4EOW

Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	MB007 human IgG1 Fab fragment heavy chain	polymer	228	24574.6	1	UniProt (S6B291) Pfam (PF07654) UniProt (by SIFTS) (P01857)	Homo sapiens (human)
2	B (L)	MB007 IgG1 Fab fragment light chain	polymer	216	22967.3	1	UniProt (P0DOY2) Pfam (PF07654)	Homo sapiens (human)	Ig lambda chain C region Kern,Ig lambda chain C region NIG-64,Ig lambda chain C region SH,Ig lambda chain C region X,Ig lambda-2 chain C region
3	C, D (H, L)	water	water		18.0	316	Chemie (HOH)

Sequence modifications

H: 1 - 127 (PDB: 4EOW)
H: 128 - 228 (UniProt: S6B291)
L: 1 - 111 (PDB: 4EOW)
L: 112 - 216 (UniProt: P0DOY2)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47541.9
All*	Total formula weight	47541.9

*Water molecules are not included.