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4V3N
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BU of 4v3n by Molmil
Membrane bound pleurotolysin prepore (TMH2 strand lock) trapped with engineered disulphide cross-link
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-20
Release date:2015-02-18
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (14 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
3J2T
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BU of 3j2t by Molmil
An improved model of the human apoptosome
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Apoptotic protease-activating factor 1, Cytochrome c, ...
Authors:Yuan, S, Topf, M, Akey, C.W.
Deposit date:2012-12-23
Release date:2013-04-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (9.5 Å)
Cite:Changes in apaf-1 conformation that drive apoptosome assembly.
Biochemistry, 52, 2013
4AAQ
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BU of 4aaq by Molmil
ATP-triggered molecular mechanics of the chaperonin GroEL
Descriptor: 60 KDA CHAPERONIN, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Clare, D.K, Vasishtan, D, Stagg, S, Quispe, J, Farr, G.W, Topf, M, Horwich, A.L, Saibil, H.R.
Deposit date:2011-12-05
Release date:2012-12-12
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (8 Å)
Cite:ATP-Triggered Conformational Changes Delineate Substrate-Binding and -Folding Mechanics of the Groel Chaperonin.
Cell(Cambridge,Mass.), 149, 2012
6Z9M
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BU of 6z9m by Molmil
Pseudoatomic model of the pre-fusion conformation of glycoprotein B of Herpes simplex virus 1
Descriptor: Envelope glycoprotein B
Authors:Vollmer, B, Prazak, V, Vasishtan, D, Jefferys, E.E, Hernandez-Duran, A, Vallbracht, M, Klupp, B, Mettenleiter, T.C, Backovic, M, Rey, F.A, Topf, M, Gruenewald, K.
Deposit date:2020-06-04
Release date:2020-10-07
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (9.1 Å)
Cite:The prefusion structure of herpes simplex virus glycoprotein B.
Sci Adv, 6, 2020
5OGC
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BU of 5ogc by Molmil
Molecular basis of human kinesin-8 function and inhibition
Descriptor: 4-chloranyl-2-nitro-1-(phenylsulfonyl)benzene, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Locke, J, Joseph, A.P, Topf, M, Moores, C.A.
Deposit date:2017-07-12
Release date:2017-10-25
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structural basis of human kinesin-8 function and inhibition.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
2X7N
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BU of 2x7n by Molmil
Mechanism of eIF6s anti-association activity
Descriptor: 60S RIBOSOMAL PROTEIN L23, 60S RIBOSOMAL PROTEIN L24-A, EUKARYOTIC TRANSLATION INITIATION FACTOR 6, ...
Authors:Gartmann, M, Blau, M, Armache, J.-P, Mielke, T, Topf, M, Beckmann, R.
Deposit date:2010-03-02
Release date:2010-03-31
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (11.8 Å)
Cite:Mechanism of Eif6-Mediated Inhibition of Ribosomal Subunit Joining.
J.Biol.Chem., 285, 2010
7PAG
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BU of 7pag by Molmil
The pore conformation of lymphocyte perforin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Perforin-1
Authors:Ivanova, M.E, Lukoyanova, N, Malhotra, S, Topf, M, Trapani, J.A, Voskoboinik, I, Saibil, H.R.
Deposit date:2021-07-29
Release date:2022-02-16
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (4 Å)
Cite:The pore conformation of lymphocyte perforin.
Sci Adv, 8, 2022
3DEG
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BU of 3deg by Molmil
Complex of elongating Escherichia coli 70S ribosome and EF4(LepA)-GMPPNP
Descriptor: 30S RNA helix 14, 30S RNA helix 8, 30S ribosomal protein S12, ...
Authors:Connell, S.R, Topf, M, Qin, Y, Wilson, D.N, Mielke, T, Fucini, P, Nierhaus, K.H, Spahn, C.M.T.
Deposit date:2008-06-10
Release date:2008-08-19
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (10.9 Å)
Cite:A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
Nat.Struct.Mol.Biol., 15, 2008
4L0J
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BU of 4l0j by Molmil
Structure of a translocation signal domain mediating conjugative transfer by type IV secretion systems
Descriptor: DNA helicase I, MAGNESIUM ION, SULFATE ION
Authors:Redzej, A, Ilangovan, A, Lang, S, Gruber, C.J, Topf, M, Zangger, K, Zechner, E.L, Waksman, G.
Deposit date:2013-05-31
Release date:2013-06-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of a translocation signal domain mediating conjugative transfer by type IV secretion systems.
Mol.Microbiol., 89, 2013
4V2T
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BU of 4v2t by Molmil
Membrane embedded pleurotolysin pore with 13 fold symmetry
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-15
Release date:2015-02-18
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (11 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4UXP
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BU of 4uxp by Molmil
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-3 MOTOR DOMAIN, ...
Authors:Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C.
Deposit date:2014-08-27
Release date:2014-09-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
4UXY
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BU of 4uxy by Molmil
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Descriptor: ALPHA TUBULIN, BETA TUBULIN, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C.
Deposit date:2014-08-27
Release date:2014-09-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
6H03
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BU of 6h03 by Molmil
OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ...
Authors:Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D.
Deposit date:2018-07-06
Release date:2018-12-19
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9, 2018
6H04
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BU of 6h04 by Molmil
Closed conformation of the Membrane Attack Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ...
Authors:Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D.
Deposit date:2018-07-06
Release date:2018-12-19
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9, 2018
1NX8
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BU of 1nx8 by Molmil
Structure of carbapenem synthase (CarC) complexed with N-acetyl proline
Descriptor: 1-ACETYL-L-PROLINE, 2-OXOGLUTARIC ACID, Carbapenem synthase, ...
Authors:Clifton, I.J, Doan, L.X, Sleeman, M.C, Topf, M, Suzuki, H, Wilmouth, R.C, Schofield, C.J.
Deposit date:2003-02-10
Release date:2003-06-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of carbapenem synthase (CarC).
J.Biol.Chem., 278, 2003
1NX4
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BU of 1nx4 by Molmil
The crystal structure of carbapenem synthase (CarC)
Descriptor: 2-OXOGLUTARIC ACID, Carbapenem synthase, FE (III) ION
Authors:Clifton, I.J, Doan, L.X, Sleeman, M.C, Topf, M, Suzuki, H, Wilmouth, R.C, Schofield, C.J.
Deposit date:2003-02-08
Release date:2003-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of carbapenem synthase (CarC).
J.Biol.Chem., 278, 2003
4V4L
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BU of 4v4l by Molmil
Structure of the Drosophila apoptosome
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Apaf-1 related killer DARK, MAGNESIUM ION
Authors:Yuan, S, Topf, M, Akey, C.W, Ludtke, S.J.
Deposit date:2010-10-04
Release date:2014-07-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (6.9 Å)
Cite:Structure of the Drosophila apoptosome at 6.9 angstrom resolution
Structure, 19, 2011
4UXS
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BU of 4uxs by Molmil
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-3 MOTOR DOMAIN, ...
Authors:Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C.
Deposit date:2014-08-27
Release date:2014-09-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
4UXO
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BU of 4uxo by Molmil
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-3 MOTOR DOMAIN, ...
Authors:Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C.
Deposit date:2014-08-27
Release date:2014-09-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
4UXR
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BU of 4uxr by Molmil
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C.
Deposit date:2014-08-27
Release date:2014-09-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
4UY0
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BU of 4uy0 by Molmil
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C.
Deposit date:2014-08-27
Release date:2014-09-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (7.7 Å)
Cite:Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
3B63
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BU of 3b63 by Molmil
Actin filament model in the extended form of acromsomal bundle in the Limulus sperm
Descriptor: Actin
Authors:Cong, Y, Topf, M, Sali, A, Matsudaira, P, Dougherty, M, Chiu, W, Schmid, M.F.
Deposit date:2007-10-26
Release date:2008-11-18
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (9.5 Å)
Cite:Crystallographic conformers of actin in a biologically active bundle of filaments.
J.Mol.Biol., 375, 2008
3B5U
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BU of 3b5u by Molmil
Actin filament model from extended form of acromsomal bundle in the Limulus sperm
Descriptor: Actin, alpha skeletal muscle
Authors:Cong, Y, Topf, M, Sali, A, Matsudaira, P, Dougherty, M, Chiu, W, Schmid, M.F.
Deposit date:2007-10-26
Release date:2008-04-15
Last modified:2024-02-21
Method:ELECTRON CRYSTALLOGRAPHY (9.5 Å)
Cite:Crystallographic conformers of actin in a biologically active bundle of filaments
J.Mol.Biol., 375, 2008
7NBA
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BU of 7nba by Molmil
Plasmodium falciparum kinesin-5 motor domain bound to AMPPNP, complexed with 14 protofilament microtubule.
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Kinesin motor domain-containing protein,Kinesin motor domain-containing protein, MAGNESIUM ION, ...
Authors:Cook, A.D, Roberts, A, Atherton, J, Tewari, R, Topf, M, Moores, C.A.
Deposit date:2021-01-25
Release date:2021-10-13
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition.
J.Biol.Chem., 297, 2021
7NB8
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BU of 7nb8 by Molmil
Plasmodium falciparum kinesin-5 motor domain without nucleotide, complexed with 14 protofilament microtubule.
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Kinesin-5, MAGNESIUM ION, ...
Authors:Cook, A.D, Roberts, A, Atherton, J, Tewari, R, Topf, M, Moores, C.A.
Deposit date:2021-01-25
Release date:2021-10-13
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition.
J.Biol.Chem., 297, 2021

 

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