5L24
 
 | | Structure of CNTnw N149L in the intermediate 2 state | | Descriptor: | 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Nucleoside permease | | Authors: | Hirschi, M, Johnson, Z.L, Lee, S.-Y. | | Deposit date: | 2016-07-31 | | Release date: | 2017-04-12 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (4.1 Å) | | Cite: | Visualizing multistep elevator-like transitions of a nucleoside transporter.
Nature, 545, 2017
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5L26
 | | Structure of CNTnw in an inward-facing substrate-bound state | | Descriptor: | 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Nucleoside permease, SODIUM ION, ... | | Authors: | Hirschi, M, Johnson, Z.L, Lee, S.-Y. | | Deposit date: | 2016-07-31 | | Release date: | 2017-04-12 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Visualizing multistep elevator-like transitions of a nucleoside transporter.
Nature, 545, 2017
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4PB2
 | | Structure of vcCNT-7C8C bound to 5-fluorouridine | | Descriptor: | 5-FLUOROURIDINE, DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, ... | | Authors: | Johnson, Z.L, Lee, S.-Y. | | Deposit date: | 2014-04-11 | | Release date: | 2014-08-13 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.302 Å) | | Cite: | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.
Elife, 3, 2014
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4PD7
 | | Structure of vcCNT bound to zebularine | | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, SODIUM ION, ... | | Authors: | Johnson, Z.L, Lee, S.-Y. | | Deposit date: | 2014-04-17 | | Release date: | 2014-08-13 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.909 Å) | | Cite: | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.
Elife, 3, 2014
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4PD6
 | | Crystal structure of vcCNT-7C8C bound to uridine | | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, SODIUM ION, ... | | Authors: | Johnson, Z.L, Lee, S.-Y. | | Deposit date: | 2014-04-17 | | Release date: | 2014-08-13 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.
Elife, 3, 2014
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4PD8
 | | Structure of vcCNT-7C8C bound to pyrrolo-cytidine | | Descriptor: | 6-methyl-3-(beta-D-ribofuranosyl)-3,7-dihydro-2H-pyrrolo[2,3-d]pyrimidin-2-one, DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, ... | | Authors: | Johnson, Z.L, Lee, S.-Y. | | Deposit date: | 2014-04-17 | | Release date: | 2014-08-13 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.
Elife, 3, 2014
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4PD5
 | | Crystal structure of vcCNT-7C8C bound to gemcitabine | | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, GEMCITABINE, NupC family protein, ... | | Authors: | Johnson, Z.L, Lee, S.-Y. | | Deposit date: | 2014-04-17 | | Release date: | 2014-08-13 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.906 Å) | | Cite: | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.
Elife, 3, 2014
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4PDA
 | | Structure of vcCNT-7C8C bound to cytidine | | Descriptor: | 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, ... | | Authors: | Johnson, Z.L, Lee, S.-Y. | | Deposit date: | 2014-04-17 | | Release date: | 2014-08-13 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.608 Å) | | Cite: | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.
Elife, 3, 2014
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4PB1
 | | Structure of vcCNT-7C8C bound to ribavirin | | Descriptor: | 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide, DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, ... | | Authors: | Johnson, Z.L, Lee, S.-Y. | | Deposit date: | 2014-04-11 | | Release date: | 2014-08-13 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.803 Å) | | Cite: | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.
Elife, 3, 2014
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4PD9
 | | Structure of vcCNT-7C8C bound to adenosine | | Descriptor: | ADENOSINE, DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, ... | | Authors: | Johnson, Z.L, Lee, S.-Y. | | Deposit date: | 2014-04-17 | | Release date: | 2014-08-13 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.096 Å) | | Cite: | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.
Elife, 3, 2014
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3QMX
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7LPE
 | | Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an open state, class 1 | | Descriptor: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | | Deposit date: | 2021-02-11 | | Release date: | 2021-07-28 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.72 Å) | | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin.
Nat.Struct.Mol.Biol., 28, 2021
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7LPA
 | | Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees Celsius | | Descriptor: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... | | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | | Deposit date: | 2021-02-11 | | Release date: | 2021-07-28 | | Method: | ELECTRON MICROSCOPY (3.37 Å) | | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin.
Nat.Struct.Mol.Biol., 28, 2021
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7LPB
 | | Cryo-EM structure of full-length TRPV1 with capsaicin at 25 degrees Celsius | | Descriptor: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... | | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | | Deposit date: | 2021-02-11 | | Release date: | 2021-07-28 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin.
Nat.Struct.Mol.Biol., 28, 2021
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7LPD
 | | Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an intermediate state, class 2 | | Descriptor: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | | Deposit date: | 2021-02-11 | | Release date: | 2021-07-28 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.55 Å) | | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin.
Nat.Struct.Mol.Biol., 28, 2021
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7LP9
 | | Cryo-EM structure of full-length TRPV1 at 4 degrees Celsius | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... | | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | | Deposit date: | 2021-02-11 | | Release date: | 2021-07-28 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.63 Å) | | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin.
Nat.Struct.Mol.Biol., 28, 2021
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7LPC
 | | Cryo-EM structure of full-length TRPV1 at 48 degrees Celsius | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... | | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | | Deposit date: | 2021-02-11 | | Release date: | 2021-07-28 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin.
Nat.Struct.Mol.Biol., 28, 2021
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6DT0
 | | Cryo-EM structure of a mitochondrial calcium uniporter | | Descriptor: | CALCIUM ION, Mitochondrial calcium uniporter | | Authors: | Yoo, J, Wu, M, Yin, Y, Herzik, M.A.J, Lander, G.C, Lee, S.-Y. | | Deposit date: | 2018-06-14 | | Release date: | 2018-07-11 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Cryo-EM structure of a mitochondrial calcium uniporter.
Science, 361, 2018
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6BW5
 | | Human GPT (DPAGT1) in complex with tunicamycin | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Tunicamycin, UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase | | Authors: | Yoo, J, Kuk, A.C.Y, Mashalidis, E.H, Lee, S.-Y. | | Deposit date: | 2017-12-14 | | Release date: | 2018-02-21 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.
Nat. Struct. Mol. Biol., 25, 2018
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6BPQ
 | | Structure of the cold- and menthol-sensing ion channel TRPM8 | | Descriptor: | Transient receptor potential cation channel subfamily M member 8 | | Authors: | Yin, Y, Wu, M, Zubcevic, L, Borschel, W.F, Lander, G.C, Lee, S.-Y. | | Deposit date: | 2017-11-25 | | Release date: | 2017-12-13 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structure of the cold- and menthol-sensing ion channel TRPM8.
Science, 359, 2018
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1OB0
 | | Kinetic stabilization of Bacillus licheniformis alpha-amylase through introduction of hydrophobic residues at the surface | | Descriptor: | ALPHA-AMYLASE, CALCIUM ION, SODIUM ION | | Authors: | Machius, M, Declerck, N, Huber, R, Wiegand, G. | | Deposit date: | 2003-01-21 | | Release date: | 2003-01-30 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Kinetic Stabilization of Bacillus Licheniformis Alpha-Amylase Through Introduction of Hydrophobic Residues at the Surface
J.Biol.Chem., 278, 2003
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6D73
 | | Cryo-EM structure of the zebrafish TRPM2 channel in the presence of Ca2+ | | Descriptor: | CALCIUM ION, Transient receptor potential cation channel, subfamily M | | Authors: | Yin, Y, Wu, M, Borschel, W.F, Lander, G.C, Lee, S.-Y. | | Deposit date: | 2018-04-23 | | Release date: | 2019-05-15 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
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6BW6
 | | Human GPT (DPAGT1) H129 variant in complex with tunicamycin | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Tunicamycin, UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase | | Authors: | Yoo, J, Kuk, A.C.Y, Mashalidis, E.H, Lee, S.-Y. | | Deposit date: | 2017-12-14 | | Release date: | 2018-02-21 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.
Nat. Struct. Mol. Biol., 25, 2018
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5U9W
 | | Structure of CNTnw N149L in the intermediate 3 state | | Descriptor: | 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Nucleoside permease | | Authors: | Hirschi, M, Johnson, Z.L, Lee, S.-Y. | | Deposit date: | 2016-12-18 | | Release date: | 2017-04-12 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.555 Å) | | Cite: | Visualizing multistep elevator-like transitions of a nucleoside transporter.
Nature, 545, 2017
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2X26
 | | Crystal structure of the periplasmic aliphatic sulphonate binding protein SsuA from Escherichia coli | | Descriptor: | GLYCEROL, PERIPLASMIC ALIPHATIC SULPHONATES-BINDING PROTEIN | | Authors: | Beale, J, Lee, S, Iwata, S, Beis, K. | | Deposit date: | 2010-01-11 | | Release date: | 2010-04-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structure of the Aliphatic Sulfonate-Binding Protein Ssua from Escherichia Coli
Acta Crystallogr.,Sect.F, 66, 2010
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