5L8L

Aurora-A kinase domain in complex with vNAR-D01 (crystal form 1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000212	biological_process	meiotic spindle organization
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007052	biological_process	mitotic spindle organization
A	0007098	biological_process	centrosome cycle
A	0007100	biological_process	mitotic centrosome separation
A	0051321	biological_process	meiotic cell cycle
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0042101	cellular_component	T cell receptor complex
B	0042605	molecular_function	peptide antigen binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue ADP A 501

Chain	Residue
A	LEU139
A	ALA213
A	LEU263
A	HOH602
A	HOH615
A	HOH631
A	HOH675
A	HOH712
A	HOH720
A	GLY140
A	LYS141
A	GLY142
A	LYS143
A	VAL147
A	ALA160
A	LYS162
A	GLU211

---

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 502

Chain	Residue
A	SER278
A	VAL279
A	HIS280
A	SER283
A	ARG285

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 503

Chain	Residue
A	ARG220
A	LYS224
A	ASN367
A	HOH613

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 A 504

Chain	Residue
A	TYR246
A	LYS250
A	HOH608
A	HOH614
A	HOH618
A	HOH670

---

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 A 505

Chain	Residue
A	SER266
A	LYS339
A	ARG343
A	HOH744

---

site_id	AC6
Number of Residues	8
Details	binding site for residue SO4 A 506

Chain	Residue
A	ARG151
A	GLU330
A	GLU336
A	ARG340
A	SO4507
A	HOH660
A	HOH662
B	LYS104

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 A 507

Chain	Residue
A	ARG151
A	LYS156
A	SO4506

---

site_id	AC8
Number of Residues	2
Details	binding site for residue EDO A 508

Chain	Residue
A	ARG251
A	HOH809

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO A 509

Chain	Residue
A	MET373
A	LEU374
A	ARG375
A	HOH653
A	HOH684

---

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO A 510

Chain	Residue
A	LEU130
A	PHE133
A	ASP350
A	HOH605
A	HOH630

---

site_id	AD2
Number of Residues	5
Details	binding site for residue SO4 B 201

Chain	Residue
B	MET1
B	ALA2
B	LEU92
B	ARG94
B	HOH328

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO B 202

Chain	Residue
B	SER93
B	ARG94
B	GLU95
B	HOH307

---

site_id	AD4
Number of Residues	3
Details	binding site for residue EDO B 203

Chain	Residue
B	ARG9
B	ILE10
B	HOH314

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGKFGNVYlArekqskfi..........LALK

Chain	Residue	Details
A	LEU139-LYS162

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKpeNLLL

Chain	Residue	Details
A	VAL252-LEU264

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14580337","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27837025","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G1X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"14580337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19668197","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"11039908","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"13678582","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14580337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16246726","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18662907","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19668197","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26246606","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKA and PAK","evidences":[{"source":"PubMed","id":"16246726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---