4EOW
Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007
Summary for 4EOW
Entry DOI | 10.2210/pdb4eow/pdb |
Descriptor | MB007 human IgG1 Fab fragment heavy chain, MB007 IgG1 Fab fragment light chain (3 entities in total) |
Functional Keywords | immunsystem, alpha-helical stretch in cdr3-h, protein-docking, immunoglobulin igg1 (lambda), autoantibody causing pap, gm-csf, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted : P0DOY2 |
Total number of polymer chains | 2 |
Total formula weight | 47541.88 |
Authors | Blech, M. (deposition date: 2012-04-16, release date: 2012-08-22, Last modification date: 2024-03-06) |
Primary citation | Blech, M.,Seeliger, D.,Kistler, B.,Bauer, M.M.,Hafner, M.,Horer, S.,Zeeb, M.,Nar, H.,Park, J.E. Molecular structure of human GM-CSF in complex with a disease-associated anti-human GM-CSF autoantibody and its potential biological implications. Biochem.J., 447:205-215, 2012 Cited by PubMed: 22839360DOI: 10.1042/BJ20120884 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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