2MJF
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![BU of 2mjf by Molmil](/molmil-images/mine/2mjf) | Solution structure of the complex between the yeast Rsa1 and Hit1 proteins | Descriptor: | Protein HIT1, Ribosome assembly 1 protein | Authors: | Quinternet, M, Roth, B, Back, R, Jacquemin, C, Manival, X. | Deposit date: | 2014-01-08 | Release date: | 2014-09-10 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction. Nucleic Acids Res., 42, 2014
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6HYK
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![BU of 6hyk by Molmil](/molmil-images/mine/6hyk) | NMR solution structure of the C/D box snoRNA U14 | Descriptor: | RNA (31-MER) | Authors: | Chagot, M.E, Quinternet, M, Rothe, B, Charpentier, B, Coutant, J, Manival, X, Lebars, I. | Deposit date: | 2018-10-22 | Release date: | 2019-04-24 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | The yeast C/D box snoRNA U14 adopts a "weak" K-turn like conformation recognized by the Snu13 core protein in solution. Biochimie, 164, 2019
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2LSU
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![BU of 2lsu by Molmil](/molmil-images/mine/2lsu) | The NMR high resolution structure of yeast Tah1 in a free form | Descriptor: | TPR repeat-containing protein associated with Hsp90 | Authors: | Back, R, Dominguez, C, Rothe, B, Bobo, C, Beaufils, C, Morera, S, Meyer, P, Charpentier, B, Branlant, C, Allain, F, Manival, X. | Deposit date: | 2012-05-07 | Release date: | 2013-05-22 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | High-Resolution Structural Analysis Shows How Tah1 Tethers Hsp90 to the R2TP Complex. Structure, 21, 2013
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2LSV
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![BU of 2lsv by Molmil](/molmil-images/mine/2lsv) | The NMR high resolution structure of yeast Tah1 in complex with the Hsp90 C-terminal tail | Descriptor: | ATP-dependent molecular chaperone HSP82, TPR repeat-containing protein associated with Hsp90 | Authors: | Back, R, Dominguez, C, Rothe, B, Bobo, C, Beaufils, C, Morera, S, Meyer, P, Charpentier, B, Branlant, C, Allain, F, Manival, X. | Deposit date: | 2012-05-07 | Release date: | 2013-05-22 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | High-Resolution Structural Analysis Shows How Tah1 Tethers Hsp90 to the R2TP Complex. Structure, 21, 2013
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2M3F
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![BU of 2m3f by Molmil](/molmil-images/mine/2m3f) | NMR structure of Rsa1p238-259 from S. Cerevisiae | Descriptor: | Ribosome assembly 1 protein | Authors: | Quinternet, M, Manival, X. | Deposit date: | 2013-01-17 | Release date: | 2013-11-27 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Characterization of the interaction between protein Snu13p/15.5K and the Rsa1p/NUFIP factor and demonstration of its functional importance for snoRNP assembly. Nucleic Acids Res., 42, 2014
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4RQN
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![BU of 4rqn by Molmil](/molmil-images/mine/4rqn) | Crystal structure of the native BICC1 SAM Domain R924E mutant | Descriptor: | Protein bicaudal C homolog 1, ZINC ION | Authors: | Leettola, C.N, Cascio, D, Bowie, J.U. | Deposit date: | 2014-11-03 | Release date: | 2016-01-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6. Structure, 26, 2018
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4RQM
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![BU of 4rqm by Molmil](/molmil-images/mine/4rqm) | Crystal structure of the SeMET BICC1 SAM Domain R924E mutant | Descriptor: | Protein bicaudal C homolog 1, ZINC ION | Authors: | Leettola, C.N, Cascio, D, Bowie, J.U. | Deposit date: | 2014-11-03 | Release date: | 2016-01-27 | Last modified: | 2019-10-23 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6. Structure, 26, 2018
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5L85
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![BU of 5l85 by Molmil](/molmil-images/mine/5l85) | |
6THL
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![BU of 6thl by Molmil](/molmil-images/mine/6thl) | Crystal structure of the complex between RTT106 and BCD1 | Descriptor: | Box C/D snoRNA protein 1, Rtt106p | Authors: | Charron, C, Bragantini, B, Manival, X, Charpentier, B. | Deposit date: | 2019-11-20 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity. Nat Commun, 12, 2021
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6NZ2
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![BU of 6nz2 by Molmil](/molmil-images/mine/6nz2) | |
2N95
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![BU of 2n95 by Molmil](/molmil-images/mine/2n95) | |
2N94
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![BU of 2n94 by Molmil](/molmil-images/mine/2n94) | |
2MNJ
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![BU of 2mnj by Molmil](/molmil-images/mine/2mnj) | NMR solution structure of the yeast Pih1 and Tah1 C-terminal domains complex | Descriptor: | Protein interacting with Hsp90 1, TPR repeat-containing protein associated with Hsp90 | Authors: | Quinternet, M, Jacquemin, C, Charpentier, B, Manival, X. | Deposit date: | 2014-04-08 | Release date: | 2015-08-05 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure/Function Analysis of Protein-Protein Interactions Developed by the Yeast Pih1 Platform Protein and Its Partners in Box C/D snoRNP Assembly. J.Mol.Biol., 427, 2015
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7CMV
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![BU of 7cmv by Molmil](/molmil-images/mine/7cmv) | Dopamine Receptor D3R-Gi-PD128907 complex | Descriptor: | (4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, P, Huang, S, Mao, C, Krumm, B, Zhou, X, Tan, Y, Huang, X.-P, Liu, Y, Shen, D.-D, Jiang, Y, Yu, X, Jiang, H, Melcher, K, Roth, B, Cheng, X, Zhang, Y, Xu, H. | Deposit date: | 2020-07-29 | Release date: | 2021-03-10 | Last modified: | 2021-04-07 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structures of the human dopamine D3 receptor-G i complexes. Mol.Cell, 81, 2021
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7CMU
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![BU of 7cmu by Molmil](/molmil-images/mine/7cmu) | Dopamine Receptor D3R-Gi-Pramipexole complex | Descriptor: | (6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, P, Huang, S, Mao, C, Krumm, B, Zhou, X, Tan, Y, Huang, X.-P, Liu, Y, Shen, D.-D, Jiang, Y, Yu, X, Jiang, H, Melcher, K, Roth, B, Cheng, X, Zhang, Y, Xu, H. | Deposit date: | 2020-07-29 | Release date: | 2021-03-10 | Last modified: | 2021-04-07 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structures of the human dopamine D3 receptor-G i complexes. Mol.Cell, 81, 2021
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6PUS
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![BU of 6pus by Molmil](/molmil-images/mine/6pus) | Human TRPM2 bound to ADPR and calcium | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, Transient receptor potential cation channel subfamily M member 2 | Authors: | Du, J, Lu, W, Huang, Y. | Deposit date: | 2019-07-18 | Release date: | 2019-09-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel. Elife, 8, 2019
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6PUR
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![BU of 6pur by Molmil](/molmil-images/mine/6pur) | Human TRPM2 bound to ADPR | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Transient receptor potential cation channel subfamily M member 2 | Authors: | Du, J, Lu, W, Huang, Y. | Deposit date: | 2019-07-18 | Release date: | 2019-09-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel. Elife, 8, 2019
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6PUU
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![BU of 6puu by Molmil](/molmil-images/mine/6puu) | Human TRPM2 bound to 8-Br-cADPR and calcium | Descriptor: | (2R,3R,4S,5R,13R,14S,15R,16R)-24-amino-18-bromo-3,4,14,15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8 ,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13,16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate 8,10-dioxide, CALCIUM ION, Transient receptor potential cation channel subfamily M member 2 | Authors: | Du, J, Lu, W, Huang, Y. | Deposit date: | 2019-07-18 | Release date: | 2019-09-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel. Elife, 8, 2019
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6PUO
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![BU of 6puo by Molmil](/molmil-images/mine/6puo) | Human TRPM2 in the apo state | Descriptor: | Transient receptor potential cation channel subfamily M member 2 | Authors: | Du, J, Lu, W, Huang, Y. | Deposit date: | 2019-07-18 | Release date: | 2019-09-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel. Elife, 8, 2019
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7MVS
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![BU of 7mvs by Molmil](/molmil-images/mine/7mvs) | DNA gyrase complexed with uncleaved DNA and Compound 7 to 2.6A resolution | Descriptor: | (1S)-2-[(2r,5S)-5-{[(2,3-dihydro-1,4-benzodioxin-6-yl)methyl]amino}-1,3-dioxan-2-yl]-1-(3-fluoro-6-methoxyquinolin-4-yl)ethan-1-ol, CHLORIDE ION, DNA (5'-D(P*AP*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), ... | Authors: | Ratigan, S.C, McElroy, C.A. | Deposit date: | 2021-05-15 | Release date: | 2021-10-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.60137153 Å) | Cite: | Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA. J.Med.Chem., 64, 2021
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6WHA
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![BU of 6wha by Molmil](/molmil-images/mine/6wha) | HTR2A bound to 25-CN-NBOH in complex with a mini-Galpha-q protein, beta/gamma subunits and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM) | Descriptor: | 4-(2-{[(2-hydroxyphenyl)methyl]amino}ethyl)-2,5-dimethoxybenzonitrile, G subunit q (Gi2-mini-Gq chimeric), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Skiniotis, G, Roth, B, Kim, K, Panova, O. | Deposit date: | 2020-04-07 | Release date: | 2020-09-23 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor Cell(Cambridge,Mass.), 182, 2020
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