4EOW

Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007

Summary for 4EOW

• Entry DOI: 10.2210/pdb4eow/pdb
• Descriptor: MB007 human IgG1 Fab fragment heavy chain, MB007 IgG1 Fab fragment light chain (3 entities in total)
• Functional Keywords: immunsystem, alpha-helical stretch in cdr3-h, protein-docking, immunoglobulin igg1 (lambda), autoantibody causing pap, gm-csf, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted : P0DOY2
• Total number of polymer chains: 2
• Total formula weight: 47541.88

Authors

Blech, M. (deposition date: 2012-04-16, release date: 2012-08-22, Last modification date: 2024-03-06)

• Primary citation: Blech, M.,Seeliger, D.,Kistler, B.,Bauer, M.M.,Hafner, M.,Horer, S.,Zeeb, M.,Nar, H.,Park, J.E.; Molecular structure of human GM-CSF in complex with a disease-associated anti-human GM-CSF autoantibody and its potential biological implications.; Biochem.J., 447:205-215, 2012; PubMed: 22839360; DOI: 10.1042/BJ20120884

Experimental method

X-RAY DIFFRACTION (1.97 Å)