5L8L

Aurora-A kinase domain in complex with vNAR-D01 (crystal form 1)

Summary for 5L8L

• Entry DOI: 10.2210/pdb5l8l/pdb
• Descriptor: Aurora kinase A, New antigen receptor variable domain, ADENOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: kinase, vnar, inhibitor, transferase
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
• Total number of polymer chains: 2
• Total formula weight: 47140.81

Authors

Burgess, S.G.,Bayliss, R. (deposition date: 2016-06-08, release date: 2016-07-20, Last modification date: 2024-01-10)

• Primary citation: Burgess, S.G.,Oleksy, A.,Cavazza, T.,Richards, M.W.,Vernos, I.,Matthews, D.,Bayliss, R.; Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain.; Open Biology, 6:-, 2016; PubMed: 27411893; DOI: 10.1098/rsob.160089

Experimental method

X-RAY DIFFRACTION (1.67 Å)