1MNA
| Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.0 | Descriptor: | polyketide synthase IV | Authors: | Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M. | Deposit date: | 2002-09-05 | Release date: | 2003-02-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases Biochemistry, 41, 2002
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1MNQ
| Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.4 | Descriptor: | polyketide synthase IV | Authors: | Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M. | Deposit date: | 2002-09-05 | Release date: | 2003-02-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases Biochemistry, 41, 2002
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1MO2
| Thioesterase Domain from 6-Deoxyerythronolide Synthase (DEBS TE), pH 8.5 | Descriptor: | Erythronolide synthase, modules 5 and 6 | Authors: | Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M. | Deposit date: | 2002-09-05 | Release date: | 2003-02-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases Biochemistry, 41, 2002
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2JU2
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1KEZ
| Crystal Structure of the Macrocycle-forming Thioesterase Domain of Erythromycin Polyketide Synthase (DEBS TE) | Descriptor: | ERYTHRONOLIDE SYNTHASE | Authors: | Tsai, S.-C, Miercke, L.J.W, Krucinski, J, Gokhale, R, Chen, J.C.-H, Foster, P.G, Cane, D.E, Khosla, C, Stroud, R.M. | Deposit date: | 2001-11-19 | Release date: | 2002-01-09 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel. Proc.Natl.Acad.Sci.USA, 98, 2001
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2JU1
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1XNY
| Biotin and propionyl-CoA bound to Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB) | Descriptor: | BIOTIN, propionyl Coenzyme A, propionyl-CoA carboxylase complex B subunit | Authors: | Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C. | Deposit date: | 2004-10-05 | Release date: | 2004-11-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity Biochemistry, 43, 2004
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1XNW
| Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #2, mutant D422I | Descriptor: | propionyl-CoA carboxylase complex B subunit | Authors: | Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C. | Deposit date: | 2004-10-05 | Release date: | 2004-11-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity Biochemistry, 43, 2004
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1XNV
| Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #1 | Descriptor: | propionyl-CoA carboxylase complex B subunit | Authors: | Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C. | Deposit date: | 2004-10-05 | Release date: | 2004-11-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity Biochemistry, 43, 2004
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1XO6
| Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #3 | Descriptor: | propionyl-CoA carboxylase complex B subunit | Authors: | Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C. | Deposit date: | 2004-10-05 | Release date: | 2004-11-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity Biochemistry, 43, 2004
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7M7E
| 6-Deoxyerythronolide B synthase (DEBS) hybrid module (M3/1) in complex with antibody fragment 1B2 | Descriptor: | 1B2 (heavy chain), 1B2 (light chain), 6-deoxyerythronolide-B synthase EryA2, ... | Authors: | Cogan, D.P, Zhang, K, Chiu, W, Khosla, C. | Deposit date: | 2021-03-28 | Release date: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science, 374, 2021
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7M7G
| 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 2 | Descriptor: | 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ... | Authors: | Cogan, D.P, Zhang, K, Chiu, W, Khosla, C. | Deposit date: | 2021-03-28 | Release date: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science, 374, 2021
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7M7H
| 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1' | Descriptor: | 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ... | Authors: | Cogan, D.P, Zhang, K, Chiu, W, Khosla, C. | Deposit date: | 2021-03-28 | Release date: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science, 374, 2021
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7M7I
| 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2 (TE-free) | Descriptor: | 1B2 (heavy chain), 1B2 (light chain), EryAI, ... | Authors: | Cogan, D.P, Zhang, K, Chiu, W, Khosla, C. | Deposit date: | 2021-03-28 | Release date: | 2021-11-17 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science, 374, 2021
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7M7J
| 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: "turnstile closed" state (TE-free) | Descriptor: | 1B2 (heavy chain), 1B2 (light chain), EryAI | Authors: | Cogan, D.P, Zhang, K, Chiu, W, Khosla, C. | Deposit date: | 2021-03-28 | Release date: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science, 374, 2021
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7M7F
| 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1 | Descriptor: | 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ... | Authors: | Cogan, D.P, Zhang, K, Chiu, W, Khosla, C. | Deposit date: | 2021-03-28 | Release date: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science, 374, 2021
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6APF
| Trans-acting transferase from Disorazole synthase complexed with Citrate. | Descriptor: | CITRIC ACID, DisD protein, GLYCEROL, ... | Authors: | Mathews, I.I, Lyubimov, A, Soltis, M, Khosla, C, Cohen, A, Robbins, T. | Deposit date: | 2017-08-17 | Release date: | 2018-04-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography. Biochemistry, 56, 2017
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6APG
| Trans-acting transferase from Disorazole synthase with malonate | Descriptor: | CALCIUM ION, DisD protein, GLYCEROL, ... | Authors: | Mathews, I.I, Lyubimov, A.Y, Soltis, S.M, Khosla, C, Robbins, T, Cohen, A.E. | Deposit date: | 2017-08-17 | Release date: | 2018-04-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography. Biochemistry, 56, 2017
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6APK
| Trans-acting transferase from Disorazole synthase solved by serial femtosecond XFEL crystallography | Descriptor: | DisD protein | Authors: | Lyubimov, A.Y, Mathews, I.I, Uervivojnangkoorn, M, Khosla, C, Soltis, S.M, Cohen, A.E. | Deposit date: | 2017-08-17 | Release date: | 2018-04-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography. Biochemistry, 56, 2017
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6C9U
| Crystal structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase in complex with antibody fragment (Fab) | Descriptor: | 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, Heavy chain of Fab 1B2, ... | Authors: | Deis, L.N, Li, X, Mathews, I.I, Khosla, C. | Deposit date: | 2018-01-28 | Release date: | 2018-05-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module. J. Am. Chem. Soc., 140, 2018
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6RIW
| PfaC Keto synthase-Chain length factor | Descriptor: | MAGNESIUM ION, ORF10 | Authors: | Santin, O, Moncalian, G. | Deposit date: | 2019-04-25 | Release date: | 2020-08-26 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure and Mechanism of the Ketosynthase-Chain Length Factor Didomain from a Prototypical Polyunsaturated Fatty Acid Synthase. Biochemistry, 59, 2020
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3SJU
| Hedamycin Polyketide Ketoreductase bound to NADPH | Descriptor: | Keto reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Javidpour, P, Tsai, S.-C. | Deposit date: | 2011-06-21 | Release date: | 2011-09-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase (HedKR): Molecular Basis of Stereo- and Regiospecificities. Biochemistry, 50, 2011
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6APM
| Hen egg-white lysozyme (WT), solved with serial millisecond crystallography using synchrotron radiation | Descriptor: | Lysozyme C, SODIUM ION | Authors: | Lyubimov, A.Y, Mathews, I.I, Uervivojnangkoorn, M, Soltis, S.M, Cohen, A.E. | Deposit date: | 2017-08-17 | Release date: | 2018-04-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography. Biochemistry, 56, 2017
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