5ORO

Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment

Summary for 5ORO

Entry DOI	10.2210/pdb5oro/pdb
Descriptor	Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	kinase, allosteric inhibitor, fragment, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	31510.77
Authors	McIntyre, P.J.,Collins, P.M.,von Delft, F.,Bayliss, R. (deposition date: 2017-08-16, release date: 2017-11-01, Last modification date: 2019-10-16)
Primary citation	McIntyre, P.J.,Collins, P.M.,Vrzal, L.,Birchall, K.,Arnold, L.H.,Mpamhanga, C.,Coombs, P.J.,Burgess, S.G.,Richards, M.W.,Winter, A.,Veverka, V.,Delft, F.V.,Merritt, A.,Bayliss, R. Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches. ACS Chem. Biol., 12:2906-2914, 2017 Cited by PubMed: 29045126 DOI: 10.1021/acschembio.7b00537 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.12 Å)

Structure validation