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7ZAU
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BU of 7zau by Molmil
Fascin-1 in complex with Nb 3E11
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Fascin, ...
Authors:Burgess, S.G, Bayliss, R.
Deposit date:2022-03-22
Release date:2023-09-27
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A nanobody inhibitor of Fascin-1 actin-bundling activity and filopodia formation.
Open Biology, 14, 2024
5L8J
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BU of 5l8j by Molmil
Aurora-A kinase domain in complex with vNAR-D01 S93R
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:Burgess, S.G, Bayliss, R.
Deposit date:2016-06-08
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain.
Open Biology, 6, 2016
5L8L
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BU of 5l8l by Molmil
Aurora-A kinase domain in complex with vNAR-D01 (crystal form 1)
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:Burgess, S.G, Bayliss, R.
Deposit date:2016-06-08
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain.
Open Biology, 6, 2016
5L8K
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BU of 5l8k by Molmil
Aurora-A kinase domain in complex with vNAR-D01 (crystal form 2)
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:Burgess, S.G, Bayliss, R.
Deposit date:2016-06-08
Release date:2016-07-20
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain.
Open Biology, 6, 2016
4CEG
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BU of 4ceg by Molmil
Crystal structure of Aurora A 122-403 C290A, C393A bound to ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, AURORA KINASE A, CHLORIDE ION, ...
Authors:Burgess, S.G, Bayliss, R.
Deposit date:2013-11-11
Release date:2015-01-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Structure of C290A:C393A Aurora a Provides Structural Insights Into Kinase Regulation.
Acta Crystallogr.,Sect.F, 71, 2015
5ODT
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BU of 5odt by Molmil
Aurora-A in complex with TACC3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, GLYCEROL, ...
Authors:Burgess, S.G, Bayliss, R.
Deposit date:2017-07-06
Release date:2018-03-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.021 Å)
Cite:Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic alpha-helix.
EMBO J., 37, 2018
6I2U
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BU of 6i2u by Molmil
Aurora-A kinase domain in complex with Coenzyme A
Descriptor: Aurora kinase A, COENZYME A, DI(HYDROXYETHYL)ETHER, ...
Authors:Burgess, S.G, Bayliss, R.
Deposit date:2018-11-02
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Covalent Aurora A regulation by the metabolic integrator coenzyme A.
Redox Biol, 28, 2019
5ORL
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BU of 5orl by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, CHLORIDE ION, ...
Authors:McIntyre, P.J, Collins, P.M, Vrzal, L, Birchall, K, Arnold, L.H, Mpamhanga, C, Coombs, P.J, Burgess, S.G, Richards, M.W, Winter, A, Veverka, V, von Delft, F, Merritt, A, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
3CLR
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BU of 3clr by Molmil
Crystal structure of the R236A ETF mutant from M. methylotrophus
Descriptor: ADENOSINE MONOPHOSPHATE, Electron transfer flavoprotein subunit alpha, Electron transfer flavoprotein subunit beta, ...
Authors:Katona, G, Leys, D.
Deposit date:2008-03-20
Release date:2008-04-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Probing the dynamic interface between trimethylamine dehydrogenase (TMADH) and electron transferring flavoprotein (ETF) in the TMADH-2ETF complex: role of the Arg-alpha237 (ETF) and Tyr-442 (TMADH) residue pair.
Biochemistry, 47, 2008
3CLU
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BU of 3clu by Molmil
Crystal structure of the R236K mutant from Methylophilus methylotrophus ETF
Descriptor: ADENOSINE MONOPHOSPHATE, Electron transfer flavoprotein subunit alpha, Electron transfer flavoprotein subunit beta, ...
Authors:Katona, G, Leys, D.
Deposit date:2008-03-20
Release date:2008-04-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Probing the dynamic interface between trimethylamine dehydrogenase (TMADH) and electron transferring flavoprotein (ETF) in the TMADH-2ETF complex: role of the Arg-alpha237 (ETF) and Tyr-442 (TMADH) residue pair.
Biochemistry, 47, 2008
3CLS
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BU of 3cls by Molmil
Crystal structure of the R236C mutant of ETF from Methylophilus methylotrophus
Descriptor: ADENOSINE MONOPHOSPHATE, Electron transfer flavoprotein subunit alpha, Electron transfer flavoprotein subunit beta, ...
Authors:Katona, G, Leys, D.
Deposit date:2008-03-20
Release date:2008-04-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Probing the dynamic interface between trimethylamine dehydrogenase (TMADH) and electron transferring flavoprotein (ETF) in the TMADH-2ETF complex: role of the Arg-alpha237 (ETF) and Tyr-442 (TMADH) residue pair.
Biochemistry, 47, 2008
3CLT
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BU of 3clt by Molmil
Crystal structure of the R236E mutant of Methylophilus methylotrophus ETF
Descriptor: ADENOSINE MONOPHOSPHATE, Electron transfer flavoprotein subunit alpha, Electron transfer flavoprotein subunit beta, ...
Authors:Katona, G, Leys, D.
Deposit date:2008-03-20
Release date:2008-04-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Probing the dynamic interface between trimethylamine dehydrogenase (TMADH) and electron transferring flavoprotein (ETF) in the TMADH-2ETF complex: role of the Arg-alpha237 (ETF) and Tyr-442 (TMADH) residue pair.
Biochemistry, 47, 2008
5G1X
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BU of 5g1x by Molmil
Crystal structure of Aurora-A kinase in complex with N-Myc
Descriptor: ADENOSINE-5'-DIPHOSPHATE, AURORA KINASE A, MAGNESIUM ION, ...
Authors:Richards, M.W, Burgess, S.G, Bayliss, R.
Deposit date:2016-03-31
Release date:2016-11-16
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural Basis of N-Myc Binding by Aurora-A and its Destabilization by Kinase Inhibitors
Proc.Natl.Acad.Sci.USA, 113, 2016
5DE2
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BU of 5de2 by Molmil
Structural mechanism of Nek7 activation by Nek9-induced dimerisation
Descriptor: Serine/threonine-protein kinase Nek7, Serine/threonine-protein kinase Nek9
Authors:Haq, T, Bayliss, R.
Deposit date:2015-08-25
Release date:2015-11-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization.
Nat Commun, 6, 2015
5ORO
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BU of 5oro by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: 3-(4-chlorophenyl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORR
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BU of 5orr by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: 4-[4-(trifluoromethyl)phenyl]-1,2,3-thiadiazol-5-amine, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5OS0
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BU of 5os0 by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: 2-[4-(3-chlorophenyl)piperazin-1-ium-1-yl]ethanenitrile, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORN
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BU of 5orn by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: 3-thiophen-2-yl-4,5-dihydro-1~{H}-pyridazin-6-one, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORT
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BU of 5ort by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, CHLORIDE ION, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5OS2
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BU of 5os2 by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, MAGNESIUM ION, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORZ
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BU of 5orz by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, CHLORIDE ION, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5OSE
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BU of 5ose by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, MAGNESIUM ION, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-17
Release date:2017-11-01
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORV
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BU of 5orv by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, CHLORIDE ION, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5OS3
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BU of 5os3 by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: (1~{R})-1-(4-ethoxyphenyl)ethanamine, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5OS4
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BU of 5os4 by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: (3~{a}~{R},5~{S},7~{a}~{S})-5-phenyl-3~{a},4,5,6,7,7~{a}-hexahydroisoindole-1,3-dione, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017

 

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數據於2024-10-30公開中

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