4R1E
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![BU of 4r1e by Molmil](/molmil-images/mine/4r1e) | Crystal Structure of MTIP from Plasmodium falciparum in complex with a peptide-fragment chimera | Descriptor: | 5-{[(2-aminoethyl)sulfanyl]methyl}furan-2-carbaldehyde, Myosin A tail domain interacting protein, Myosin-A | Authors: | Douse, C.H, Vrielink, N, Cota, E, Tate, E.W. | Deposit date: | 2014-08-05 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Targeting a Dynamic Protein-Protein Interaction: Fragment Screening against the Malaria Myosin A Motor Complex. Chemmedchem, 10, 2015
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6TL1
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![BU of 6tl1 by Molmil](/molmil-images/mine/6tl1) | Crystal structure of the TASOR pseudo-PARP domain | Descriptor: | GLYCEROL, Protein TASOR | Authors: | Douse, C.H, Timms, R.T, Freund, S.M.V, Modis, Y. | Deposit date: | 2019-11-29 | Release date: | 2020-09-16 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control. Nat Commun, 11, 2020
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4MZJ
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![BU of 4mzj by Molmil](/molmil-images/mine/4mzj) | Crystal Structure of MTIP from Plasmodium falciparum in complex with pGly[801,805], a stapled myoA tail peptide | Descriptor: | Myosin A tail domain interacting protein, Myosin-A | Authors: | Douse, C.H, Garnett, J.A, Maas, S.J, Cota, E, Tate, E.W. | Deposit date: | 2013-09-30 | Release date: | 2013-11-06 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.474 Å) | Cite: | Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein-Helix Interaction. Acs Chem.Biol., 8, 2014
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4MZK
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![BU of 4mzk by Molmil](/molmil-images/mine/4mzk) | Crystal Structure of MTIP from Plasmodium falciparum in complex with pGly[807,811], a stapled myoA tail peptide | Descriptor: | Myosin A tail domain interacting protein, pGly[807,811], a stapled myoA tail peptide | Authors: | Douse, C.H, Garnett, J.A, Maas, S.J, Cota, E, Tate, E.W. | Deposit date: | 2013-09-30 | Release date: | 2013-11-06 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein-Helix Interaction. Acs Chem.Biol., 8, 2014
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4MZL
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![BU of 4mzl by Molmil](/molmil-images/mine/4mzl) | Crystal Structure of MTIP from Plasmodium falciparum in complex with HBS myoA, a hydrogen bond surrogate myoA helix mimetic | Descriptor: | Myosin A tail domain interacting protein, hydrogen bond surrogate (HBS) myoA helix mimetic | Authors: | Douse, C.H, Garnett, J.A, Maas, S.J, Cota, E, Tate, E.W. | Deposit date: | 2013-09-30 | Release date: | 2013-11-06 | Last modified: | 2023-06-07 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein-Helix Interaction. Acs Chem.Biol., 8, 2014
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5OFB
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![BU of 5ofb by Molmil](/molmil-images/mine/5ofb) | Crystal structure of human MORC2 (residues 1-603) with spinal muscular atrophy mutation S87L | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, MORC family CW-type zinc finger protein 2, ... | Authors: | Douse, C.H, Liu, Y, Modis, Y. | Deposit date: | 2017-07-10 | Release date: | 2018-02-14 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms. Nat Commun, 9, 2018
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5OF9
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![BU of 5of9 by Molmil](/molmil-images/mine/5of9) | Crystal structure of human MORC2 (residues 1-603) | Descriptor: | MAGNESIUM ION, MORC family CW-type zinc finger protein 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Douse, C.H, Shamin, M, Modis, Y. | Deposit date: | 2017-07-10 | Release date: | 2018-02-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.807 Å) | Cite: | Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms. Nat Commun, 9, 2018
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5OFA
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![BU of 5ofa by Molmil](/molmil-images/mine/5ofa) | Crystal structure of human MORC2 (residues 1-603) with spinal muscular atrophy mutation T424R | Descriptor: | MAGNESIUM ION, MORC family CW-type zinc finger protein 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Douse, C.H, Liu, Y, Modis, Y. | Deposit date: | 2017-07-10 | Release date: | 2018-02-14 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms. Nat Commun, 9, 2018
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4AOM
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![BU of 4aom by Molmil](/molmil-images/mine/4aom) | MTIP and MyoA complex | Descriptor: | MYOSIN A TAIL DOMAIN INTERACTING PROTEIN, MYOSIN-A | Authors: | Salgado, P.S, Douse, C.H, Simpson, P.J, Thomas, J.C, Holder, A.A, Tate, E.W, Cota, E. | Deposit date: | 2012-03-29 | Release date: | 2012-09-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.939 Å) | Cite: | Regulation of the Plasmodium Motor Complex: Phosphorylation of Myosin a Tail Interacting Protein (Mtip) Loosens its Grip on Myoa J.Biol.Chem., 287, 2012
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7Z36
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![BU of 7z36 by Molmil](/molmil-images/mine/7z36) | Crystal structure of the KAP1 tripartite motif in complex with the ZNF93 KRAB domain | Descriptor: | Endolysin,Transcription intermediary factor 1-beta,Isoform 2 of Transcription intermediary factor 1-beta, SMARCAD1 CUE1 domain, ZINC ION, ... | Authors: | Stoll, G.A, Modis, Y. | Deposit date: | 2022-03-01 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure and functional mapping of the KRAB-KAP1 repressor complex. Embo J., 41, 2022
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8P0C
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![BU of 8p0c by Molmil](/molmil-images/mine/8p0c) | Rubella virus p150 macro domain (apo) | Descriptor: | Non-structural polyprotein p200 | Authors: | Stoll, G.A, Modis, Y. | Deposit date: | 2023-05-10 | Release date: | 2024-01-17 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Crystal structure and biochemical activity of the macrodomain from rubella virus p150. J.Virol., 98, 2024
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8P0E
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![BU of 8p0e by Molmil](/molmil-images/mine/8p0e) | |
6SWG
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![BU of 6swg by Molmil](/molmil-images/mine/6swg) | |
2MHJ
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![BU of 2mhj by Molmil](/molmil-images/mine/2mhj) | |