8EHW
 
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8EHX
 | | cryo-EM structure of TMEM63B in LMNG | | Descriptor: | CSC1-like protein 2 | | Authors: | Zheng, W, Fu, T.M, Holt, J.R. | | Deposit date: | 2022-09-14 | | Release date: | 2023-08-23 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels.
Neuron, 111, 2023
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8TJY
 | | Structure of Gabija AB complex | | Descriptor: | Endonuclease GajA, Gabija protein GajB | | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | | Deposit date: | 2023-07-24 | | Release date: | 2024-04-24 | | Last modified: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.79 Å) | | Cite: | Molecular basis of Gabija anti-phage supramolecular assemblies.
Nat.Struct.Mol.Biol., 31, 2024
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8TK1
 | | Structure of Gabija AB complex 1 | | Descriptor: | Endonuclease GajA, Gabija protein GajB | | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | | Deposit date: | 2023-07-25 | | Release date: | 2024-04-24 | | Last modified: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Molecular basis of Gabija anti-phage supramolecular assemblies.
Nat.Struct.Mol.Biol., 31, 2024
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8TK0
 | | Structure of Gabija AB complex | | Descriptor: | Endonuclease GajA | | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | | Deposit date: | 2023-07-24 | | Release date: | 2024-04-24 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Molecular basis of Gabija anti-phage supramolecular assemblies.
Nat.Struct.Mol.Biol., 31, 2024
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7L5B
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9BGK
 | | Structure of V.cholera DdmDE (2D:1E) in complex with DNA | | Descriptor: | DdmE, Helicase/UvrB N-terminal domain-containing protein, MAGNESIUM ION, ... | | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | | Deposit date: | 2024-04-19 | | Release date: | 2024-10-23 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | DdmDE eliminates plasmid invasion by DNA-guided DNA targeting.
Cell, 187, 2024
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6CDO
 | | Structure of vaccine-elicited HIV-1 neutralizing antibody vFP16.02 in complex with HIV-1 fusion peptide residue 512-519 | | Descriptor: | HIV-1 fusion peptide 512-519, SULFATE ION, vFP16.02 Fab heavy chain, ... | | Authors: | Xu, K, Liu, K, Kwong, P.D. | | Deposit date: | 2018-02-08 | | Release date: | 2018-05-16 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (2.099 Å) | | Cite: | Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
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7EZP
 | | Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase | | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 3-(3-hydroxy-3-oxopropyl)-5-(2-methylpropyl)-7-nitro-1H-indole-2-carboxylic acid, Fructose-1,6-bisphosphatase 1 | | Authors: | Wang, X.Y, Zhou, J, Xu, B.L. | | Deposit date: | 2021-06-01 | | Release date: | 2022-06-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis.
Acs Med.Chem.Lett., 13, 2022
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7EZR
 | | Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase | | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 5-ethyl-7-nitro-3-[3-oxidanylidene-3-(thiophen-2-ylsulfonylamino)propyl]-1H-indole-2-carboxylic acid, Fructose-1,6-bisphosphatase 1 | | Authors: | Wang, X.Y, Zhou, J, Xu, B.L. | | Deposit date: | 2021-06-01 | | Release date: | 2022-06-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.27 Å) | | Cite: | Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis.
Acs Med.Chem.Lett., 13, 2022
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7EZF
 | | Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase | | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 7-chloranyl-5-ethyl-3-(3-hydroxy-3-oxopropyl)-1H-indole-2-carboxylic acid, Fructose-1,6-bisphosphatase 1 | | Authors: | Wang, X.Y, Zhou, J, Xu, B.L. | | Deposit date: | 2021-06-01 | | Release date: | 2022-06-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.76 Å) | | Cite: | Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis.
Acs Med.Chem.Lett., 13, 2022
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6CDP
 | | Vaccine-elicited HIV-1 neutralizing antibody vFP20.01 in complex with HIV-1 fusion peptide residue 512-519 | | Descriptor: | HIV-1 fusion peptide 512-519, SULFATE ION, vFP20.01 Fab heavy chain, ... | | Authors: | Xu, K, Liu, K, Kwong, P.D. | | Deposit date: | 2018-02-08 | | Release date: | 2018-05-16 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.456 Å) | | Cite: | Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
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6L9J
 | | Structure of yeast Snf5 and Swi3 subcomplex | | Descriptor: | GLYCEROL, SWI/SNF chromatin-remodeling complex subunit SNF5, SWI/SNF complex subunit SWI3 | | Authors: | Long, J, Zhou, H. | | Deposit date: | 2019-11-10 | | Release date: | 2020-11-11 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.642 Å) | | Cite: | Snf5 and Swi3 subcomplex formation is required for SWI/SNF complex function in yeast.
Biochem.Biophys.Res.Commun., 526, 2020
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9C6Q
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6LNL
 | | ASFV core shell protein p15 | | Descriptor: | 60 kDa polyprotein | | Authors: | Guo, F, Shi, Y, Peng, G. | | Deposit date: | 2019-12-30 | | Release date: | 2020-12-30 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.9286 Å) | | Cite: | The structural basis of African swine fever virus core shell protein p15 binding to DNA.
Faseb J., 35, 2021
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6CDE
 | | Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, ... | | Authors: | Acharya, P, Xu, K, Liu, K, Carragher, B, Potter, C.S, Kwong, P.D. | | Deposit date: | 2018-02-08 | | Release date: | 2018-05-16 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
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6CDI
 | | Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, ... | | Authors: | Acharya, P, Xu, K, Liu, K, Carragher, B, Potter, C.S, Kwong, P.D. | | Deposit date: | 2018-02-08 | | Release date: | 2018-05-16 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
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6CDM
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6E5P
 | | Backbone model based on cryo-EM map at 8.5 A of domain-swapped, glycan-reactive, neutralizing antibody 2G12 bound to HIV-1 Env BG505 DS-SOSIP, which was also bound to CD4-binding site antibody VRC03 | | Descriptor: | 2G12 Light chain, 2G12 heavy chain, Envelope glycoprotein gp120, ... | | Authors: | Acharya, P, Kwong, P.D. | | Deposit date: | 2018-07-21 | | Release date: | 2019-02-13 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (8.8 Å) | | Cite: | Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition.
Structure, 27, 2019
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7JUO
 | | CBP bromodomain complexed with YF2-23 | | Descriptor: | CREB-binding protein, N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-(1-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-3-yl)-1H-indol-4-yl}ethanesulfonamide | | Authors: | Ratia, K.M, Xiong, R, Principe, D, Li, Y, Huang, F, Rana, A, Thatcher, G. | | Deposit date: | 2020-08-20 | | Release date: | 2021-09-01 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8GH8
 | | RuvA Holliday junction DNA complex | | Descriptor: | DNA (34-MER), Holliday junction branch migration complex subunit RuvA | | Authors: | Rish, A.D, Fu, T. | | Deposit date: | 2023-03-09 | | Release date: | 2023-05-10 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Molecular mechanisms of Holliday junction branch migration catalyzed by an asymmetric RuvB hexamer.
Nat Commun, 14, 2023
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7CQP
 | | Complex of TRPC4 and Calmodulin_Nlobe | | Descriptor: | CALCIUM ION, Calmodulin-1, Peptide from Short transient receptor potential channel 4 | | Authors: | Shen, Z.S. | | Deposit date: | 2020-08-11 | | Release date: | 2021-06-23 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Calmodulin binds to Drosophila TRP with an unexpected mode.
Structure, 29, 2021
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7CQH
 | | Complex of TRP_CBS2 and Calmodulin_Clobe | | Descriptor: | AT15141p, CALCIUM ION, Transient receptor potential protein | | Authors: | Shen, Z.S. | | Deposit date: | 2020-08-10 | | Release date: | 2021-06-23 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Calmodulin binds to Drosophila TRP with an unexpected mode.
Structure, 29, 2021
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7CQV
 | | Complex of TRP_CBS1 and Calmodulin_Nlobe | | Descriptor: | AT15141p, CALCIUM ION, Transient receptor potential protein | | Authors: | Shen, Z.S. | | Deposit date: | 2020-08-11 | | Release date: | 2021-06-23 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Calmodulin binds to Drosophila TRP with an unexpected mode.
Structure, 29, 2021
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8EM7
 | | Cryo-EM structure of LRP2 at pH 5.2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Beenken, A, Cerutti, G, Fitzpatrick, A.W, Barasch, J, Shapiro, L. | | Deposit date: | 2022-09-27 | | Release date: | 2023-02-08 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Structures of LRP2 reveal a molecular machine for endocytosis.
Cell, 186, 2023
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