2HFP
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![BU of 2hfp by Molmil](/molmil-images/mine/2hfp) | Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands | Descriptor: | 3-(4-METHOXYPHENYL)-N-(PHENYLSULFONYL)-1-[3-(TRIFLUOROMETHYL)BENZYL]-1H-INDOLE-2-CARBOXAMIDE, Peroxisome proliferator-activated receptor gamma, SRC Peptide Fragment | Authors: | Pokross, M.E, Evdokimov, A.G, Walter, R.L, Mekel, M.J, Hopkins, C.R. | Deposit date: | 2006-06-25 | Release date: | 2006-09-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis. Bioorg.Med.Chem.Lett., 16, 2006
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2JYF
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3S34
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![BU of 3s34 by Molmil](/molmil-images/mine/3s34) | Structure of the 1121B Fab fragment | Descriptor: | 1121B Fab heavy chain, 1121B Fab light chain, PHOSPHATE ION | Authors: | Franklin, M.C. | Deposit date: | 2011-05-17 | Release date: | 2011-08-24 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Structural Basis for the Function of Two Anti-VEGF Receptor 2 Antibodies. Structure, 19, 2011
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6NWK
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![BU of 6nwk by Molmil](/molmil-images/mine/6nwk) | |
8JBJ
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![BU of 8jbj by Molmil](/molmil-images/mine/8jbj) | Crystal structure of anti-PVRIG Fab | Descriptor: | antibody heavy chain, antibody light chain | Authors: | Sun, J, Li, X.L, Song, J. | Deposit date: | 2023-05-09 | Release date: | 2023-06-21 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Identification and characterization of an unexpected isomerization motif in CDRH2 that affects antibody activity. Mabs, 15, 2023
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8J9Z
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6BTM
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![BU of 6btm by Molmil](/molmil-images/mine/6btm) | Structure of Alternative Complex III from Flavobacterium johnsoniae (Wild Type) | Descriptor: | (2S)-3-hydroxypropane-1,2-diyl ditetradecanoate, Alternative Complex III subunit A, Alternative Complex III subunit B, ... | Authors: | Sun, C, Benlekbir, S, Venkatakrishnan, P, Yuhang, W, Tajkhorshid, E, Rubinstein, J.L, Gennis, R.B. | Deposit date: | 2017-12-07 | Release date: | 2018-05-09 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of the alternative complex III in a supercomplex with cytochrome oxidase. Nature, 557, 2018
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8J9Y
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3WYI
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![BU of 3wyi by Molmil](/molmil-images/mine/3wyi) | Structure of S. aureus undecaprenyl diphosphate synthase | Descriptor: | Isoprenyl transferase, MAGNESIUM ION | Authors: | Gao, J, Ko, T.P, Huang, C.H, Oldfield, E, Guo, R.T. | Deposit date: | 2014-08-29 | Release date: | 2015-02-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Antibacterial drug leads: DNA and enzyme multitargeting. J.Med.Chem., 58, 2015
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3WYJ
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![BU of 3wyj by Molmil](/molmil-images/mine/3wyj) | Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-789 | Descriptor: | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific), [1-oxidanyl-2-[3-[3-[[3-[[3-[3-(2-oxidanyl-2,2-diphosphono-ethyl)phenyl]phenyl]sulfamoyl]phenyl]sulfonylamino]phenyl]phenyl]-1-phosphono-ethyl]phosphonic acid | Authors: | Gao, J, Ko, T.P, Huang, C.H, Oldfield, E, Guo, R.T. | Deposit date: | 2014-08-29 | Release date: | 2015-02-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Antibacterial drug leads: DNA and enzyme multitargeting. J.Med.Chem., 58, 2015
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6INU
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6INO
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5TIA
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![BU of 5tia by Molmil](/molmil-images/mine/5tia) | Crystal structure of human TDO in complex with Trp, Northeast Structural Genomics Consortium Target HR6161 | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, TRYPTOPHAN, Tryptophan 2,3-dioxygenase | Authors: | Forouhar, F, Lewis-Ballester, A, Lew, S, Karkashon, S, Seetharaman, J, Yeh, S.R, Tong, L. | Deposit date: | 2016-10-01 | Release date: | 2016-10-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.441 Å) | Cite: | Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase. Sci Rep, 6, 2016
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4IWY
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![BU of 4iwy by Molmil](/molmil-images/mine/4iwy) | SeMet-substituted RimK structure | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLUTAMIC ACID, Ribosomal protein S6 modification protein, ... | Authors: | Shi, D, Zhao, G, Jin, Z, Allewell, N.M, Tuchman, M. | Deposit date: | 2013-01-24 | Release date: | 2013-05-08 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure and function of Escherichia coli RimK, an ATP-grasp fold, l-glutamyl ligase enzyme. Proteins, 81, 2013
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3KMY
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![BU of 3kmy by Molmil](/molmil-images/mine/3kmy) | Structure of BACE bound to SCH12472 | Descriptor: | 3-[2-(3-chlorophenyl)ethyl]pyridin-2-amine, Beta-secretase 1 | Authors: | Strickland, C, Wang, Y. | Deposit date: | 2009-11-11 | Release date: | 2010-01-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel muM Leads for the Development of nM BACE-1 (beta-Site APP Cleaving Enzyme 1) Inhibitors. J.Med.Chem., 53, 2010
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6J30
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![BU of 6j30 by Molmil](/molmil-images/mine/6j30) | yeast proteasome in Ub-engaged state (C2) | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, ... | Authors: | Cong, Y. | Deposit date: | 2019-01-03 | Release date: | 2019-03-20 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural Snapshots of 26S Proteasome Reveal Tetraubiquitin-Induced Conformations. Mol. Cell, 73, 2019
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6J2N
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![BU of 6j2n by Molmil](/molmil-images/mine/6j2n) | yeast proteasome in substrate-processing state (C3-b) | Descriptor: | 26S protease regulatory subunit 4 homolog, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B homolog, ... | Authors: | Cong, Y. | Deposit date: | 2019-01-02 | Release date: | 2019-03-20 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (7.5 Å) | Cite: | Structural Snapshots of 26S Proteasome Reveal Tetraubiquitin-Induced Conformations. Mol. Cell, 73, 2019
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3KMX
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![BU of 3kmx by Molmil](/molmil-images/mine/3kmx) | Structure of BACE bound to SCH346572 | Descriptor: | 4-butoxy-3-chlorobenzyl imidothiocarbamate, Beta-secretase 1 | Authors: | Strickland, C, Wang, Y. | Deposit date: | 2009-11-11 | Release date: | 2010-01-19 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel muM Leads for the Development of nM BACE-1 (beta-Site APP Cleaving Enzyme 1) Inhibitors. J.Med.Chem., 53, 2010
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4ORD
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4OVG
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![BU of 4ovg by Molmil](/molmil-images/mine/4ovg) | E. coli sliding clamp in complex with (R)-9-(2-amino-2-oxoethyl)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-2-carboxylic acid | Descriptor: | (2R)-9-(2-amino-2-oxoethyl)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-2-carboxylic acid, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Yin, Z, Oakley, A.J. | Deposit date: | 2014-02-21 | Release date: | 2014-03-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Bacterial Sliding Clamp Inhibitors that Mimic the Sequential Binding Mechanism of Endogenous Linear Motifs. J.Med.Chem., 58, 2015
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3KN0
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![BU of 3kn0 by Molmil](/molmil-images/mine/3kn0) | Structure of BACE bound to SCH708236 | Descriptor: | 3-[2-(3-{[(furan-2-ylmethyl)(methyl)amino]methyl}phenyl)ethyl]pyridin-2-amine, Beta-secretase 1, L(+)-TARTARIC ACID | Authors: | Strickland, C, Wang, Y. | Deposit date: | 2009-11-11 | Release date: | 2010-01-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel muM Leads for the Development of nM BACE-1 (beta-Site APP Cleaving Enzyme 1) Inhibitors. J.Med.Chem., 53, 2010
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4IWX
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![BU of 4iwx by Molmil](/molmil-images/mine/4iwx) | Rimk structure at 2.85A | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLUTAMIC ACID, Ribosomal protein S6 modification protein, ... | Authors: | Shi, D, Zhao, G, Jin, Z, Allewell, N.M, Tuchman, M. | Deposit date: | 2013-01-24 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.854 Å) | Cite: | Structure and function of Escherichia coli RimK, an ATP-grasp fold, l-glutamyl ligase enzyme. Proteins, 81, 2013
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6J2C
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![BU of 6j2c by Molmil](/molmil-images/mine/6j2c) | Yeast proteasome in translocation competent state (C3-a) | Descriptor: | 26S protease regulatory subunit 4 homolog, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B homolog, ... | Authors: | Cong, Y. | Deposit date: | 2019-01-01 | Release date: | 2019-03-13 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Structural Snapshots of 26S Proteasome Reveal Tetraubiquitin-Induced Conformations. Mol. Cell, 73, 2019
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4OVF
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![BU of 4ovf by Molmil](/molmil-images/mine/4ovf) | E. coli sliding clamp in complex with (R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-2-carboxylic acid | Descriptor: | (2R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-2-carboxylic acid, CALCIUM ION, CHLORIDE ION, ... | Authors: | Yin, Z, Oakley, A.J. | Deposit date: | 2014-02-21 | Release date: | 2014-03-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Bacterial Sliding Clamp Inhibitors that Mimic the Sequential Binding Mechanism of Endogenous Linear Motifs. J.Med.Chem., 58, 2015
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6J2X
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![BU of 6j2x by Molmil](/molmil-images/mine/6j2x) | Yeast proteasome in resting state (C1-a) | Descriptor: | 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG, 26S PROTEASOME REGULATORY SUBUNIT RPN5, 26S proteasome complex subunit SEM1, ... | Authors: | Cong, Y. | Deposit date: | 2019-01-03 | Release date: | 2019-03-13 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural Snapshots of 26S Proteasome Reveal Tetraubiquitin-Induced Conformations. Mol. Cell, 73, 2019
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