8AW1

c-MET Y1235D mutant in complex with Tepotinib

Summary for 8AW1

• Entry DOI: 10.2210/pdb8aw1/pdb
• Descriptor: Hepatocyte growth factor receptor, 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile (3 entities in total)
• Functional Keywords: protein kinase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 68777.72

Authors

Graedler, U.,Lammens, A. (deposition date: 2022-08-29, release date: 2023-09-06, Last modification date: 2024-03-20)

• Primary citation: Gradler, U.,Schwarz, D.,Wegener, A.,Eichhorn, T.,Bandeiras, T.M.,Freitas, M.C.,Lammens, A.,Ganichkin, O.,Augustin, M.,Minguzzi, S.,Becker, F.,Bomke, J.; Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding.; J.Biol.Chem., 299:105328-105328, 2023; PubMed: 37806493; DOI: 10.1016/j.jbc.2023.105328

Experimental method

X-RAY DIFFRACTION (2.14 Å)