6PO1
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![BU of 6po1 by Molmil](/molmil-images/mine/6po1) | ClpX-ClpP complex bound to substrate and ATP-gamma-S, class 4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, ... | Authors: | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | Deposit date: | 2019-07-03 | Release date: | 2020-03-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife, 9, 2020
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6PP8
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![BU of 6pp8 by Molmil](/molmil-images/mine/6pp8) | ClpX in ClpX-ClpP complex bound to substrate and ATP-gamma-S, class 1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | Deposit date: | 2019-07-05 | Release date: | 2020-03-11 | Method: | ELECTRON MICROSCOPY (4.12 Å) | Cite: | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife, 9, 2020
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6PP6
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![BU of 6pp6 by Molmil](/molmil-images/mine/6pp6) | ClpX in ClpX-ClpP complex bound to substrate and ATP-gamma-S, class 3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | Deposit date: | 2019-07-05 | Release date: | 2020-03-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.28 Å) | Cite: | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife, 9, 2020
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6PXI
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![BU of 6pxi by Molmil](/molmil-images/mine/6pxi) | The crystal structure of a singly capped HslUV complex with an axial pore plug and a HslU E257Q mutation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent protease ATPase subunit HslU, ATP-dependent protease subunit HslV, ... | Authors: | Baytshtok, V, Grant, R.A, Sauer, R.T. | Deposit date: | 2019-07-26 | Release date: | 2020-07-29 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (3.447 Å) | Cite: | Heat activates the AAA+ HslUV protease by melting an axial autoinhibitory plug. Cell Rep, 34, 2021
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4U0G
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![BU of 4u0g by Molmil](/molmil-images/mine/4u0g) | Crystal Structure of M. tuberculosis ClpP1P2 bound to ADEP and agonist | Descriptor: | ADEP-2B5Me, ATP-dependent Clp protease proteolytic subunit 1, ATP-dependent Clp protease proteolytic subunit 2, ... | Authors: | Schmitz, K.R, Carney, D.W, Sello, J.K, Sauer, R.T. | Deposit date: | 2014-07-11 | Release date: | 2014-10-08 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.1978 Å) | Cite: | Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery. Proc.Natl.Acad.Sci.USA, 111, 2014
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4U0H
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![BU of 4u0h by Molmil](/molmil-images/mine/4u0h) | Crystal Structure of M. tuberculosis ClpP1P1 | Descriptor: | ATP-dependent Clp protease proteolytic subunit 1, SULFATE ION | Authors: | Schmitz, K.R, Carney, D.W, Sello, J.K, Sauer, R.T. | Deposit date: | 2014-07-11 | Release date: | 2014-10-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.2479 Å) | Cite: | Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery. Proc.Natl.Acad.Sci.USA, 111, 2014
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5TXV
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![BU of 5txv by Molmil](/molmil-images/mine/5txv) | HslU P21 cell with 4 hexamers | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent protease ATPase subunit HslU | Authors: | Grant, R.A, Chen, J, Glynn, S.E, Sauer, R.T. | Deposit date: | 2016-11-17 | Release date: | 2017-03-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (7.086 Å) | Cite: | Covalently linked HslU hexamers support a probabilistic mechanism that links ATP hydrolysis to protein unfolding and translocation. J. Biol. Chem., 292, 2017
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5TXT
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![BU of 5txt by Molmil](/molmil-images/mine/5txt) | Structure of asymmetric apo/holo ALAS dimer from S. cerevisiae | Descriptor: | 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, 5-aminolevulinate synthase, mitochondrial, ... | Authors: | Brown, B.L, Grant, R.A, Kardon, J.R, Sauer, R.T, Baker, T.A. | Deposit date: | 2016-11-17 | Release date: | 2018-03-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme. Structure, 26, 2018
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5TXR
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![BU of 5txr by Molmil](/molmil-images/mine/5txr) | Structure of ALAS from S. cerevisiae non-covalently bound to PLP cofactor | Descriptor: | 5-aminolevulinate synthase, mitochondrial, FORMIC ACID, ... | Authors: | Brown, B.L, Grant, R.A, Kardon, J.R, Sauer, R.T, Baker, T.A. | Deposit date: | 2016-11-17 | Release date: | 2018-03-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme. Structure, 26, 2018
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4YJX
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![BU of 4yjx by Molmil](/molmil-images/mine/4yjx) | The structure of Agrobacterium tumefaciens ClpS2 bound to L-phenylalaninamide | Descriptor: | ATP-dependent Clp protease adapter protein ClpS 2, PHENYLALANINE AMIDE, SULFATE ION | Authors: | Stein, B, Grant, R.A, Sauer, R.T, Baker, T.A. | Deposit date: | 2015-03-03 | Release date: | 2016-01-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.547 Å) | Cite: | Structural Basis of an N-Degron Adaptor with More Stringent Specificity. Structure, 24, 2016
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7M1M
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![BU of 7m1m by Molmil](/molmil-images/mine/7m1m) | Crystal structure of Pseudomonas aeruginosa ClpP1 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ATP-dependent Clp protease proteolytic subunit | Authors: | Mawla, G.D, Grant, R.A, Baker, T.A, Sauer, R.T. | Deposit date: | 2021-03-13 | Release date: | 2021-03-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | ClpP1P2 peptidase activity promotes biofilm formation in Pseudomonas aeruginosa. Mol.Microbiol., 115, 2021
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7M1L
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![BU of 7m1l by Molmil](/molmil-images/mine/7m1l) | Crystal structure of Pseudomonas aeruginosa ClpP2 | Descriptor: | ATP-dependent Clp protease proteolytic subunit, PHOSPHATE ION | Authors: | Hall, B.M, Grant, R.A, Baker, T.A, Sauer, R.T. | Deposit date: | 2021-03-13 | Release date: | 2021-03-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | ClpP1P2 peptidase activity promotes biofilm formation in Pseudomonas aeruginosa. Mol.Microbiol., 115, 2021
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6WR2
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![BU of 6wr2 by Molmil](/molmil-images/mine/6wr2) | |
6WRF
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![BU of 6wrf by Molmil](/molmil-images/mine/6wrf) | ClpX-ClpP complex bound to GFP-ssrA, recognition complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, ... | Authors: | Fei, X, Sauer, R.T. | Deposit date: | 2020-04-29 | Release date: | 2020-11-04 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates. Elife, 9, 2020
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6WSG
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![BU of 6wsg by Molmil](/molmil-images/mine/6wsg) | ClpX-ClpP complex bound to ssrA-tagged GFP, intermediate complex | Descriptor: | ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, Green fluorescent protein, ... | Authors: | Fei, X, Sauer, R.T. | Deposit date: | 2020-04-30 | Release date: | 2020-11-04 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates. Elife, 9, 2020
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6PXL
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![BU of 6pxl by Molmil](/molmil-images/mine/6pxl) | 3.74 Angstroms resolution structure of HlsU with an axial-channel plug | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent protease ATPase subunit HslU, MAGNESIUM ION, ... | Authors: | Baytshtok, V, Grant, R.A, Sauer, R.T. | Deposit date: | 2019-07-26 | Release date: | 2020-07-29 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.741 Å) | Cite: | Heat activates the AAA+ HslUV protease by melting an axial autoinhibitory plug. Cell Rep, 34, 2021
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6PXK
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![BU of 6pxk by Molmil](/molmil-images/mine/6pxk) | 3.65 Angstroms resolution structure of HslU with an axial-channel plug | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent protease ATPase subunit HslU, SULFATE ION, ... | Authors: | Baytshtok, V, Grant, R.A, Sauer, R.T. | Deposit date: | 2019-07-26 | Release date: | 2020-07-29 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.647 Å) | Cite: | Heat activates the AAA+ HslUV protease by melting an axial autoinhibitory plug. Cell Rep, 34, 2021
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3LH1
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![BU of 3lh1 by Molmil](/molmil-images/mine/3lh1) | Q191A mutant of the DegS-deltaPDZ | Descriptor: | Protease degS | Authors: | Sohn, J, Grant, R.A, Sauer, R.T. | Deposit date: | 2010-01-21 | Release date: | 2010-08-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.507 Å) | Cite: | Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. J.Biol.Chem., 285, 2010
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3LGU
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![BU of 3lgu by Molmil](/molmil-images/mine/3lgu) | Y162A mutant of the DegS-deltaPDZ protease | Descriptor: | Protease degS | Authors: | Sohn, J, Grant, R.A, Sauer, R.T. | Deposit date: | 2010-01-21 | Release date: | 2010-08-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. J.Biol.Chem., 285, 2010
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3LGY
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![BU of 3lgy by Molmil](/molmil-images/mine/3lgy) | R178A mutant of the DegS-deltaPDZ protease | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Protease degS | Authors: | Sohn, J, Grant, R.A, Sauer, R.T. | Deposit date: | 2010-01-21 | Release date: | 2010-08-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. J.Biol.Chem., 285, 2010
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3LGI
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![BU of 3lgi by Molmil](/molmil-images/mine/3lgi) | |
3LGT
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![BU of 3lgt by Molmil](/molmil-images/mine/3lgt) | |
3LH3
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![BU of 3lh3 by Molmil](/molmil-images/mine/3lh3) | DFP modified DegS delta PDZ | Descriptor: | Protease degS | Authors: | Sohn, J, Grant, R.A, Sauer, R.T. | Deposit date: | 2010-01-21 | Release date: | 2010-08-25 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. J.Biol.Chem., 285, 2010
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3LGV
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![BU of 3lgv by Molmil](/molmil-images/mine/3lgv) | H198P mutant of the DegS-deltaPDZ protease | Descriptor: | Protease degS | Authors: | Sohn, J, Grant, R.A, Sauer, R.T. | Deposit date: | 2010-01-21 | Release date: | 2010-08-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.734 Å) | Cite: | Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. J.Biol.Chem., 285, 2010
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3LGW
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![BU of 3lgw by Molmil](/molmil-images/mine/3lgw) | |