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1CHM
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BU of 1chm by Molmil
ENZYMATIC MECHANISM OF CREATINE AMIDINOHYDROLASE AS DEDUCED FROM CRYSTAL STRUCTURES
Descriptor: CARBAMOYL SARCOSINE, CREATINE AMIDINOHYDROLASE
Authors:Hoeffken, H.W, Knof, S.H, Bartlett, P.A, Huber, R, Moellering, H, Schumacher, G.
Deposit date:1993-07-19
Release date:1994-04-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Enzymatic mechanism of creatine amidinohydrolase as deduced from crystal structures.
J.Mol.Biol., 214, 1990
6YL4
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BU of 6yl4 by Molmil
Soluble epoxide hydrolase in complex with 3-((R)-3-(1-hydroxyureido)but-1-yn-1-yl)-N-((S)-3-phenyl-3-(4-trifluoromethoxy)phenyl)propyl)benzamide
Descriptor: 3-[(3~{R})-3-[aminocarbonyl(oxidanyl)amino]but-1-ynyl]-~{N}-[(3~{S})-3-phenyl-3-[4-(trifluoromethyloxy)phenyl]propyl]benzamide, Bifunctional epoxide hydrolase 2
Authors:Kramer, J.S, Pogoryelov, D, Hiesinger, K, Proschak, E.
Deposit date:2020-04-06
Release date:2020-10-21
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase.
J.Med.Chem., 63, 2020
2IDF
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BU of 2idf by Molmil
P. aeruginosa azurin N42C/M64E double mutant, BMME-linked dimer
Descriptor: 1-[PYRROL-1-YL-2,5-DIONE-METHOXYMETHYL]-PYRROLE-2,5-DIONE, Azurin, COPPER (II) ION, ...
Authors:Einsle, O, de Jongh, T.E, Hoffmann, M, Cavazzini, D, Rossi, G.L, Ubbink, M, Canters, G.W.
Deposit date:2006-09-15
Release date:2008-03-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Electron transfer in a crosslinked protein dimer mediated by a hydrogen-bonded network across the dimer interface
To be Published
2E81
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BU of 2e81 by Molmil
Cytochrome c Nitrite Reductase from Wolinella succinogenes with bound intermediate hydroxylamine
Descriptor: CALCIUM ION, Cytochrome c-552, HYDROXYAMINE, ...
Authors:Einsle, O, Kroneck, P.M.H.
Deposit date:2007-01-15
Release date:2007-01-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanism of the six-electron reduction of nitrite to ammonia by cytochrome c nitrite reductase
J.Am.Chem.Soc., 124, 2002
2E80
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BU of 2e80 by Molmil
Cytochrome c Nitrite Reductase from Wolinella succinogenes with bound substrate nitrite
Descriptor: ACETATE ION, CALCIUM ION, Cytochrome c-552, ...
Authors:Einsle, O, Kroneck, P.M.H.
Deposit date:2007-01-15
Release date:2007-01-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mechanism of the six-electron reduction of nitrite to ammonia by cytochrome c nitrite reductase
J.Am.Chem.Soc., 124, 2002
2FT8
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BU of 2ft8 by Molmil
Structure of Cu(I)azurin, pH8, with the metal-binding loop sequence "CTFPGHSALM" replaced with "CTPHPM"
Descriptor: Azurin, COPPER (I) ION
Authors:Banfield, M.J.
Deposit date:2006-01-24
Release date:2006-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Basic requirements for a metal-binding site in a protein: The influence of loop shortening on the cupredoxin azurin.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2FT6
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BU of 2ft6 by Molmil
Structure of Cu(II)azurin with the metal-binding loop sequence "CTFPGHSALM" replaced with "CTPHPM"
Descriptor: Azurin, COPPER (II) ION
Authors:Banfield, M.J.
Deposit date:2006-01-24
Release date:2006-04-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Basic requirements for a metal-binding site in a protein: The influence of loop shortening on the cupredoxin azurin.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2FT7
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BU of 2ft7 by Molmil
Structure of Cu(I)azurin at pH 6, with the metal-binding loop sequence "CTFPGHSALM" replaced with "CTPHPM"
Descriptor: Azurin, COPPER (I) ION
Authors:Banfield, M.J.
Deposit date:2006-01-24
Release date:2006-04-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Basic requirements for a metal-binding site in a protein: The influence of loop shortening on the cupredoxin azurin.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2FTA
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BU of 2fta by Molmil
Structure of Cu(II)azurin with the metal-binding loop sequence "CTFPGHSALM" replaced with "CTPHPFM"
Descriptor: Azurin, COPPER (II) ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Banfield, M.J.
Deposit date:2006-01-24
Release date:2006-04-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Basic requirements for a metal-binding site in a protein: The influence of loop shortening on the cupredoxin azurin.
Proc.Natl.Acad.Sci.Usa, 103, 2006
8RYS
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BU of 8rys by Molmil
Human IL-1beta, unliganded
Descriptor: Interleukin-1 beta, SULFATE ION
Authors:Rondeau, J.-M, Lehmann, S.
Deposit date:2024-02-09
Release date:2024-03-06
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Ligandability Assessment of IL-1 beta by Integrated Hit Identification Approaches.
J.Med.Chem., 67, 2024
8RYK
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BU of 8ryk by Molmil
IL-1beta in complex with macrocyclic peptide hit
Descriptor: Interleukin-1 beta, Macrocyclic peptide
Authors:Rondeau, J.-M, Lehmann, S.
Deposit date:2024-02-09
Release date:2024-05-22
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ligandability Assessment of IL-1 beta by Integrated Hit Identification Approaches.
J.Med.Chem., 67, 2024
8RZB
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BU of 8rzb by Molmil
IL-1beta in complex with covalent DEL hit
Descriptor: 8-[4-methyl-3-(trifluoromethyl)phenyl]-2-[[(7S)-7-(2-morpholin-4-ylethylcarbamoyl)-4-(phenylsulfonyl)-1,4-diazepan-1-yl]carbonyl]imidazo[1,2-a]pyridine-6-carboxylic acid, Interleukin-1 beta
Authors:Rondeau, J.-M, Lehmann, S.
Deposit date:2024-02-12
Release date:2024-05-22
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.836 Å)
Cite:Ligandability Assessment of IL-1 beta by Integrated Hit Identification Approaches.
J.Med.Chem., 67, 2024
5XNG
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BU of 5xng by Molmil
EFK17A structure in Microgel MAA60
Descriptor: Cathelicidin antimicrobial peptide
Authors:Datta, A, Bhunia, A.
Deposit date:2017-05-22
Release date:2018-04-18
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Conformational Aspects of High Content Packing of Antimicrobial Peptides in Polymer Microgels
ACS Appl Mater Interfaces, 9, 2017
5XRX
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BU of 5xrx by Molmil
EFK17DA structure in Microgel MAA60
Descriptor: Cathelicidin antimicrobial peptide
Authors:Datta, A, Bhunia, A.
Deposit date:2017-06-10
Release date:2018-04-18
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Conformational Aspects of High Content Packing of Antimicrobial Peptides in Polymer Microgels
ACS Appl Mater Interfaces, 9, 2017
8C3U
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BU of 8c3u by Molmil
Crystal Structure of human IL-1beta in complex with a low molecular weight antagonist
Descriptor: (S)-4'-hydroxy-3'-(6-methyl-2-oxo-3-(1H-pyrazol-4-yl)indolin-3-yl)-[1,1'-biphenyl]-2,4-dicarboxylic acid, Interleukin-1 beta
Authors:Rondeau, J.-M, Lehmann, S, Koch, E.
Deposit date:2022-12-28
Release date:2023-09-13
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.945 Å)
Cite:Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1 beta.
Nat Commun, 14, 2023
1GC2
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BU of 1gc2 by Molmil
CRYSTAL STRUCTURE OF THE PYRIDOXAL-5'-PHOSPHATE DEPENDENT L-METHIONINE GAMMA-LYASE FROM PSEUDOMONAS PUTIDA
Descriptor: METHIONINE GAMMA-LYASE
Authors:Motoshima, H, Inagaki, K, Kumasaka, T, Furuichi, M, Inoue, H, Tamura, T, Esaki, N, Soda, K, Tanaka, N, Yamamoto, M, Tanaka, H.
Deposit date:2000-07-06
Release date:2002-05-08
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the pyridoxal 5'-phosphate dependent L-methionine gamma-lyase from Pseudomonas putida.
J.Biochem., 128, 2000
1GC0
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BU of 1gc0 by Molmil
CRYSTAL STRUCTURE OF THE PYRIDOXAL-5'-PHOSPHATE DEPENDENT L-METHIONINE GAMMA-LYASE FROM PSEUDOMONAS PUTIDA
Descriptor: METHIONINE GAMMA-LYASE
Authors:Motoshima, H, Inagaki, K, Kumasaka, T, Furuichi, M, Inoue, H, Tamura, T, Esaki, N, Soda, K, Tanaka, N, Yamamoto, M, Tanaka, H.
Deposit date:2000-07-06
Release date:2002-05-08
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the pyridoxal 5'-phosphate dependent L-methionine gamma-lyase from Pseudomonas putida.
J.Biochem., 128, 2000
3FE7
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BU of 3fe7 by Molmil
Crystal Structure of HdmX bound to the p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-Trp-Glu-Ac3c-Leu-NH2 at 1.35A
Descriptor: Mdm4 protein, p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-Trp-Glu-Ac3c-Leu-NH2
Authors:Kallen, J.
Deposit date:2008-11-28
Release date:2009-01-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes
J.Biol.Chem., 284, 2009
2NAT
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BU of 2nat by Molmil
Structural insights into interaction of KYE28 and lipopolysachharide
Descriptor: Heparin cofactor 2
Authors:Bhunia, A, Malmsten, M, Datta, A.
Deposit date:2016-01-11
Release date:2016-05-18
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Role of Aromatic Amino Acids in Lipopolysaccharide and Membrane Interactions of Antimicrobial Peptides for Use in Plant Disease Control.
J. Biol. Chem., 291, 2016
2NAU
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BU of 2nau by Molmil
Solution structure of KYE28A in lipopolysachharide
Descriptor: entity
Authors:Bhunia, A, Malmsten, M, Datta, A.
Deposit date:2016-01-11
Release date:2016-05-18
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Role of Aromatic Amino Acids in Lipopolysaccharide and Membrane Interactions of Antimicrobial Peptides for Use in Plant Disease Control.
J. Biol. Chem., 291, 2016
2PJL
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BU of 2pjl by Molmil
Crystal Structure of Human Estrogen-Related Receptor alpha in Complex with a Synthetic Inverse Agonist reveals its Novel Molecular Mechanism
Descriptor: 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE, Steroid hormone receptor ERR1
Authors:Kallen, J.
Deposit date:2007-04-16
Release date:2007-06-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism.
J.Biol.Chem., 282, 2007
2NCU
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BU of 2ncu by Molmil
NMR structure of KYE21 in LPS micelles
Descriptor: Heparin cofactor 2
Authors:Datta, A, Bhunia, A, Malmsten, M.
Deposit date:2016-04-18
Release date:2017-03-01
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Tryptophan end-tagging for promoted lipopolysaccharide interactions and anti-inflammatory effects.
Sci Rep, 7, 2017
2NCW
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BU of 2ncw by Molmil
NMR structure of WWWKYE21 structure in LPS micelles
Descriptor: Heparin cofactor 2
Authors:Datta, A, Bhunia, A.
Deposit date:2016-04-18
Release date:2017-03-01
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Tryptophan end-tagging for promoted lipopolysaccharide interactions and anti-inflammatory effects.
Sci Rep, 7, 2017
6CCN
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BU of 6ccn by Molmil
Crystal structure of E.coli Phosphopantetheine Adenylyltransferase (PPAT/CoaD) in complex with (R)-2,4-dihydroxy-N-(2-(4-hydroxy-1H-benzo[d]imidazol-2-yl)ethyl)-3,3-dimethylbutanamide
Descriptor: (2R)-2,4-dihydroxy-N-[2-(7-hydroxy-1H-benzimidazol-2-yl)ethyl]-3,3-dimethylbutanamide, Phosphopantetheine adenylyltransferase, SULFATE ION
Authors:Mamo, M, Appleton, B.A.
Deposit date:2018-02-07
Release date:2018-03-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.
J. Med. Chem., 61, 2018
6CCK
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BU of 6cck by Molmil
Crystal structure of E.coli Phosphopantetheine Adenylyltransferase (PPAT/CoaD) in complex with (R)-3-(3-chlorophenyl)-3-((5-methyl-7-oxo-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)amino)propanenitrile
Descriptor: (3R)-3-(3-chlorophenyl)-3-[(5-methyl-7-oxo-6,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)amino]propanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Mamo, M, Appleton, B.A.
Deposit date:2018-02-07
Release date:2018-03-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.
J. Med. Chem., 61, 2018

221716

數據於2024-06-26公開中

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