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4RG2
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BU of 4rg2 by Molmil
Tudor Domain of Tumor suppressor p53BP1 with small molecule ligand
Descriptor: 1,2-ETHANEDIOL, 3-bromo-N-[3-(tert-butylamino)propyl]benzamide, Tumor suppressor p53-binding protein 1, ...
Authors:Dong, A, Mader, P, James, L, Perfetti, M, Tempel, W, Frye, S, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2014-09-29
Release date:2014-10-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.
ACS Chem. Biol., 10, 2015
4D4F
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BU of 4d4f by Molmil
Mutant P250A of bacterial chalcone isomerase from Eubacterium ramulus
Descriptor: CHALCONE ISOMERASE, CHLORIDE ION, GLYCEROL
Authors:Thomsen, M, Kratzat, H, Hinrichs, W.
Deposit date:2014-10-28
Release date:2016-01-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structural Basis for (2 R ,3 R )-Taxifolin Binding and Reaction Products to the Bacterial Chalcone Isomerase of Eubacterium ramulus.
Molecules, 27, 2022
3NDB
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BU of 3ndb by Molmil
Crystal structure of a signal sequence bound to the signal recognition particle
Descriptor: PHOSPHATE ION, SRP RNA, Signal recognition 54 kDa protein, ...
Authors:Hainzl, T, Huang, S, Sauer-Eriksson, E.
Deposit date:2010-06-07
Release date:2011-02-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of signal-sequence recognition by the signal recognition particle.
Nat.Struct.Mol.Biol., 18, 2011
8S9L
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BU of 8s9l by Molmil
Structure of monomeric FAM111A SPD V347D Mutant
Descriptor: SULFATE ION, Serine protease FAM111A
Authors:Palani, S, Alvey, J.A, Cong, A.T.Q, Schellenberg, M.J, Machida, Y.
Deposit date:2023-03-29
Release date:2024-03-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisomerase 1 cleavage complexes.
Nat Commun, 15, 2024
8S9K
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BU of 8s9k by Molmil
Structure of dimeric FAM111A SPD S541A Mutant
Descriptor: GLYCEROL, Serine protease FAM111A
Authors:Palani, S, Alvey, J.A, Cong, A.T.Q, Schellenberg, M.J, Machida, Y.
Deposit date:2023-03-29
Release date:2024-03-20
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisomerase 1 cleavage complexes.
Nat Commun, 15, 2024
3LX7
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BU of 3lx7 by Molmil
Crystal structure of a Novel Tudor domain-containing protein SGF29
Descriptor: SAGA-associated factor 29 homolog, SULFATE ION, UNKNOWN ATOM OR ION
Authors:Bian, C.B, Xu, C, Tempel, W, Lam, R, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bochkarev, A, Min, J.
Deposit date:2010-02-24
Release date:2010-05-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.
Embo J., 30, 2011
5TAB
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BU of 5tab by Molmil
Crystal Structure of the PHD Finger of PHF20
Descriptor: GLYCEROL, PHD finger protein 20, ZINC ION
Authors:Klein, B.J, Kutateladze, T.G.
Deposit date:2016-09-09
Release date:2016-10-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.
Cell Rep, 17, 2016
3MEV
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BU of 3mev by Molmil
Crystal structure of SGF29 in complex with R2AK4me3
Descriptor: GLYCEROL, Histone H3, SAGA-associated factor 29 homolog, ...
Authors:Bian, C.B, Xu, C, Lam, R, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2010-03-31
Release date:2010-04-28
Last modified:2021-10-06
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.
Embo J., 30, 2011
3MEU
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BU of 3meu by Molmil
Crystal structure of SGF29 in complex with H3R2me2sK4me3
Descriptor: Histone H3, SAGA-associated factor 29 homolog, SULFATE ION
Authors:Bian, C.B, Xu, C, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2010-03-31
Release date:2010-04-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.
Embo J., 30, 2011
3MP1
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BU of 3mp1 by Molmil
Complex structure of Sgf29 and trimethylated H3K4
Descriptor: ACETATE ION, H3K4me3 peptide, Maltose-binding periplasmic protein,LINKER,SAGA-associated factor 29, ...
Authors:Li, J, Ruan, J, Wu, M, Xue, X, Zang, J.
Deposit date:2010-04-24
Release date:2011-05-04
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation
Embo J., 30, 2011
3MEW
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BU of 3mew by Molmil
Crystal structure of Novel Tudor domain-containing protein SGF29
Descriptor: SAGA-associated factor 29 homolog
Authors:Xu, C, Bian, C.B, Lam, R, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2010-03-31
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.
Embo J., 30, 2011
3MEA
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BU of 3mea by Molmil
Crystal structure of the SGF29 in complex with H3K4me3
Descriptor: Histone H3, SAGA-associated factor 29 homolog
Authors:Bian, C, Xu, C, Tempel, W, MacKenzie, F, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2010-03-31
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.
Embo J., 30, 2011
3MP6
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BU of 3mp6 by Molmil
Complex Structure of Sgf29 and dimethylated H3K4
Descriptor: H3K4me2 peptide, Maltose-binding periplasmic protein,LINKER,SAGA-associated factor 29, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Li, J, Wu, M, Ruan, J, Zang, J.
Deposit date:2010-04-25
Release date:2011-05-04
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation
Embo J., 30, 2011
3MET
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BU of 3met by Molmil
Crystal structure of SGF29 in complex with H3K4me2
Descriptor: GLYCEROL, Histone H3, SAGA-associated factor 29 homolog, ...
Authors:Bian, C.B, Xu, C, Lam, R, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2010-03-31
Release date:2010-04-28
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.
Embo J., 30, 2011
3MP8
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BU of 3mp8 by Molmil
Crystal structure of Sgf29 tudor domain
Descriptor: 4-(HYDROXYMETHYL)BENZAMIDINE, ACETIC ACID, GLYCEROL, ...
Authors:Li, J, Wu, M, Ruan, J, Zang, J.
Deposit date:2010-04-26
Release date:2011-05-04
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation
Embo J., 30, 2011
3ME9
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BU of 3me9 by Molmil
Crystal structure of SGF29 in complex with H3K4me3 peptide
Descriptor: GLYCEROL, Histone H3, SAGA-associated factor 29 homolog, ...
Authors:Bian, C, Tempel, W, Xu, C, Guo, Y, Dong, A, Crombet, L, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2010-03-31
Release date:2010-04-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.
Embo J., 30, 2011
5LGN
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BU of 5lgn by Molmil
Thieno[3,2-b]pyrrole-5-carboxamides as Novel Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1: Compound 19
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1A, REST corepressor 1, ...
Authors:Mattevi, A, Ciossani, G.
Deposit date:2016-07-07
Release date:2017-02-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.
J. Med. Chem., 60, 2017
7P7G
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BU of 7p7g by Molmil
Crystal structure of phosphorylated pT220 Casein Kinase I delta (CK1d), conformation 2 and 3
Descriptor: 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, CITRIC ACID, ...
Authors:Chaikuad, A, Zhubi, R, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-07-19
Release date:2022-04-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes.
Mol.Cell, 82, 2022
7P7H
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BU of 7p7h by Molmil
Crystal structure of Casein Kinase I delta (CK1d) with alphaG-in conformation
Descriptor: ADENOSINE MONOPHOSPHATE, Casein kinase I isoform delta
Authors:Chaikuad, A, Zhubi, R, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-07-19
Release date:2022-04-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes.
Mol.Cell, 82, 2022
7P7F
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BU of 7p7f by Molmil
Crystal structure of phosphorylated pT220 Casein Kinase I delta (CK1d), conformation 1
Descriptor: 1,2-ETHANEDIOL, ADENOSINE, ADENOSINE MONOPHOSPHATE, ...
Authors:Chaikuad, A, Zhubi, R, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-07-19
Release date:2022-04-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes.
Mol.Cell, 82, 2022
4RHV
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BU of 4rhv by Molmil
THE USE OF MOLECULAR-REPLACEMENT PHASES FOR THE REFINEMENT OF THE HUMAN RHINOVIRUS 14 STRUCTURE
Descriptor: HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP3), ...
Authors:Arnold, E, Rossmann, M.G.
Deposit date:1988-01-25
Release date:1988-04-16
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:The use of molecular-replacement phases for the refinement of the human rhinovirus 14 structure.
Acta Crystallogr.,Sect.A, 44, 1988
7OT9
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BU of 7ot9 by Molmil
Structure of the AI-2 exporter family protein YdiK from E. coli
Descriptor: AI-2E member YdiK
Authors:Khera, R, Xie, H, Michel, H.
Deposit date:2021-06-09
Release date:2022-05-11
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-EM structures of pentameric autoinducer-2 exporter from Escherichia coli reveal its transport mechanism.
Embo J., 41, 2022
5O6O
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BU of 5o6o by Molmil
17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal 2,6-pyridinketone inhibitor
Descriptor: 17-beta-hydroxysteroid dehydrogenase 14, 2-fluoranyl-3-[6-(4-fluoranyl-3-oxidanyl-phenoxy)pyridin-2-yl]phenol, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Bertoletti, N, Heine, A, Braun, F, Klebe, G, Marchais-Oberwinkler, S.
Deposit date:2017-06-07
Release date:2018-06-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure-based design and profiling of novel 17 beta-HSD14 inhibitors.
Eur J Med Chem, 155, 2018
5O6Z
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BU of 5o6z by Molmil
17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal quinoline based inhibitor
Descriptor: (4-fluoranyl-3-oxidanyl-phenyl)-quinolin-2-yl-methanone, 17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Bertoletti, N, Braun, F, Heine, A, Klebe, G, Marchais-Oberwinkler, S.
Deposit date:2017-06-07
Release date:2018-06-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Structure-based design and profiling of novel 17 beta-HSD14 inhibitors.
Eur J Med Chem, 155, 2018
5O6X
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BU of 5o6x by Molmil
17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal quinoline based inhibitor
Descriptor: (4-fluoranyl-3-oxidanyl-phenyl)-(6-methylquinolin-2-yl)methanone, 17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Bertoletti, N, Braun, F, Heine, A, Klebe, G, Marchais-Oberwinkler, S.
Deposit date:2017-06-07
Release date:2018-06-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure-based design and profiling of novel 17 beta-HSD14 inhibitors.
Eur J Med Chem, 155, 2018

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數據於2024-09-11公開中

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