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ATOMIC STRUCTURE OF ADENOSINE DEAMINASE COMPLEXED WITH A TRANSITION-STATE ANALOG: UNDERSTANDING CATALYSIS AND IMMUNODEFICIENCY MUTATIONS
Descriptor:	6-HYDROXY-7,8-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION
Authors:	Wilson, D.K, Quiocho, F.A.
Deposit date:	1994-12-02
Release date:	1995-03-31
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations. Science, 252, 1991

1ADD

A PRE-TRANSITION STATE MIMIC OF AN ENZYME: X-RAY STRUCTURE OF ADENOSINE DEAMINASE WITH BOUND 1-DEAZA-ADENOSINE AND ZINC-ACTIVATED WATER
Descriptor:	1-DEAZA-ADENOSINE, ADENOSINE DEAMINASE, ZINC ION
Authors:	Wilson, D.K, Quiocho, F.A.
Deposit date:	1992-12-22
Release date:	1994-01-31
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	A pre-transition-state mimic of an enzyme: X-ray structure of adenosine deaminase with bound 1-deazaadenosine and zinc-activated water. Biochemistry, 32, 1993

1FRB

FR-1 PROTEIN/NADPH/ZOPOLRESTAT COMPLEX
Descriptor:	3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, FR-1 PROTEIN, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:	Wilson, D.K, Quiocho, F.A.
Deposit date:	1995-08-08
Release date:	1996-10-14
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	1.7 A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor. Biochemistry, 34, 1995

3CZM

T. Gondii bradyzoite-specific LDH (LDH2) in complex with NAD and OXQ
Descriptor:	4-HYDROXY-1,2,5-OXADIAZOLE-3-CARBOXYLIC ACID, L-lactate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:	Wilson, D.K, Susko, M.S.
Deposit date:	2008-04-29
Release date:	2009-06-02
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	T. Gondii bradyzoite-specific LDH (LDH2) in complex with NAD and OXQ To be Published

5UX1

Protein 43 with aldehyde deformylating oxygenase activity from Synechococcus
Descriptor:	FE (III) ION, tRNA-(MS(2)IO(6)A)-hydroxylase-like
Authors:	Wilson, D.K, Mak, W.S, Siegel, J.B.
Deposit date:	2017-02-21
Release date:	2018-02-28
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Protein 43 with aldehyde deformylating oxygenase activity from Synechococcus To Be Published

5UXI

Protein 4 with aldehyde deformylating oxygenase activity from Nostoc puntiforme
Descriptor:	Aldehyde decarbonylase, DECYLAMINE-N,N-DIMETHYL-N-OXIDE
Authors:	Wilson, D.K, Mak, W.S, Siegel, J.B.
Deposit date:	2017-02-22
Release date:	2018-02-28
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Protein 4 with aldehyde deformylating oxygenase activity from Nostoc puntiforme To Be Published

5UX2

Protein 19 with aldehyde deformylating oxidase activity from Synechococcus
Descriptor:	Aldehyde decarbonylase, FE (III) ION, PROPANOIC ACID
Authors:	Wilson, D.K, Mak, W.S, Siegel, J.B.
Deposit date:	2017-02-21
Release date:	2018-02-28
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.99 Å)
Cite:	Protein 19 with aldehyde deformylating oxidase activity from Synechococcus To Be Published

5UWZ

Protein 12 with aldehyde deformylating oxygenase activity from Gloeobacter violaceus
Descriptor:	1,2-ETHANEDIOL, Aldehyde decarbonylase, STEARIC ACID
Authors:	Wilson, D.K.
Deposit date:	2017-02-21
Release date:	2018-02-28
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (1.25 Å)
Cite:	Protein 12 with aldehyde deformylating oxygenase activity from Gloeobacter violaceus To Be Published

5UXG

Protein 84 with aldehyde deformylating oxygenase activity from Sulfolobus tokodaii (monoclinic)
Descriptor:	PHOSPHATE ION, aldehyde deformylating oxygenase
Authors:	Wilson, D.K, Mak, W.S, Siegel, J.B.
Deposit date:	2017-02-22
Release date:	2018-02-28
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.72 Å)
Cite:	Protein 84 with aldehyde deformylating oxygenase activity from Sulfolobus tokodaii (monoclinic) To Be Published

5V4T

Protein 84 with aldehyde deformylating oxygenase activity from Sulfolobus tokodaii (orthorhombic form)
Descriptor:	1,2-ETHANEDIOL, FE (III) ION, hypothetic aldehyde deformylating oxygenase
Authors:	Wilson, D.K, Mak, W.S, Siegel, J.B.
Deposit date:	2017-03-10
Release date:	2018-03-14
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Protein 84 with aldehyde deformylating oxygenase activity from Sulfolobus tokodaii (orthorhombic form) To Be Published

1YFQ

High resolution S. cerevisiae Bub3 mitotic checkpoint protein
Descriptor:	ACETATE ION, CALCIUM ION, Cell cycle arrest protein BUB3
Authors:	Wilson, D.K, Cerna, D, Chew, E.
Deposit date:	2005-01-03
Release date:	2005-01-11
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.1 Å)
Cite:	The 1.1-a structure of the spindle checkpoint protein bub3p reveals functional regions. J.Biol.Chem., 280, 2005

1ADS

AN UNLIKELY SUGAR SUBSTRATE SITE IN THE 1.65 ANGSTROMS STRUCTURE OF THE HUMAN ALDOSE REDUCTASE HOLOENZYME IMPLICATED IN DIABETIC COMPLICATIONS
Descriptor:	ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:	Wilson, D.K, Quiocho, F.A.
Deposit date:	1992-07-08
Release date:	1993-10-31
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science, 257, 1992

1MAR

REFINED 1.8 ANGSTROMS STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH THE POTENT INHIBITOR ZOPOLRESTAT
Descriptor:	3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:	Wilson, D.K, Quiocho, F.A.
Deposit date:	1993-07-20
Release date:	1995-07-20
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat. Proc.Natl.Acad.Sci.USA, 90, 1993

1UIP

ADENOSINE DEAMINASE (HIS 238 GLU MUTANT)
Descriptor:	ADENOSINE DEAMINASE, PURINE RIBOSIDE, ZINC ION
Authors:	Wilson, D.K, Quiocho, F.A.
Deposit date:	1996-08-30
Release date:	1997-06-24
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation. Biochemistry, 35, 1996

1UIO

ADENOSINE DEAMINASE (HIS 238 ALA MUTANT)
Descriptor:	6-HYDROXY-7,8-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION
Authors:	Wilson, D.K, Quiocho, F.A.
Deposit date:	1996-08-30
Release date:	1997-06-24
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation. Biochemistry, 35, 1996

1FKW

MURINE ADENOSINE DEAMINASE (D295E)
Descriptor:	ADENOSINE DEAMINASE, PURINE RIBOSIDE, ZINC ION
Authors:	Wilson, D.K, Quiocho, F.A.
Deposit date:	1996-02-29
Release date:	1996-08-01
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase. Biochemistry, 35, 1996

1FKX

MURINE ADENOSINE DEAMINASE (D296A)
Descriptor:	6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION
Authors:	Wilson, D.K, Quiocho, F.A.
Deposit date:	1996-02-29
Release date:	1996-08-01
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase. Biochemistry, 35, 1996

1ABF

SUBSTRATE SPECIFICITY AND AFFINITY OF A PROTEIN MODULATED BY BOUND WATER MOLECULES
Descriptor:	L-ARABINOSE-BINDING PROTEIN, alpha-D-fucopyranose, beta-D-fucopyranose
Authors:	Wilson, D.K, Quiocho, F.A.
Deposit date:	1992-04-23
Release date:	1993-10-31
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Substrate specificity and affinity of a protein modulated by bound water molecules. Nature, 340, 1989

4RJE

Aerococcus viridans L-lactate oxidase mutant
Descriptor:	1,2-ETHANEDIOL, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, Lactate oxidase, ...
Authors:	Rainer, D, Nidetzky, B, Wilson, D.K.
Deposit date:	2014-10-08
Release date:	2014-12-03
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	The Ala95-to-Gly substitution in Aerococcus viridans l-lactate oxidase revisited - structural consequences at the catalytic site and effect on reactivity with O2 and other electron acceptors. Febs J., 282, 2015

5VM0

The hapten triclocarban bound to the single domain camelid nanobody VHH T9
Descriptor:	1,2-ETHANEDIOL, Camelid Nanobody VHH T9, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea
Authors:	Wogulis, L.A, Wogulis, M.D, Tabares-da Rosa, S, Gonzalez-Sapienza, G, Wilson, D.K.
Deposit date:	2017-04-26
Release date:	2018-05-02
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.79 Å)
Cite:	Structure and specificity of several triclocarban-binding single domain camelid antibody fragments. J. Mol. Recognit., 32, 2019

5VLV

The apo form of the triclocarban-binding single domain camelid nanobody VHH T9
Descriptor:	Single Domain Camelid Nanobody VHH T9
Authors:	Tabares-da Rosa, S, Gonzalez-Sapienza, G, Wilson, D.K.
Deposit date:	2017-04-26
Release date:	2018-05-02
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.35 Å)
Cite:	Structure and specificity of several triclocarban-binding single domain camelid antibody fragments. J. Mol. Recognit., 32, 2019

8FH6

Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Two AT-001
Descriptor:	(8-oxo-7-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-7,8-dihydropyrazino[2,3-d]pyridazin-5-yl)acetic acid, 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B1, ...
Authors:	Arenas, R, Wilson, D.K.
Deposit date:	2022-12-13
Release date:	2023-12-20
Method:	X-RAY DIFFRACTION (1.952 Å)
Cite:	Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Two AT-001 To Be Published

8FHB

Protein 32 with aldehyde deformylating oxidase activity from Synechococcus sp.
Descriptor:	FE (III) ION, tRNA-(MS[2]IO[6]A)-hydroxylase
Authors:	Arenas, R, Wilson, D.K, Mak, W.S, Siegel, J.B.
Deposit date:	2022-12-13
Release date:	2023-12-20
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Protein 32 with aldehyde deformylating oxidase activity from Synechococcus sp. To Be Published

8FH8

Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-003 Soaked In Hydrogen Peroxide
Descriptor:	1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B1, HYDROGEN PEROXIDE, ...
Authors:	Arenas, R, Wilson, D.K.
Deposit date:	2022-12-13
Release date:	2023-12-20
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-003 Soaked In Hydrogen Peroxide To Be Published

8FH7

Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-003
Descriptor:	1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:	Arenas, R, Wilson, D.K.
Deposit date:	2022-12-13
Release date:	2023-12-20
Method:	X-RAY DIFFRACTION (1.45 Å)
Cite:	Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And AT-003 To Be Published

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Displayed results:	25
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