | 2-AMINO-4-TRIFLUOROMETHYLSULFANYL-BUTYRIC ACID, COBALT (II) ION, METHIONINE AMINOPEPTIDASE, ... | | Authors: | Lowther, W.T, Zhang, Y, Sampson, P.B, Honek, J.F, Matthews, B.W. | | Deposit date: | 1999-07-22 | | Release date: | 1999-11-17 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
Biochemistry, 38, 1999
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1C23
 | | E. COLI METHIONINE AMINOPEPTIDASE: METHIONINE PHOSPHONATE COMPLEX | | Descriptor: | (1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHONIC ACID, COBALT (II) ION, METHIONINE AMINOPEPTIDASE, ... | | Authors: | Lowther, W.T, Zhang, Y, Sampson, P.B, Honek, J.F, Matthews, B.W. | | Deposit date: | 1999-07-22 | | Release date: | 1999-11-17 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
Biochemistry, 38, 1999
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1C27
 | | E. COLI METHIONINE AMINOPEPTIDASE:NORLEUCINE PHOSPHONATE COMPLEX | | Descriptor: | (1-AMINO-PENTYL)-PHOSPHONIC ACID, COBALT (II) ION, METHIONINE AMINOPEPTIDASE, ... | | Authors: | Lowther, W.T, Zhang, Y, Sampson, P.B, Honek, J.F, Matthews, B.W. | | Deposit date: | 1999-07-22 | | Release date: | 1999-11-17 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
Biochemistry, 38, 1999
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1F46
 | | THE BACTERIAL CELL-DIVISION PROTEIN ZIPA AND ITS INTERACTION WITH AN FTSZ FRAGMENT REVEALED BY X-RAY CRYSTALLOGRAPHY | | Descriptor: | CELL DIVISION PROTEIN ZIPA | | Authors: | Mosyak, L, Zhang, Y, Glasfeld, E, Stahl, M, Somers, W.S. | | Deposit date: | 2000-06-07 | | Release date: | 2001-06-13 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The bacterial cell-division protein ZipA and its interaction with an FtsZ fragment revealed by X-ray crystallography.
EMBO J., 19, 2000
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1F47
 | | THE BACTERIAL CELL-DIVISION PROTEIN ZIPA AND ITS INTERACTION WITH AN FTSZ FRAGMENT REVEALED BY X-RAY CRYSTALLOGRAPHY | | Descriptor: | CELL DIVISION PROTEIN FTSZ, CELL DIVISION PROTEIN ZIPA | | Authors: | Mosyak, L, Zhang, Y, Glasfeld, E, Stahl, M, Somers, W.S. | | Deposit date: | 2000-06-07 | | Release date: | 2001-06-13 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | The bacterial cell-division protein ZipA and its interaction with an FtsZ fragment revealed by X-ray crystallography.
EMBO J., 19, 2000
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1UO5
 | | Structure Based Engineering of Internal Molecular Surfaces Of Four Helix Bundles | | Descriptor: | CHLORIDE ION, GENERAL CONTROL PROTEIN GCN4, iodobenzene | | Authors: | Yadav, M.K, Redman, J.E, Alvarez-Gutierrez, J.M, Zhang, Y. | | Deposit date: | 2003-09-15 | | Release date: | 2004-10-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Structure-Based Engineering of Internal Cavities in Coiled-Coil Peptides
Biochemistry, 44, 2005
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5X4R
 | | Structure of the N-terminal domain (NTD) of MERS-CoV spike protein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S protein | | Authors: | Yuan, Y, Zhang, Y, Qi, J, Shi, Y, Gao, G.F. | | Deposit date: | 2017-02-14 | | Release date: | 2017-05-03 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
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3JA8
 | | Cryo-EM structure of the MCM2-7 double hexamer | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Minichromosome Maintenance 2, Minichromosome Maintenance 3, ... | | Authors: | Li, N, Zhai, Y, Zhang, Y, Li, W, Yang, M, Lei, J, Tye, B.K, Gao, N. | | Deposit date: | 2015-05-09 | | Release date: | 2015-08-05 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of the eukaryotic MCM complex at 3.8 angstrom
Nature, 524, 2015
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3JCS
 | | 2.8 Angstrom cryo-EM structure of the large ribosomal subunit from the eukaryotic parasite Leishmania | | Descriptor: | 26S alpha ribosomal RNA, 26S delta ribosomal RNA, 26S epsilon ribosomal RNA, ... | | Authors: | Shalev-Benami, M, Zhang, Y, Matzov, D, Halfon, Y, Zackay, A, Rozenberg, H, Zimmerman, E, Bashan, A, Jaffe, C.L, Yonath, A, Skiniotis, G. | | Deposit date: | 2016-01-21 | | Release date: | 2016-07-20 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | 2.8- angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.
Cell Rep, 16, 2016
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5X4S
 | | Structure of the N-terminal domain (NTD)of SARS-CoV spike protein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | Authors: | Yuan, Y, Zhang, Y, Qi, J, Shi, Y, Gao, G.F. | | Deposit date: | 2017-02-14 | | Release date: | 2017-05-03 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
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1MSV
 | | The S68A S-adenosylmethionine decarboxylase proenzyme processing mutant. | | Descriptor: | 1,4-DIAMINOBUTANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, S-adenosylmethionine decarboxylase proenzyme | | Authors: | Tolbert, W.D, Zhang, Y, Bennett, E.M, Cottet, S.E, Ekstrom, J.L, Pegg, A.E, Ealick, S.E. | | Deposit date: | 2002-09-19 | | Release date: | 2003-03-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Mechanism of Human S-Adenosylmethionine
Decarboxylase Proenzyme Processing as Revealed by the
Structure of the S68A Mutant.
Biochemistry, 42, 2003
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1L3K
 | | UP1, THE TWO RNA-RECOGNITION MOTIF DOMAIN OF HNRNP A1 | | Descriptor: | HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1 | | Authors: | Vitali, J, Ding, J, Jiang, J, Zhang, Y, Krainer, A.R, Xu, R.-M. | | Deposit date: | 2002-02-27 | | Release date: | 2002-04-17 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1.
Nucleic Acids Res., 30, 2002
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1UNX
 | | Structure Based Engineering of Internal Molecular Surfaces Of Four Helix Bundles | | Descriptor: | GENERAL CONTROL PROTEIN GCN4 | | Authors: | Yadav, M.K, Redman, J.E, Alvarez-Gutierrez, J.M, Zhang, Y, Stout, C.D, Ghadiri, M.R. | | Deposit date: | 2003-09-15 | | Release date: | 2004-10-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure-Based Engineering of Internal Cavities in Coiled-Coil Peptides
Biochemistry, 44, 2005
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1UO1
 | | Structure Based Engineering of Internal Molecular Surfaces Of Four Helix Bundles | | Descriptor: | GENERAL CONTROL PROTEIN GCN4 | | Authors: | Yadav, M.K, Redman, J.E, Alvarez-Gutierrez, J.M, Zhang, Y, Stout, C.D, Ghadiri, M.R. | | Deposit date: | 2003-09-15 | | Release date: | 2004-10-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure-Based Engineering of Internal Cavities in Coiled-Coil Peptides
Biochemistry, 44, 2005
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