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4N1Z
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BU of 4n1z by Molmil
Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1222
Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Liu, Y.L, Xia, Y, Zhang, Y, Verma, I, Oldfield, E.
Deposit date:2013-10-04
Release date:2014-12-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin.
Sci Transl Med, 6, 2014
5ZZ3
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BU of 5zz3 by Molmil
Crystal structure of intracellular B30.2 domain of BTN3A3
Descriptor: Butyrophilin, subfamily 3, member A3 isoform b variant
Authors:Yang, Y.Y, Li, X, Liu, W.D, Chen, C.C, Guo, R.T, Zhang, Y.H.
Deposit date:2018-05-30
Release date:2019-04-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation.
Immunity, 50, 2019
5ZXK
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BU of 5zxk by Molmil
Crystal structure of intracellular B30.2 domain of BTN3A1 in complex with HMBPP
Descriptor: (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, Butyrophilin subfamily 3 member A1
Authors:Yang, Y.Y, Liu, W.D, Chen, C.C, Guo, R.T, Zhang, Y.H.
Deposit date:2018-05-21
Release date:2019-04-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation.
Immunity, 50, 2019
6IEV
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BU of 6iev by Molmil
Crystal structure of a designed protein
Descriptor: Designed protein
Authors:Han, M, Liao, S, Chen, Q, Liu, H.
Deposit date:2018-09-17
Release date:2019-09-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Selection and analyses of variants of a designed protein suggest importance of hydrophobicity of partially buried sidechains for protein stability at high temperatures.
Protein Sci., 28, 2019
5ZBG
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BU of 5zbg by Molmil
Cryo-EM structure of human TRPC3 at 4.36A resolution
Descriptor: Short transient receptor potential channel 3
Authors:Chen, L, Tang, Q, Guo, W.
Deposit date:2018-02-11
Release date:2018-05-09
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.36 Å)
Cite:Structure of the receptor-activated human TRPC6 and TRPC3 ion channels
Cell Res., 28, 2018
5YX9
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BU of 5yx9 by Molmil
Cryo-EM structure of human TRPC6 at 3.8A resolution
Descriptor: Short transient receptor potential channel 6
Authors:Chen, L, Tang, Q, Guo, W.
Deposit date:2017-12-02
Release date:2018-05-23
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of the receptor-activated human TRPC6 and TRPC3 ion channels.
Cell Res., 28, 2018
7E1H
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BU of 7e1h by Molmil
crystal structure of RD-BEF
Descriptor: BERYLLIUM TRIFLUORIDE ION, DNA-binding response regulator, MAGNESIUM ION
Authors:Hong, S, Zhang, X, Zhang, P.
Deposit date:2021-02-01
Release date:2022-02-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.805 Å)
Cite:Structural basis of phosphorylation-induced activation of the response regulator VbrR.
Acta Biochim.Biophys.Sin., 2023
7E1B
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BU of 7e1b by Molmil
Crystal structure of VbrR-DNA complex
Descriptor: DNA (26-MER), DNA-binding response regulator
Authors:Hong, S, Zhang, X, Zhang, P.
Deposit date:2021-02-01
Release date:2022-02-09
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (4.587 Å)
Cite:Structural basis of phosphorylation-induced activation of the response regulator VbrR.
Acta Biochim.Biophys.Sin., 2023
7EF1
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BU of 7ef1 by Molmil
crystal structure of maize SHH2 SAWADEE domain in complex with and H3K9me1 peptide
Descriptor: HB transcription factor, Histone H3.2, ZINC ION
Authors:Wang, Y, Du, J.
Deposit date:2021-03-20
Release date:2021-06-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2.
J Integr Plant Biol, 63, 2021
7EEZ
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BU of 7eez by Molmil
crystal structure of maize SHH2 SAWADEE domain
Descriptor: HB transcription factor, ZINC ION
Authors:Wang, Y, Du, J.
Deposit date:2021-03-20
Release date:2021-06-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.902 Å)
Cite:Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2.
J Integr Plant Biol, 63, 2021
7EF2
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BU of 7ef2 by Molmil
Crystal structure of maize SHH2 SAWADEE domain in complex with an H3K9me3 peptide
Descriptor: HB transcription factor, Histone H3.2, ZINC ION
Authors:Wang, Y, Du, J.
Deposit date:2021-03-20
Release date:2021-06-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2.
J Integr Plant Biol, 63, 2021
7EF3
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BU of 7ef3 by Molmil
crystal structure of maize SHH2 SAWADEE domain in complex with H3K9me2 peptide
Descriptor: HB transcription factor, Histone H3.2, ZINC ION
Authors:Wang, Y, Du, J.
Deposit date:2021-03-20
Release date:2021-06-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2.
J Integr Plant Biol, 63, 2021
7EF0
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BU of 7ef0 by Molmil
Crystal structure of maize SHH2 SAWADEE domain in complex with an H3K9M peptide
Descriptor: HB transcription factor, Histone H3.2, ZINC ION
Authors:Wang, Y, Du, J.
Deposit date:2021-03-20
Release date:2021-06-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2.
J Integr Plant Biol, 63, 2021
8J0F
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BU of 8j0f by Molmil
GK tetramer with adjacent hooks at reaction state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Delta-1-pyrroline-5-carboxylate synthase B, GAMMA-GLUTAMYL PHOSPHATE, ...
Authors:Zhang, T, Guo, C.J, Liu, J.L.
Deposit date:2023-04-10
Release date:2024-04-17
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Dynamic Arabidopsis P5CS filament facilitates substrate channelling.
Nat.Plants, 10, 2024
7VLQ
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BU of 7vlq by Molmil
Crystal structure of SARS-Cov-2 main protease in complex with PF07321332 in spacegroup P212121
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase
Authors:Zhou, X.L, Zhong, F.L, Lin, C, Zhang, J, Li, J.
Deposit date:2021-10-05
Release date:2022-04-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.939106 Å)
Cite:Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332.
J.Virol., 96, 2022
7VTC
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BU of 7vtc by Molmil
Crystal structure of MERS main protease in complex with PF07321332
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase
Authors:Lin, C, Zhong, F.L, Zhou, X.L, Zhang, J, Li, J.
Deposit date:2021-10-28
Release date:2022-03-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.53865623 Å)
Cite:Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332.
J.Virol., 96, 2022
7VLO
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BU of 7vlo by Molmil
Crystal structure of SARS coronavirus main protease in complex with PF07321332
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase
Authors:Lin, C, Zhong, F.L, Zhou, X.L, Li, J, Zhang, J.
Deposit date:2021-10-05
Release date:2022-04-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.0227 Å)
Cite:Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332.
J.Virol., 96, 2022
7VLP
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BU of 7vlp by Molmil
Crystal structure of SARS-Cov-2 main protease in complex with PF07321332 in spacegroup P1211
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, Replicase polyprotein 1a
Authors:Zhou, X.L, Zhong, F.L, Lin, C, Li, J, Zhang, J.
Deposit date:2021-10-05
Release date:2022-04-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.50251937 Å)
Cite:Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332.
J.Virol., 96, 2022
7JG3
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BU of 7jg3 by Molmil
Human GAR transformylase in complex with GAR substrate and AGF103 inhibitor
Descriptor: GLYCINAMIDE RIBONUCLEOTIDE, N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]furan-2-carbonyl}-L-glutamic acid, SODIUM ION, ...
Authors:Wong-Roushar, J, Dann III, C.E.
Deposit date:2020-07-18
Release date:2021-03-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.091 Å)
Cite:Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors
Bioorg.Med.Chem., 37, 2021
7JG4
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BU of 7jg4 by Molmil
Human GAR transformylase in complex with GAR substrate and AGF131 inhibitor
Descriptor: GLYCINAMIDE RIBONUCLEOTIDE, N-(5-{3-[(1S,7R,8R,9S)-4-amino-2-oxo-7lambda~4~-thia-3,5-diazatetracyclo[4.3.0.0~1,7~.0~7,9~]nona-3,5-dien-8-yl]propyl}thiophene-2-carbonyl)-L-glutamic acid, SODIUM ION, ...
Authors:Wong-Roushar, J, Dann III, C.E.
Deposit date:2020-07-18
Release date:2021-03-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.455 Å)
Cite:Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors
Bioorg.Med.Chem., 37, 2021
7JG0
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BU of 7jg0 by Molmil
Human GAR transformylase in complex with GAR substrate and AGF102 inhibitor
Descriptor: GLYCINAMIDE RIBONUCLEOTIDE, N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]thiophene-2-carbonyl}-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3
Authors:Wong-Roushar, J, Dann III, C.E.
Deposit date:2020-07-18
Release date:2021-03-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.984 Å)
Cite:Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors
Bioorg.Med.Chem., 37, 2021
7E1F
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BU of 7e1f by Molmil
Native-DBD
Descriptor: DNA-binding response regulator
Authors:Hong, S, Zhang, P.
Deposit date:2021-02-01
Release date:2022-02-09
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.447 Å)
Cite:Structural basis of phosphorylation-induced activation of the response regulator VbrR.
Acta Biochim.Biophys.Sin., 2023
7E1D
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BU of 7e1d by Molmil
Se-DBD
Descriptor: DNA-binding response regulator
Authors:Hong, S, Zhang, P.
Deposit date:2021-02-01
Release date:2022-02-09
Last modified:2023-02-22
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Structural basis of phosphorylation-induced activation of the response regulator VbrR.
Acta Biochim.Biophys.Sin., 2023
7XRY
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BU of 7xry by Molmil
Crystal structure of MERS main protease in complex with inhibitor YH-53
Descriptor: N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methoxy-1H-indole-2-carboxamide, ORF1a
Authors:Lin, C, Zhong, F.L, Zhou, X.L, Li, J, Zhang, J.
Deposit date:2022-05-12
Release date:2022-12-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor.
Viruses, 14, 2022
7XRS
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BU of 7xrs by Molmil
Crystal structure of SARS-Cov-2 main protease in complex with inhibitor YH-53
Descriptor: N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methoxy-1H-indole-2-carboxamide, Replicase polyprotein 1a
Authors:Zhou, X.L, Zhong, F.L, Lin, C, Zeng, P, Zhang, J, Li, J.
Deposit date:2022-05-11
Release date:2022-12-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor.
Viruses, 14, 2022

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