4YHL

Reversal Agent for Dabigatran

Summary for 4YHL

• Entry DOI: 10.2210/pdb4yhl/pdb
• Descriptor: aDabi-Fab2b heavy chain, aDabi-Fab2b light chain (3 entities in total)
• Functional Keywords: antibody, dabigatran, pradaxa, antidote, reversal agent, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 47732.30

Authors

Schiele, F.,Nar, H. (deposition date: 2015-02-27, release date: 2016-01-13, Last modification date: 2024-01-10)

• Primary citation: Schiele, F.,van Ryn, J.,Litzenburger, T.,Ritter, M.,Seeliger, D.,Nar, H.; Structure-guided residence time optimization of a dabigatran reversal agent.; Mabs, 7:871-880, 2015; PubMed: 26047352; DOI: 10.1080/19420862.2015.1057364

Experimental method

X-RAY DIFFRACTION (2.09 Å)