6LHR
 
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6LII
 | | A quinone oxidoreductase | | Descriptor: | Synaptic vesicle membrane protein VAT-1 homolog | | Authors: | Hakoshima, T, Kim, S.-Y, Mori, T. | | Deposit date: | 2019-12-11 | | Release date: | 2021-01-20 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural insights into vesicle amine transport-1 (VAT-1) as a member of the NADPH-dependent quinone oxidoreductase family.
Sci Rep, 11, 2021
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1CXZ
 | | CRYSTAL STRUCTURE OF HUMAN RHOA COMPLEXED WITH THE EFFECTOR DOMAIN OF THE PROTEIN KINASE PKN/PRK1 | | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, PROTEIN (HIS-TAGGED TRANSFORMING PROTEIN RHOA(0-181)), ... | | Authors: | Maesaki, R, Ihara, K, Shimizu, T, Kuroda, S, Kaibuchi, K, Hakoshima, T. | | Deposit date: | 1999-08-31 | | Release date: | 1999-10-08 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.
Mol.Cell, 4, 1999
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2A0B
 | | HISTIDINE-CONTAINING PHOSPHOTRANSFER DOMAIN OF ARCB FROM ESCHERICHIA COLI | | Descriptor: | HPT DOMAIN, ZINC ION | | Authors: | Kato, M, Mizuno, T, Shimizu, T, Hakoshima, T. | | Deposit date: | 1998-04-02 | | Release date: | 1998-06-17 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Refined structure of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor kinase ArcB from Escherichia coli at 1.57 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
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1NPM
 | | NEUROPSIN, A SERINE PROTEASE EXPRESSED IN THE LIMBIC SYSTEM OF MOUSE BRAIN | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, NEUROPSIN | | Authors: | Kishi, T, Kato, M, Shimizu, T, Kato, K, Matsumoto, K, Yoshida, S, Shiosaka, S, Hakoshima, T. | | Deposit date: | 1998-01-07 | | Release date: | 1999-03-23 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of neuropsin, a hippocampal protease involved in kindling epileptogenesis.
J.Biol.Chem., 274, 1999
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9KNK
 | | Crystal structure of full-length PHA synthase (PhaC) from Aeromonas caviae | | Descriptor: | PHA synthase | | Authors: | Chek, M.F, Kim, S.Y, Mori, T, Hakoshima, T. | | Deposit date: | 2024-11-19 | | Release date: | 2025-05-21 | | Last modified: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (3.29 Å) | | Cite: | Structures of Polyhydroxyalkanoate Synthase PhaC from Aeromonas caviae, Producing Biodegradable Plastics.
Angew.Chem.Int.Ed.Engl., 64, 2025
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9KNL
 | | Crystal structure of triethylene glycol-bound full-length PHA synthase (PhaC) from Aeromonas caviae | | Descriptor: | PHA synthase, TRIETHYLENE GLYCOL | | Authors: | Chek, M.F, Kim, S.Y, Mori, T, Hakoshima, T. | | Deposit date: | 2024-11-19 | | Release date: | 2025-05-21 | | Last modified: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structures of Polyhydroxyalkanoate Synthase PhaC from Aeromonas caviae, Producing Biodegradable Plastics.
Angew.Chem.Int.Ed.Engl., 64, 2025
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9KNJ
 | | Crystal structure of glycerol-bound full-length PHA synthase (PhaC) from Aeromonas caviae | | Descriptor: | GLYCEROL, PHA synthase | | Authors: | Chek, M.F, Kim, S.Y, Mori, T, Hakoshima, T. | | Deposit date: | 2024-11-19 | | Release date: | 2025-05-21 | | Last modified: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structures of Polyhydroxyalkanoate Synthase PhaC from Aeromonas caviae, Producing Biodegradable Plastics.
Angew.Chem.Int.Ed.Engl., 64, 2025
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1WPL
 | | Crystal structure of the inhibitory form of rat GTP cyclohydrolase I/GFRP complex | | Descriptor: | 7,8-DIHYDROBIOPTERIN, GTP cyclohydrolase I, GTP cyclohydrolase I feedback regulatory protein, ... | | Authors: | Maita, N, Hatakeyama, K, Okada, K, Hakoshima, T. | | Deposit date: | 2004-09-08 | | Release date: | 2004-09-28 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein
J.Biol.Chem., 279, 2004
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1DPF
 | | CRYSTAL STRUCTURE OF A MG-FREE FORM OF RHOA COMPLEXED WITH GDP | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, RHOA | | Authors: | Shimizu, T, Ihara, K, Maesaki, R, Kuroda, S, Kaibuchi, K, Hakoshima, T. | | Deposit date: | 1999-12-27 | | Release date: | 2000-06-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | An open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanism.
J.Biol.Chem., 275, 2000
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1A0B
 | | HISTIDINE-CONTAINING PHOSPHOTRANSFER DOMAIN OF ARCB FROM ESCHERICHIA COLI | | Descriptor: | AEROBIC RESPIRATION CONTROL SENSOR PROTEIN ARCB, ZINC ION | | Authors: | Kato, M, Mizuno, T, Shimizu, T, Hakoshima, T. | | Deposit date: | 1997-11-27 | | Release date: | 1998-03-18 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Insights into multistep phosphorelay from the crystal structure of the C-terminal HPt domain of ArcB.
Cell(Cambridge,Mass.), 88, 1997
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5YIZ
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5YJ0
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2RRD
 | | Structure of HRDC domain from human Bloom syndrome protein, BLM | | Descriptor: | HRDC domain from Bloom syndrome protein | | Authors: | Sato, A, Mishima, M, Nagai, A, Kim, S.Y, Ito, Y, Hakoshima, T, Jee, J.G, Kitano, K. | | Deposit date: | 2010-07-19 | | Release date: | 2010-09-08 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the HRDC domain of human Bloom syndrome protein BLM
J.Biochem., 148, 2010
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5YJ1
 | | Mouse Cereblon thalidomide binding domain complexed with R-form thalidomide | | Descriptor: | 2-[(3~{R})-2,6-bis(oxidanylidene)piperidin-3-yl]isoindole-1,3-dione, Protein cereblon, SULFATE ION, ... | | Authors: | Mori, T, Hakoshima, T. | | Deposit date: | 2017-10-06 | | Release date: | 2018-02-07 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis of thalidomide enantiomer binding to cereblon
Sci Rep, 8, 2018
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2D10
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2D11
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2YVC
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1DJ6
 | | COMPLEX OF A Z-DNA HEXAMER, D(CG)3, WITH SYNTHETIC POLYAMINE AT ROOM TEMPERATURE | | Descriptor: | 5'-D(*CP*GP*CP*GP*CP*G)-3', MAGNESIUM ION, N,N'-BIS(2-AMINOETHYL)-1,2-ETHANEDIAMINE | | Authors: | Ohishi, H, Tomita, K.-i, Nakanishi, I, Ohtsuchi, M, Hakoshima, T, Rich, A. | | Deposit date: | 1999-12-01 | | Release date: | 1999-12-18 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1 Å) | | Cite: | The crystal structure of N1-[2-(2-amino-ethylamino)-ethyl]-ethane-1,2-diamine (polyamines) binding to the minor groove of d(CGCGCG)2, hexamer at room temperature
FEBS Lett., 523, 2002
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1UJB
 | | Structure of the protein histidine phosphatase SixA | | Descriptor: | CALCIUM ION, Phosphohistidine phosphatase sixA | | Authors: | Hamada, K, Kato, M, Shimizu, T, Ihara, K, Mizuno, T, Hakoshima, T. | | Deposit date: | 2003-07-31 | | Release date: | 2005-01-25 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Crystal structure of the protein histidine phosphatase SixA in the multistep His-Asp phosphorelay.
Genes Cells, 10, 2005
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1UJC
 | | Structure of the protein histidine phosphatase SixA complexed with tungstate | | Descriptor: | CALCIUM ION, Phosphohistidine phosphatase sixA, TUNGSTATE(VI)ION | | Authors: | Hamada, K, Kato, M, Shimizu, T, Ihara, K, Mizuno, T, Hakoshima, T. | | Deposit date: | 2003-07-31 | | Release date: | 2005-01-25 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of the protein histidine phosphatase SixA in the multistep His-Asp phosphorelay.
Genes Cells, 10, 2005
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5XAV
 | | Structure of PhaC from Chromobacterium sp. USM2 | | Descriptor: | Intracellular polyhydroxyalkanoate synthase | | Authors: | Chek, M.F, Kim, S.Y, Mori, T, Arsad, H, Samian, M.R, Sudesh, K, Hakoshima, T. | | Deposit date: | 2017-03-15 | | Release date: | 2017-07-26 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.479 Å) | | Cite: | Structure of polyhydroxyalkanoate (PHA) synthase PhaC from Chromobacterium sp. USM2, producing biodegradable plastics
Sci Rep, 7, 2017
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1GC6
 | | CRYSTAL STRUCTURE OF THE RADIXIN FERM DOMAIN COMPLEXED WITH INOSITOL-(1,4,5)-TRIPHOSPHATE | | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, RADIXIN | | Authors: | Hamada, K, Shimizu, T, Matsui, T, Tsukita, S, Tsukita, S, Hakoshima, T. | | Deposit date: | 2000-07-21 | | Release date: | 2000-09-20 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain.
EMBO J., 19, 2000
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1GD2
 | | CRYSTAL STRUCTURE OF BZIP TRANSCRIPTION FACTOR PAP1 BOUND TO DNA | | Descriptor: | DNA (5'-D(*AP*GP*GP*TP*TP*AP*CP*GP*TP*AP*AP*CP*C)-3'), TRANSCRIPTION FACTOR PAP1 | | Authors: | Fujii, Y, Shimizu, T, Toda, T, Yanagida, M, Hakoshima, T. | | Deposit date: | 2000-08-25 | | Release date: | 2000-10-02 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for the diversity of DNA recognition by bZIP transcription factors.
Nat.Struct.Biol., 7, 2000
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1GC7
 | | CRYSTAL STRUCTURE OF THE RADIXIN FERM DOMAIN | | Descriptor: | RADIXIN | | Authors: | Hamada, K, Shimizu, T, Matsui, T, Tsukita, S, Tsukita, S, Hakoshima, T. | | Deposit date: | 2000-07-21 | | Release date: | 2000-09-20 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain.
EMBO J., 19, 2000
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