7KPA
asymmetric hTNF-alpha
Summary for 7KPA
Entry DOI | 10.2210/pdb7kpa/pdb |
Descriptor | Tumor necrosis factor, 5-(1-{[2-(difluoromethoxy)phenyl]methyl}-2-{[3-(2-oxopyrrolidin-1-yl)phenoxy]methyl}-1H-benzimidazol-6-yl)pyridin-2(1H)-one (3 entities in total) |
Functional Keywords | tnf, receptor, tnfr1, symmetric, cytokine |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 52929.77 |
Authors | Fox III, D.,Lukacs, C.M.,Ceska, T. (deposition date: 2020-11-10, release date: 2021-01-13, Last modification date: 2024-04-03) |
Primary citation | Lightwood, D.J.,Munro, R.J.,Porter, J.,McMillan, D.,Carrington, B.,Turner, A.,Scott-Tucker, A.,Hickford, E.S.,Schmidt, A.,Fox III, D.,Maloney, A.,Ceska, T.,Bourne, T.,O'Connell, J.,Lawson, A.D.G. A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF. Nat Commun, 12:583-583, 2021 Cited by PubMed: 33495445DOI: 10.1038/s41467-020-20825-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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