8AU3
c-MET Y1234E,Y1235E mutant in complex with Tepotinib
Summary for 8AU3
Entry DOI | 10.2210/pdb8au3/pdb |
Descriptor | Hepatocyte growth factor receptor, 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile, TETRAETHYLENE GLYCOL, ... (5 entities in total) |
Functional Keywords | protein kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 69038.00 |
Authors | Graedler, U.,Lammens, A. (deposition date: 2022-08-25, release date: 2023-09-06, Last modification date: 2023-11-22) |
Primary citation | Gradler, U.,Schwarz, D.,Wegener, A.,Eichhorn, T.,Bandeiras, T.M.,Freitas, M.C.,Lammens, A.,Ganichkin, O.,Augustin, M.,Minguzzi, S.,Becker, F.,Bomke, J. Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding. J.Biol.Chem., 299:105328-105328, 2023 Cited by PubMed: 37806493DOI: 10.1016/j.jbc.2023.105328 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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