4WA6
 
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1APL
 | | CRYSTAL STRUCTURE OF A MAT-ALPHA2 HOMEODOMAIN-OPERATOR COMPLEX SUGGESTS A GENERAL MODEL FOR HOMEODOMAIN-DNA INTERACTIONS | | Descriptor: | DNA (5'-D(*AP*CP*AP*TP*GP*TP*AP*AP*TP*TP*CP*AP*TP*TP*TP*AP*C P*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*GP*TP*AP*AP*AP*TP*GP*AP*AP*TP*TP*A P*CP*AP*TP*G)-3'), PROTEIN (MAT-ALPHA2 HOMEODOMAIN) | | Authors: | Wolberger, C, Vershon, A.K, Liu, B, Johnson, A.D, Pabo, C.O. | | Deposit date: | 1993-10-04 | | Release date: | 1993-10-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions.
Cell(Cambridge,Mass.), 67, 1991
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3PDH
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4W4U
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5H84
 | | Human Gcn5 bound to propionyl-CoA | | Descriptor: | 1,2-ETHANEDIOL, Histone acetyltransferase KAT2A, ISOPROPYL ALCOHOL, ... | | Authors: | Wolberger, C, Ringel, A.E. | | Deposit date: | 2015-12-23 | | Release date: | 2016-03-23 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for acyl-group discrimination by human Gcn5L2.
Acta Crystallogr D Struct Biol, 72, 2016
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5H86
 | | Human Gcn5 bound to butyryl-CoA | | Descriptor: | 1,2-ETHANEDIOL, Butyryl Coenzyme A, Histone acetyltransferase KAT2A | | Authors: | Wolberger, C, Ringel, A.E. | | Deposit date: | 2015-12-23 | | Release date: | 2016-03-23 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Structural basis for acyl-group discrimination by human Gcn5L2.
Acta Crystallogr D Struct Biol, 72, 2016
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2GMI
 | | Mms2/Ubc13~Ubiquitin | | Descriptor: | Ubiquitin, Ubiquitin-conjugating enzyme E2 13, Ubiquitin-conjugating enzyme variant MMS2 | | Authors: | Wolberger, C, Eddins, M.J, Carlile, C.M, Gomez, K.G, Pickart, C.M. | | Deposit date: | 2006-04-06 | | Release date: | 2006-09-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation.
Nat.Struct.Mol.Biol., 13, 2006
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1S7G
 | | Structural Basis for the Mechanism and Regulation of Sir2 Enzymes | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5-DIPHOSPHORIBOSE, HEXAETHYLENE GLYCOL, ... | | Authors: | Avalos, J.L, Boeke, J.D, Wolberger, C. | | Deposit date: | 2004-01-29 | | Release date: | 2004-03-23 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for the mechanism and regulation of sir2 enzymes
Mol.Cell, 13, 2004
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7UD5
 | | Complex between MLL1-WRAD and an H2B-ubiquitinated nucleosome | | Descriptor: | 601 DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Niklas, H.A, Rahman, S, Worden, E.J, Wolberger, C. | | Deposit date: | 2022-03-18 | | Release date: | 2022-09-21 | | Last modified: | 2022-10-05 | | Method: | ELECTRON MICROSCOPY (4.25 Å) | | Cite: | Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome.
Proc.Natl.Acad.Sci.USA, 119, 2022
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1AKH
 | | MAT A1/ALPHA2/DNA TERNARY COMPLEX | | Descriptor: | DNA (5'-D(*TP*AP*CP*AP*TP*GP*TP*AP*AP*AP*AP*AP*TP*TP*TP*AP*C P*AP*TP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*GP*AP*TP*GP*TP*AP*AP*AP*TP*TP*TP*TP*TP*A P*CP*AP*TP*G)-3'), PROTEIN (MATING-TYPE PROTEIN A-1), ... | | Authors: | Li, T, Jin, Y, Vershon, A.K, Wolberger, C. | | Deposit date: | 1997-05-19 | | Release date: | 1998-05-20 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of the MATa1/MATalpha2 homeodomain heterodimer in complex with DNA containing an A-tract.
Nucleic Acids Res., 26, 1998
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8DU4
 | | Complex between RbBP5-WDR5 and an H2B-ubiquitinated nucleosome | | Descriptor: | 601 DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Niklas, H.A, Rahman, S, Worden, E.J, Wolberger, C. | | Deposit date: | 2022-07-26 | | Release date: | 2022-09-21 | | Last modified: | 2022-10-05 | | Method: | ELECTRON MICROSCOPY (3.55 Å) | | Cite: | Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome.
Proc.Natl.Acad.Sci.USA, 119, 2022
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1JAT
 | | Mms2/Ubc13 Ubiquitin Conjugating Enzyme Complex | | Descriptor: | Ubiquitin-Conjugating Enzyme E2-17.5 KDA, Ubiquitin-Conjugating Enzyme Variant Mms2 | | Authors: | VanDemark, A.P, Hofmann, R.M, Tsui, C, Pickart, C.M, Wolberger, C. | | Deposit date: | 2001-05-31 | | Release date: | 2001-06-20 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer.
Cell(Cambridge,Mass.), 105, 2001
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1JBB
 | | Ubiquitin Conjugating Enzyme, Ubc13 | | Descriptor: | ubiquitin conjugating enzyme E2-17.5 KDA | | Authors: | VanDemark, A.P, Hofmann, R.M, Tsui, C, Pickart, C.M, Wolberger, C. | | Deposit date: | 2001-06-03 | | Release date: | 2001-06-20 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer.
Cell(Cambridge,Mass.), 105, 2001
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4TWJ
 | | The structure of Sir2Af2 bound to a myristoylated histone peptide | | Descriptor: | ACETATE ION, GLYCEROL, Histone H4 peptide, ... | | Authors: | Ringel, A.E, Roman, C, Wolberger, C. | | Deposit date: | 2014-06-30 | | Release date: | 2014-12-03 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2.
Protein Sci., 23, 2014
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6AQR
 | | SAGA DUB module Ubp8(C146A)/Sgf11/Sus1/Sgf73 bound to monoubiquitin | | Descriptor: | Polyubiquitin-C, SAGA-associated factor 11, SAGA-associated factor 73, ... | | Authors: | Morrow, M.E, Morgan, M.T, Wolberger, C. | | Deposit date: | 2017-08-21 | | Release date: | 2018-07-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins.
EMBO Rep., 19, 2018
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4ZUX
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6VEN
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3JR3
 | | Sir2 bound to acetylated peptide | | Descriptor: | Acetylated Peptide, NAD-dependent deacetylase, ZINC ION | | Authors: | Hawse, W.F, Wolberger, C. | | Deposit date: | 2009-09-08 | | Release date: | 2009-09-29 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure-based mechanism of ADP-ribosylation by sirtuins.
J.Biol.Chem., 284, 2009
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3MHS
 | | Structure of the SAGA Ubp8/Sgf11/Sus1/Sgf73 DUB module bound to ubiquitin aldehyde | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Protein SUS1, ... | | Authors: | Samara, N.L, Datta, A.B, Berndsen, C.E, Zhang, X, Yao, T, Cohen, R.E, Wolberger, C. | | Deposit date: | 2010-04-08 | | Release date: | 2010-04-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Structural insights into the assembly and function of the SAGA deubiquitinating module.
Science, 328, 2010
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3MHH
 | | Structure of the SAGA Ubp8/Sgf11/Sus1/Sgf73 DUB module | | Descriptor: | Protein SUS1, SAGA-associated factor 11, SAGA-associated factor 73, ... | | Authors: | Samara, N.L, Datta, A.B, Berndsen, C.E, Zhang, X, Yao, T, Cohen, R.E, Wolberger, C. | | Deposit date: | 2010-04-08 | | Release date: | 2010-04-21 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structural insights into the assembly and function of the SAGA deubiquitinating module.
Science, 328, 2010
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4LDT
 | | The structure of h/ceOTUB1-ubiquitin aldehyde-UBCH5B~Ub | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, Ubiquitin, ... | | Authors: | Wiener, R, DiBello, A.T, Lombardi, P.M, Guzzo, C.M, Zhang, X, Matunis, M.J, Wolberger, C. | | Deposit date: | 2013-06-25 | | Release date: | 2013-08-14 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1.
Nat.Struct.Mol.Biol., 20, 2013
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4FJC
 | | Structure of the SAGA Ubp8/Sgf11(1-72, Delta-ZnF)/Sus1/Sgf73 DUB module | | Descriptor: | GLYCEROL, Protein SUS1, SAGA-associated factor 11, ... | | Authors: | Samara, N.L, Ringel, A.E, Wolberger, C. | | Deposit date: | 2012-06-11 | | Release date: | 2012-07-25 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.826 Å) | | Cite: | A Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity.
Structure, 20, 2012
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1PUF
 | | Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA | | Descriptor: | 5'-D(*AP*CP*TP*CP*TP*AP*TP*GP*AP*TP*TP*TP*AP*CP*GP*AP*CP*GP*CP*T)-3', 5'-D(*TP*AP*GP*CP*GP*TP*CP*GP*TP*AP*AP*AP*TP*CP*AP*TP*AP*GP*AP*G)-3', Homeobox protein Hox-A9, ... | | Authors: | Laronde-Leblanc, N.A, Wolberger, C. | | Deposit date: | 2003-06-24 | | Release date: | 2003-09-02 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | STRUCTURE OF HOXA9 AND PBX1 BOUND TO DNA: HOX HEXAPEPTIDE AND DNA RECOGNITION ANTERIOR TO POSTERIOR
Genes Dev., 17, 2003
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2O6V
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1ERJ
 | | CRYSTAL STRUCTURE OF THE C-TERMINAL WD40 DOMAIN OF TUP1 | | Descriptor: | TRANSCRIPTIONAL REPRESSOR TUP1 | | Authors: | Sprague, E.R, Redd, M.J, Johnson, A.D, Wolberger, C. | | Deposit date: | 2000-04-06 | | Release date: | 2000-07-26 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of the C-terminal domain of Tup1, a corepressor of transcription in yeast.
EMBO J., 19, 2000
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