4JTA
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![BU of 4jta by Molmil](/molmil-images/mine/4jta) | Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ... | Authors: | MacKinnon, R, Banerjee, A, Lee, A, Campbell, E. | Deposit date: | 2013-03-23 | Release date: | 2013-06-12 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel. Elife, 2, 2013
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6V00
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![BU of 6v00 by Molmil](/molmil-images/mine/6v00) | structure of human KCNQ1-KCNE3-CaM complex | Descriptor: | CALCIUM ION, Calmodulin-1, MCherry fluorescent protein,Potassium voltage-gated channel subfamily E member 3, ... | Authors: | Mackinnon, R, Sun, J. | Deposit date: | 2019-11-16 | Release date: | 2019-12-04 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural Basis of Human KCNQ1 Modulation and Gating. Cell, 180, 2020
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6UZZ
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![BU of 6uzz by Molmil](/molmil-images/mine/6uzz) | structure of human KCNQ1-CaM complex | Descriptor: | CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1 | Authors: | Mackinnon, R, Sun, J. | Deposit date: | 2019-11-16 | Release date: | 2019-12-04 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural Basis of Human KCNQ1 Modulation and Gating. Cell, 180, 2020
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6V01
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![BU of 6v01 by Molmil](/molmil-images/mine/6v01) | structure of human KCNQ1-KCNE3-CaM complex with PIP2 | Descriptor: | CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily E member 3, ... | Authors: | Mackinnon, R, Sun, J. | Deposit date: | 2019-11-18 | Release date: | 2019-12-04 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural Basis of Human KCNQ1 Modulation and Gating. Cell, 180, 2020
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5TJ6
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![BU of 5tj6 by Molmil](/molmil-images/mine/5tj6) | Ca2+ bound aplysia Slo1 | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, High conductance calcium-activated potassium channel, ... | Authors: | MacKinnon, R, Tao, X, Hite, R.K. | Deposit date: | 2016-10-03 | Release date: | 2016-12-14 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structure of the open high-conductance Ca(2+)-activated K(+) channel. Nature, 541, 2017
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5TJI
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![BU of 5tji by Molmil](/molmil-images/mine/5tji) | Ca2+ bound aplysia Slo1 | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, High conductance calcium-activated potassium channel | Authors: | MacKinnon, R, Tao, X, Hite, R.K. | Deposit date: | 2016-10-04 | Release date: | 2016-12-28 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis for gating the high-conductance Ca(2+)-activated K(+) channel. Nature, 541, 2017
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5VMS
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![BU of 5vms by Molmil](/molmil-images/mine/5vms) | CryoEM structure of Xenopus KCNQ1 channel | Descriptor: | CALCIUM ION, Calmodulin, Potassium voltage-gated channel subfamily KQT member 1 | Authors: | Mackinnon, R, Sun, J. | Deposit date: | 2017-04-28 | Release date: | 2017-06-07 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome. Cell, 169, 2017
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1S5H
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![BU of 1s5h by Molmil](/molmil-images/mine/1s5h) | Potassium Channel Kcsa-Fab Complex T75C mutant in K+ | Descriptor: | ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, DIACYL GLYCEROL, ... | Authors: | Mackinnon, R, Zhou, M. | Deposit date: | 2004-01-20 | Release date: | 2004-05-18 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution. J.Mol.Biol., 338, 2004
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6CNM
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![BU of 6cnm by Molmil](/molmil-images/mine/6cnm) | Cryo-EM structure of the human SK4/calmodulin channel complex | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calmodulin-1, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Lee, C.H, MacKinnon, R. | Deposit date: | 2018-03-08 | Release date: | 2018-05-02 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures. Science, 360, 2018
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6COZ
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![BU of 6coz by Molmil](/molmil-images/mine/6coz) | |
1KPK
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![BU of 1kpk by Molmil](/molmil-images/mine/1kpk) | Crystal Structure of the ClC Chloride Channel from E. coli | Descriptor: | putative channel transporter | Authors: | Dutzler, R, Campbell, E.B, Cadene, M, Chait, B.T, MacKinnon, R. | Deposit date: | 2001-12-31 | Release date: | 2002-01-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of
anion selectivity. Nature, 415, 2002
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1KPL
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![BU of 1kpl by Molmil](/molmil-images/mine/1kpl) | Crystal Structure of the ClC Chloride Channel from S. typhimurium | Descriptor: | CHLORIDE ION, N-OCTANE, PENTADECANE, ... | Authors: | Dutzler, R, Campbell, E.B, Cadene, M, Chait, B.T, MacKinnon, R. | Deposit date: | 2001-12-31 | Release date: | 2002-01-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of
anion selectivity. Nature, 415, 2002
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2ITD
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![BU of 2itd by Molmil](/molmil-images/mine/2itd) | Potassium Channel KcsA-Fab complex in Barium Chloride | Descriptor: | BARIUM ION, Voltage-gated potassium channel, antibody Fab fragment heavy chain, ... | Authors: | Lockless, S.W, Zhou, M, MacKinnon, R. | Deposit date: | 2006-10-19 | Release date: | 2007-05-15 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural and Thermodynamic Properties of Selective Ion Binding in a K(+) Channel. Plos Biol., 5, 2007
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2ITC
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![BU of 2itc by Molmil](/molmil-images/mine/2itc) | Potassium Channel KcsA-Fab complex in Sodium Chloride | Descriptor: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, SODIUM ION, ... | Authors: | Lockless, S.W, Zhou, M, MacKinnon, R. | Deposit date: | 2006-10-19 | Release date: | 2007-05-15 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural and Thermodynamic Properties of Selective Ion Binding in a K(+) Channel. Plos Biol., 5, 2007
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2IH1
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![BU of 2ih1 by Molmil](/molmil-images/mine/2ih1) | Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, FAB Heavy Chain, FAB Light Chain, ... | Authors: | Valiyaveetil, F.I, Leonetti, M, Muir, T.W, MacKinnon, R. | Deposit date: | 2006-09-25 | Release date: | 2006-11-21 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Ion Selectivity in a Semisynthetic K+ Channel Locked in the Conductive Conformation. Science, 314, 2006
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9BQ2
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![BU of 9bq2 by Molmil](/molmil-images/mine/9bq2) | |
5K7L
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![BU of 5k7l by Molmil](/molmil-images/mine/5k7l) | |
2R9R
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![BU of 2r9r by Molmil](/molmil-images/mine/2r9r) | Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in association with beta subunit | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ... | Authors: | Long, S.B, Tao, X, Campbell, E.B, Mackinnon, R. | Deposit date: | 2007-09-13 | Release date: | 2007-11-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature, 450, 2007
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1K4C
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![BU of 1k4c by Molmil](/molmil-images/mine/1k4c) | Potassium Channel KcsA-Fab complex in high concentration of K+ | Descriptor: | DIACYL GLYCEROL, NONAN-1-OL, POTASSIUM ION, ... | Authors: | Zhou, Y, Morais-Cabral, J.H, Kaufman, A, MacKinnon, R. | Deposit date: | 2001-10-07 | Release date: | 2001-11-14 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution. Nature, 414, 2001
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1K4D
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![BU of 1k4d by Molmil](/molmil-images/mine/1k4d) | Potassium Channel KcsA-Fab complex in low concentration of K+ | Descriptor: | DIACYL GLYCEROL, NONAN-1-OL, POTASSIUM ION, ... | Authors: | Zhou, Y, Morais-Cabral, J.H, Kaufman, A, MacKinnon, R. | Deposit date: | 2001-10-07 | Release date: | 2001-11-14 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution. Nature, 414, 2001
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8UQO
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![BU of 8uqo by Molmil](/molmil-images/mine/8uqo) | PLCb3-Gbg-Gaq complex on membranes | Descriptor: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Falzone, M.E, MacKinnon, R. | Deposit date: | 2023-10-24 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | The mechanism of G alpha q regulation of PLC beta 3 -catalyzed PIP2 hydrolysis. Proc.Natl.Acad.Sci.USA, 120, 2023
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8UQN
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![BU of 8uqn by Molmil](/molmil-images/mine/8uqn) | PLCb3-Gaq complex on membranes | Descriptor: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Falzone, M.E, MacKinnon, R. | Deposit date: | 2023-10-24 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | The mechanism of G alpha q regulation of PLC beta 3 -catalyzed PIP2 hydrolysis. Proc.Natl.Acad.Sci.USA, 120, 2023
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4FG6
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![BU of 4fg6 by Molmil](/molmil-images/mine/4fg6) | Structure of EcCLC E148A mutant in Glutamate | Descriptor: | Fab fragment (Heavy chain), Fab fragment (Light chain), H(+)/Cl(-) exchange transporter ClcA | Authors: | Feng, L, MacKinnon, R. | Deposit date: | 2012-06-04 | Release date: | 2012-07-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.019 Å) | Cite: | Molecular mechanism of proton transport in CLC Cl-/H+ exchange transporters. Proc.Natl.Acad.Sci.USA, 109, 2012
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3ORG
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![BU of 3org by Molmil](/molmil-images/mine/3org) | |
4WFH
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![BU of 4wfh by Molmil](/molmil-images/mine/4wfh) | |