6TX8
 
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6TX6
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6TXX
 | | CRYSTAL STRUCTURE OF HUMAN FKBP51 FK1 DOMAIN A19T MUTANT IN COMPLEX WITH SAFit2 | | Descriptor: | (1R)-3-(3,4-dimethoxyphenyl)-1-{3-[2-(morpholin-4-yl)ethoxy]phenyl}propyl (2S)-1-[(2S)-2-[(1S)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Fiegen, D, Draxler, S.W. | | Deposit date: | 2020-01-14 | | Release date: | 2020-05-27 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Hybrid Screening Approach for Very Small Fragments: X-ray and Computational Screening on FKBP51.
J.Med.Chem., 63, 2020
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4YHL
 | | Reversal Agent for Dabigatran | | Descriptor: | aDabi-Fab2b heavy chain, aDabi-Fab2b light chain | | Authors: | Schiele, F, Nar, H. | | Deposit date: | 2015-02-27 | | Release date: | 2016-01-13 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Structure-guided residence time optimization of a dabigatran reversal agent.
Mabs, 7, 2015
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4YHI
 | | Reversal Agent for Dabigatran | | Descriptor: | N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine, aDabi-Fab2a heavy chain, aDabi-Fab2a light chain | | Authors: | Schiele, F, Nar, H. | | Deposit date: | 2015-02-27 | | Release date: | 2016-01-13 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure-guided residence time optimization of a dabigatran reversal agent.
Mabs, 7, 2015
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4YHM
 | | Reversal Agent for Dabigatran | | Descriptor: | N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine, aDabi-Fab2b heavy chain, aDabi-Fab2b light chain | | Authors: | Schiele, F, Nar, H. | | Deposit date: | 2015-02-27 | | Release date: | 2016-01-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Structure-guided residence time optimization of a dabigatran reversal agent.
Mabs, 7, 2015
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4YGV
 | | Reversal Agent for Dabigatran | | Descriptor: | GLYCEROL, aDabi-Fab2a heavy chain, aDabi-Fab2a light chain | | Authors: | Schiele, F, Nar, H. | | Deposit date: | 2015-02-26 | | Release date: | 2015-06-17 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Structure-guided residence time optimization of a dabigatran reversal agent.
Mabs, 7, 2015
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4YHK
 | | Reversal Agent for Dabigatran | | Descriptor: | GLYCEROL, N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine, aDabi-Fab2a heavy chain, ... | | Authors: | Schiele, F, Nar, H. | | Deposit date: | 2015-02-27 | | Release date: | 2016-01-13 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Structure-guided residence time optimization of a dabigatran reversal agent.
Mabs, 7, 2015
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4YHN
 | | Dabigatran Reversal Agent | | Descriptor: | aDabi-Fab3 heavy chain, aDabi-Fab3 light chain | | Authors: | Schiele, F, Nar, H. | | Deposit date: | 2015-02-27 | | Release date: | 2016-02-10 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Structure-guided residence time optimization of a dabigatran reversal agent.
Mabs, 7, 2015
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4YHO
 | | Reversal Agent for Dabigatran | | Descriptor: | N-[(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alanine, aDabi-Fab3 heavy chain, aDabi-Fab3 light chain | | Authors: | Schiele, F, Nar, H. | | Deposit date: | 2015-02-27 | | Release date: | 2016-01-13 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Structure-guided residence time optimization of a dabigatran reversal agent.
Mabs, 7, 2015
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2WFJ
 | | Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A. | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, CYCLOSPORIN A, ... | | Authors: | Stegmann, C.M, Sheldrick, G.M, Wahl, M.C. | | Deposit date: | 2009-04-06 | | Release date: | 2009-06-16 | | Last modified: | 2019-05-22 | | Method: | X-RAY DIFFRACTION (0.75 Å) | | Cite: | The Thermodynamic Influence of Trapped Water Molecules on a Protein-Ligand Interaction.
Angew.Chem.Int.Ed.Engl., 48, 2009
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2WFI
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4EOW
 | | Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007 | | Descriptor: | MB007 IgG1 Fab fragment light chain, MB007 human IgG1 Fab fragment heavy chain | | Authors: | Blech, M. | | Deposit date: | 2012-04-16 | | Release date: | 2012-08-22 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Molecular structure of human GM-CSF in complex with a disease-associated anti-human GM-CSF autoantibody and its potential biological implications.
Biochem.J., 447, 2012
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