8AU3

c-MET Y1234E,Y1235E mutant in complex with Tepotinib

Summary for 8AU3

Entry DOI	10.2210/pdb8au3/pdb
Descriptor	Hepatocyte growth factor receptor, 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile, TETRAETHYLENE GLYCOL, ... (5 entities in total)
Functional Keywords	protein kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	69038.00
Authors	Graedler, U.,Lammens, A. (deposition date: 2022-08-25, release date: 2023-09-06, Last modification date: 2023-11-22)
Primary citation	Gradler, U.,Schwarz, D.,Wegener, A.,Eichhorn, T.,Bandeiras, T.M.,Freitas, M.C.,Lammens, A.,Ganichkin, O.,Augustin, M.,Minguzzi, S.,Becker, F.,Bomke, J. Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding. J.Biol.Chem., 299:105328-105328, 2023 Cited by PubMed: 37806493 DOI: 10.1016/j.jbc.2023.105328 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.26 Å)

Structure validation