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5LMC
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BU of 5lmc by Molmil
Oxidized flavodiiron core of Escherichia coli flavorubredoxin, including the Fe-4SG atoms from its rubredoxin domain
Descriptor: ACETIC ACID, Anaerobic nitric oxide reductase flavorubredoxin, CACODYLATE ION, ...
Authors:Romao, C.V, Borges, P.T, Vicente, J.B, Carrondo, M.A, Teixeira, M, Frazao, C.
Deposit date:2016-07-29
Release date:2016-10-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of Escherichia coli Flavodiiron Nitric Oxide Reductase.
J.Mol.Biol., 428, 2016
5LLD
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BU of 5lld by Molmil
Flavodiiron core of Escherichia coli flavorubredoxin in the reduced form.
Descriptor: Anaerobic nitric oxide reductase flavorubredoxin, FE (III) ION, FLAVIN MONONUCLEOTIDE, ...
Authors:Romao, C.V, Borges, P.T, Vicente, J.B, Carrondo, M.A, Teixeira, M, Frazao, C.
Deposit date:2016-07-27
Release date:2016-10-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.651 Å)
Cite:Structure of Escherichia coli Flavodiiron Nitric Oxide Reductase.
J.Mol.Biol., 428, 2016
7ZJQ
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BU of 7zjq by Molmil
Human TEAD3 in complex with 1-Cyclopentyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid
Descriptor: 1-cyclopentylpyrazolo[3,4-b]pyridine-5-carboxylic acid, Transcriptional enhancer factor TEF-5
Authors:Musil, D, Sousa, C.M.
Deposit date:2022-04-11
Release date:2022-07-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.095 Å)
Cite:Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106 .
J.Med.Chem., 65, 2022
8AU3
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BU of 8au3 by Molmil
c-MET Y1234E,Y1235E mutant in complex with Tepotinib
Descriptor: 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile, DI(HYDROXYETHYL)ETHER, Hepatocyte growth factor receptor, ...
Authors:Graedler, U, Lammens, A.
Deposit date:2022-08-25
Release date:2023-09-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding.
J.Biol.Chem., 299, 2023
8AW1
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BU of 8aw1 by Molmil
c-MET Y1235D mutant in complex with Tepotinib
Descriptor: 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile, Hepatocyte growth factor receptor
Authors:Graedler, U, Lammens, A.
Deposit date:2022-08-29
Release date:2023-09-06
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding.
J.Biol.Chem., 299, 2023
8AU5
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BU of 8au5 by Molmil
c-MET F1200I mutant in complex with Tepotinib
Descriptor: 1,2-ETHANEDIOL, 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile, CHLORIDE ION, ...
Authors:Graedler, U, Lammens, A.
Deposit date:2022-08-25
Release date:2023-09-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding.
J.Biol.Chem., 299, 2023
7ZDN
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BU of 7zdn by Molmil
Human Cyclophilin D in complex with fragment
Descriptor: (1~{R},9~{R},10~{S})-12-oxa-8-azatricyclo[7.3.1.0^{2,7}]trideca-2(7),3,5-trien-10-ol, Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Authors:Silva, D.O, Graedler, U, Bandeiras, T.M.
Deposit date:2022-03-29
Release date:2023-04-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Human Cyclophilin D in complex with fragment
To Be Published
7PMT
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BU of 7pmt by Molmil
Human Cyclophilin D in complex with N-[(5-ethyl-4-oxo-1,2,3,4,5,6- hexahydro-1,5-benzodiazocin-8-yl)methyl]-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide
Descriptor: DIMETHYL SULFOXIDE, Peptidyl-prolyl cis-trans isomerase F, mitochondrial, ...
Authors:Silva, D.O, Graedler, U, Bandeiras, T.M.
Deposit date:2021-09-02
Release date:2022-09-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (0.98 Å)
Cite:Human Cyclophilin D in complex with N-[(4-aminophenyl)methyl]-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide
To Be Published
7R2I
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BU of 7r2i by Molmil
Human Cyclophilin D in complex with fragment
Descriptor: DIMETHYL SULFOXIDE, PENTAETHYLENE GLYCOL, Peptidyl-prolyl cis-trans isomerase F, ...
Authors:Silva, D.O, Graedler, U, Bandeiras, T.M.
Deposit date:2022-02-04
Release date:2023-02-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Human Cyclophilin D in complex with fragment
To Be Published
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