8AU3
c-MET Y1234E,Y1235E mutant in complex with Tepotinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Hepatocyte growth factor receptor | polymer | 299 | 33876.3 | 2 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
| 2 | C, D (A, B) | 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile | non-polymer | 492.6 | 2 | Chemie (3E8) | |||
| 3 | E (B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 4 | F (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
A, B: 1051 - 1349 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Glu 1234 | Tyr 1234 | engineered mutation |
| Glu 1235 | Tyr 1235 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67752.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1285.5 | |
| All* | Total formula weight | 69038.0 |
