4O9S
| Crystal structure of Retinol-Binding Protein 4 (RBP4)in complex with a non-retinoid ligand | Descriptor: | 1,2-ETHANEDIOL, 1-[4-(7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(12),2(6),8,10-tetraen-12-yl)piperazin-1-yl]-2-[2-(trifluoromethyl)phenyl]ethanone, CHLORIDE ION, ... | Authors: | Wang, Z, Johnstone, S, Walker, N.P. | Deposit date: | 2014-01-02 | Release date: | 2014-07-02 | Last modified: | 2020-02-19 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4. Bioorg.Med.Chem.Lett., 24, 2014
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4Q2Q
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5ZZ3
| Crystal structure of intracellular B30.2 domain of BTN3A3 | Descriptor: | Butyrophilin, subfamily 3, member A3 isoform b variant | Authors: | Yang, Y.Y, Li, X, Liu, W.D, Chen, C.C, Guo, R.T, Zhang, Y.H. | Deposit date: | 2018-05-30 | Release date: | 2019-04-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation. Immunity, 50, 2019
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4Q2O
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4Q2P
| NHERF3 PDZ2 in Complex with a Phage-Derived Peptide | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Na(+)/H(+) exchange regulatory cofactor NHE-RF3 | Authors: | Appleton, B.A, Wiesmann, C. | Deposit date: | 2014-04-09 | Release date: | 2014-09-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | A structural portrait of the PDZ domain family. J.Mol.Biol., 426, 2014
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4Q2N
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5BTZ
| Structure of the middle domain of lpg1496 from Legionella pneumophila in P212121 space group | Descriptor: | lpg1496 | Authors: | Wong, K, Kozlov, G, Gehring, K, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | Deposit date: | 2015-06-03 | Release date: | 2015-08-26 | Last modified: | 2020-01-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of the Legionella Effector, lpg1496, Suggests a Role in Nucleotide Metabolism. J.Biol.Chem., 290, 2015
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5XK6
| Structure of a prenyltransferase soaked with IPP | Descriptor: | MAGNESIUM ION, PYROPHOSPHATE 2-, SULFATE ION, ... | Authors: | Ko, T.P, Guo, R.T, Liu, W, Chen, C.C, Gao, J. | Deposit date: | 2017-05-05 | Release date: | 2018-01-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase. Angew. Chem. Int. Ed. Engl., 57, 2018
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5BTX
| Structure of the N-terminal domain of lpg1496 from Legionella pneumophila in complex with nucleotide | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, lpg1496 | Authors: | Wong, K, Kozlov, G, Gehring, K, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | Deposit date: | 2015-06-03 | Release date: | 2015-08-26 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of the Legionella Effector, lpg1496, Suggests a Role in Nucleotide Metabolism. J.Biol.Chem., 290, 2015
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7M17
| SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-1) | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid, Volume-regulated anion channel subunit LRRC8A | Authors: | Kern, D.M, Gerber, E.E, Brohawn, S.G. | Deposit date: | 2021-03-12 | Release date: | 2021-03-24 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes. Nat Commun, 13, 2022
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7M19
| SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-2) | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid, Volume-regulated anion channel subunit LRRC8A | Authors: | Kern, D.M, Gerber, E.E, Brohawn, S.G. | Deposit date: | 2021-03-12 | Release date: | 2021-03-24 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.69 Å) | Cite: | Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes. Nat Commun, 13, 2022
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7Y04
| Hsp90-AhR-p23 complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Aryl hydrocarbon receptor, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Wen, Z.L, Zhai, Y.J, Zhu, Y, Sun, F. | Deposit date: | 2022-06-03 | Release date: | 2023-01-04 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structure of the cytosolic AhR complex. Structure, 31, 2023
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5XK3
| Crystal structure of apo form Isosesquilavandulyl Diphosphate Synthase from Streptomyces sp. strain CNH-189 | Descriptor: | SULFATE ION, Undecaprenyl diphosphate synthase | Authors: | Ko, T.P, Guo, R.T, Liu, W, Chen, C.C, Gao, J. | Deposit date: | 2017-05-05 | Release date: | 2018-01-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.996 Å) | Cite: | "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase. Angew. Chem. Int. Ed. Engl., 57, 2018
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3GVG
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3GWC
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5BU2
| Structure of the C-terminal domain of lpg1496 from Legionella pneumophila in complex with nucleotide | Descriptor: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, alpha-D-ribofuranose, ... | Authors: | Wong, K, Kozlov, G, Gehring, K, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | Deposit date: | 2015-06-03 | Release date: | 2015-08-26 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Structure of the Legionella Effector, lpg1496, Suggests a Role in Nucleotide Metabolism. J.Biol.Chem., 290, 2015
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3H81
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5BU1
| Structure of the truncated C-terminal domain of lpg1496 from Legionella pneumophila | Descriptor: | LPG1496, MALONATE ION | Authors: | Wong, K, Kozlov, G, Gehring, K, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | Deposit date: | 2015-06-03 | Release date: | 2015-08-26 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of the Legionella Effector, lpg1496, Suggests a Role in Nucleotide Metabolism. J.Biol.Chem., 290, 2015
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5XK8
| Crystal structure of Isosesquilavandulyl Diphosphate Synthase from Streptomyces sp. strain CNH-189 in complex with GPP | Descriptor: | GERANYL DIPHOSPHATE, MAGNESIUM ION, Undecaprenyl diphosphate synthase | Authors: | Ko, T.P, Guo, R.T, Liu, W, Chen, C.C, Gao, J. | Deposit date: | 2017-05-05 | Release date: | 2018-01-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.304 Å) | Cite: | "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase. Angew. Chem. Int. Ed. Engl., 57, 2018
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8WGV
| BA.2(S375) Spike (S6P)/hACE2 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Wei, X, Zhang, Z. | Deposit date: | 2023-09-22 | Release date: | 2024-02-28 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis. Nat.Immunol., 25, 2024
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8WGW
| Local refinement of RBD-ACE2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Wei, X, Zhang, Z. | Deposit date: | 2023-09-22 | Release date: | 2024-02-28 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis. Nat.Immunol., 25, 2024
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3HWK
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1B9E
| HUMAN INSULIN MUTANT SERB9GLU | Descriptor: | PROTEIN (INSULIN) | Authors: | Wang, D.C, Zeng, Z.H, Yao, Z.P, Li, H.M. | Deposit date: | 1998-11-12 | Release date: | 1999-11-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of an insulin dimer in an orthorhombic crystal: the structure analysis of a human insulin mutant (B9 Ser-->Glu). Acta Crystallogr.,Sect.D, 55, 1999
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3ICO
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5CF5
| CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-7-[(DIMETHYL-1,3-THIAZOL-2-YL)AMINO]-10-ETHYL-3-METHYL-3,5,8,10-TETRAAZATRICYCLO[7.3.0.02,6] DODECA-1(9),2(6),4,7,11-PENTAENE-11-CARBOXAMIDE | Descriptor: | N,N-dicyclopropyl-4-[(4,5-dimethyl-1,3-thiazol-2-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide, Tyrosine-protein kinase JAK2 | Authors: | Sack, J.S. | Deposit date: | 2015-07-08 | Release date: | 2015-08-26 | Last modified: | 2015-09-02 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors. Acs Med.Chem.Lett., 6, 2015
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