3HCN
 
 | | Hg and protoporphyrin bound Human Ferrochelatase | | Descriptor: | BICARBONATE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | | Authors: | Medlock, A.E, Dailey, H.A, Lanzilotta, W.N. | | Deposit date: | 2009-05-06 | | Release date: | 2009-11-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Product release rather than chelation determines metal specificity for ferrochelatase.
J.Mol.Biol., 393, 2009
|
|
3HCP
 | | Human ferrochelatase with Mn and deuteroporphyrin bound | | Descriptor: | CHOLIC ACID, FE(III) DEUTEROPORPHYRIN IX, FE2/S2 (INORGANIC) CLUSTER, ... | | Authors: | Medlock, A.E, Dailey, H.A, Lanzilotta, W.N. | | Deposit date: | 2009-05-06 | | Release date: | 2009-11-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Product release rather than chelation determines metal specificity for ferrochelatase.
J.Mol.Biol., 393, 2009
|
|
3HCO
 | | Human ferrochelatase with Cd and protoporphyrin IX bound | | Descriptor: | BICARBONATE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | | Authors: | Medlock, A.E, Dailey, H.A, Lanzilotta, W.N. | | Deposit date: | 2009-05-06 | | Release date: | 2009-11-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Product release rather than chelation determines metal specificity for ferrochelatase.
J.Mol.Biol., 393, 2009
|
|
3HCR
 | | Human Ferrochelatase with deuteroporphyrin and Ni Bound | | Descriptor: | CHLORIDE ION, CHOLIC ACID, FE(III) DEUTEROPORPHYRIN IX, ... | | Authors: | Medlock, A.E, Dailey, H.A, Lanzilotta, W.N. | | Deposit date: | 2009-05-06 | | Release date: | 2009-11-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Product release rather than chelation determines metal specificity for ferrochelatase.
J.Mol.Biol., 393, 2009
|
|
2QD3
 | | Wild type human ferrochelatase crystallized with ammonium sulfate | | Descriptor: | CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | Authors: | Medlock, A.E, Dailey, T.A, Ross, T.A, Dailey, H.A, Lanzilotta, W.N. | | Deposit date: | 2007-06-20 | | Release date: | 2007-10-30 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | A pi-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase.
J.Mol.Biol., 373, 2007
|
|
2QD2
 | | F110A variant of human ferrochelatase with protoheme bound | | Descriptor: | BICARBONATE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | | Authors: | Medlock, A.E, Dailey, T.A, Ross, T.A, Dailey, H.A, Lanzilota, W.N. | | Deposit date: | 2007-06-20 | | Release date: | 2007-10-30 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | A pi-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase.
J.Mol.Biol., 373, 2007
|
|
2QD4
 | | Wild type human ferrochelatase crystallized with MnCl2 | | Descriptor: | CHLORIDE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | | Authors: | Medlock, A.E, Dailey, T.A, Ross, T.A, Dailey, H.A, Lanzilotta, W.N. | | Deposit date: | 2007-06-20 | | Release date: | 2007-10-30 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A pi-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase.
J.Mol.Biol., 373, 2007
|
|
2QD1
 | | 2.2 Angstrom Structure of the human ferrochelatase variant E343K with substrate bound | | Descriptor: | CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | Authors: | Medlock, A.E, Dailey, T.A, Ross, T.A, Dailey, H.A, Lanzilotta, W.N. | | Deposit date: | 2007-06-20 | | Release date: | 2007-10-30 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | A pi-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase.
J.Mol.Biol., 373, 2007
|
|
3AQI
 | | H240A variant of human ferrochelatase | | Descriptor: | CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | Authors: | Lanzilotta, W.N, Medlock, A.E, Dailey, T.A, Dailey, H.A. | | Deposit date: | 2010-11-03 | | Release date: | 2012-01-25 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | H240A variant of human ferrochelatase
To be published
|
|
7L78
 | | H235C variant of Yeast Ferrochelatase | | Descriptor: | CHOLIC ACID, Ferrochelatase, mitochondrial | | Authors: | Lanzilotta, W.N, Medlock, A.E. | | Deposit date: | 2020-12-27 | | Release date: | 2021-11-24 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase.
Redox Biol, 46, 2021
|
|
2PNJ
 | | Crystal structure of human ferrochelatase mutant with Phe 337 replaced by Ala | | Descriptor: | CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | Authors: | Dailey, H.A, Wu, C.-K, Horanyi, P, Medlock, A.E, Najahi-Missaoui, W, Burden, A.E, Dailey, T.A, Rose, J.P. | | Deposit date: | 2007-04-24 | | Release date: | 2007-10-02 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis
Biochemistry, 46, 2007
|
|
2PO5
 | | Crystal structure of human ferrochelatase mutant with His 263 replaced by Cys | | Descriptor: | CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | Authors: | Dailey, H.A, Wu, C.-K, Horanyi, P, Medlock, A.E, Najahi-Missaoui, A.E.W, Burden, A, Dailey, T.A, Rose, J.P. | | Deposit date: | 2007-04-25 | | Release date: | 2007-10-02 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis
Biochemistry, 46, 2007
|
|
2PO7
 | | Crystal structure of human ferrochelatase mutant with His 341 replaced by Cys | | Descriptor: | CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | Authors: | Dailey, H.A, Wu, C.-K, Horanyi, P, Medlock, A.E, Najahi-Missaoui, W, Burden, A, Dailey, T.A, Rose, J.P. | | Deposit date: | 2007-04-25 | | Release date: | 2007-10-02 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis.
Biochemistry, 46, 2007
|
|
4KLA
 | |
4MK4
 | | S197C variant of human ferrochelatase. | | Descriptor: | CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | Authors: | Lanzilotta, W.N, Medlock, A.E, Dailey, T.E, Dailey, H.A. | | Deposit date: | 2013-09-04 | | Release date: | 2013-09-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | S197C variant of human ferrochelatase.
To be Published
|
|
4KMM
 | |
4KLR
 | |
4KLC
 | |
4F4D
 | | F337R variant of human ferrochelatase | | Descriptor: | CHLORIDE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | | Authors: | Lanzilotta, W.N, Medlock, A.E, Dailey, T.E, Dailey, H.A. | | Deposit date: | 2012-05-10 | | Release date: | 2012-09-12 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | F337R Variant of Human Ferrochelatase
TO BE PUBLISHED
|
|
2QD5
 | | Structure of wild type human ferrochelatase in complex with a lead-porphyrin compound | | Descriptor: | ACETIC ACID, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | | Authors: | Meldock, A.E, Dailey, T.A, Ross, T.A, Dailey, H.A, Lanzilotta, W.N. | | Deposit date: | 2007-06-20 | | Release date: | 2007-10-30 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A pi-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase.
J.Mol.Biol., 373, 2007
|
|
