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8QDV
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BU of 8qdv by Molmil
Structure of 14-3-3 zeta delta C with the bivalent tau-pS214-pS324 peptide
Descriptor: 14-3-3 protein zeta/delta, Microtubule-associated protein tau
Authors:van den Oetelaar, M.C.M, Brunsveld, L, Ottmann, C.
Deposit date:2023-08-30
Release date:2024-09-11
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:14-3-3zeta binding increases cytosolic phospho-Tau solubility by decreasing its condensation, aggregation, and microtubule association
To Be Published
8C2E
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BU of 8c2e by Molmil
Structure of 14-3-3 sigma delta C with electrophilic peptide 4IEA-5
Descriptor: 14-3-3 protein sigma, ARG-SER-ALA-SEP-CYS-PRO-SER-LEU, CHLORIDE ION, ...
Authors:van den Oetelaar, M.C.M, Ottmann, C.
Deposit date:2022-12-22
Release date:2023-11-01
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A simple method for developing lysine targeted covalent protein reagents.
Nat Commun, 14, 2023
8C2F
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BU of 8c2f by Molmil
Structure of 14-3-3 sigma delta C with electrophilic peptide 3MHR-5
Descriptor: 14-3-3 protein sigma, ARG-ALA-HIS-SEP-CYS-PRO-ALA-SER-LEU-GLN, CHLORIDE ION, ...
Authors:van den Oetelaar, M.C.M, Ottmann, C.
Deposit date:2022-12-22
Release date:2023-11-01
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A simple method for developing lysine targeted covalent protein reagents.
Nat Commun, 14, 2023
8C5L
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BU of 8c5l by Molmil
NR2F6 ligand binding domain in complex with NSD1 peptide
Descriptor: Histone-lysine N-methyltransferase, H3 lysine-36 specific, Maltose/maltodextrin-binding periplasmic protein,Nuclear receptor subfamily 2 group F member 6, ...
Authors:Oerlemans, G.J.M, van den Oetelaar, M.C.M, Brunsveld, L.
Deposit date:2023-01-09
Release date:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insights into coregulator recruitment to the autorepressed NR2F6 nuclear receptor
To Be Published
8Q55
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BU of 8q55 by Molmil
Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 21 (1075354)
Descriptor: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-(4-methylphenyl)sulfonylpiperidin-4-yl]methyl]ethanamide, C-RAF peptide pS259, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2023-08-08
Release date:2025-02-19
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
8Q5C
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BU of 8q5c by Molmil
Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 12 (1075475)
Descriptor: 14-3-3 protein sigma, C-RAF peptide pS259, CHLORIDE ION, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2023-08-08
Release date:2025-02-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
9F35
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BU of 9f35 by Molmil
Co-crystal structure of 14-3-3sigma in complex with B-Raf pS365 phosphopeptide
Descriptor: 14-3-3 protein sigma, Serine/threonine-protein kinase B-raf
Authors:Wu, Q.
Deposit date:2024-04-24
Release date:2025-02-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Proximity-enhanced cysteine-histidine crosslinking for elucidating intrinsically disordered and other protein complexes.
Chem Sci, 2025

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數據於2025-02-19公開中

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