5YIZ

Mouse Cereblon thalidomide binding domain complexed with racemic thalidomide

Summary for 5YIZ

• Entry DOI: 10.2210/pdb5yiz/pdb
• Related: 3WX2
• Descriptor: Protein cereblon, S-Thalidomide, ZINC ION, ... (5 entities in total)
• Functional Keywords: zinc binding protein, metal binding protein
• Biological source: Mus musculus (Mouse)
• Cellular location: Cytoplasm : Q8C7D2
• Total number of polymer chains: 16
• Total formula weight: 205424.43

Authors

Mori, T.,Hakoshima, T. (deposition date: 2017-10-06, release date: 2018-02-07, Last modification date: 2023-11-22)

• Primary citation: Mori, T.,Ito, T.,Liu, S.,Ando, H.,Sakamoto, S.,Yamaguchi, Y.,Tokunaga, E.,Shibata, N.,Handa, H.,Hakoshima, T.; Structural basis of thalidomide enantiomer binding to cereblon; Sci Rep, 8:1294-1294, 2018; PubMed: 29358579; DOI: 10.1038/s41598-018-19202-7

Experimental method

X-RAY DIFFRACTION (2 Å)