6SZV
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![BU of 6szv by Molmil](/molmil-images/mine/6szv) | Bat Influenza A polymerase elongation complex with incoming UTP analogue (core + endonuclease only) | Descriptor: | 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ... | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | Deposit date: | 2019-10-02 | Release date: | 2020-04-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
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6T0U
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![BU of 6t0u by Molmil](/molmil-images/mine/6t0u) | Bat Influenza A polymerase product dissociation complex using 44-mer vRNA template with intact oligo(U) sequence | Descriptor: | Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit, ... | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | Deposit date: | 2019-10-03 | Release date: | 2020-04-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
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8AZA
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![BU of 8aza by Molmil](/molmil-images/mine/8aza) | Structure of RIP2K dimer bound to the XIAP BIR2 domain | Descriptor: | E3 ubiquitin-protein ligase XIAP, Receptor-interacting serine/threonine-protein kinase 2, ZINC ION | Authors: | Pellegrini, E, Cusack, S. | Deposit date: | 2022-09-05 | Release date: | 2022-10-26 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface. Life Sci Alliance, 6, 2023
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6SZU
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![BU of 6szu by Molmil](/molmil-images/mine/6szu) | Bat Influenza A polymerase pre-termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence | Descriptor: | 5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | Deposit date: | 2019-10-02 | Release date: | 2020-04-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.41 Å) | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
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6T0V
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![BU of 6t0v by Molmil](/molmil-images/mine/6t0v) | Bat Influenza A polymerase elongation complex with incoming UTP analogue (complete polymerase) | Descriptor: | 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ... | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | Deposit date: | 2019-10-03 | Release date: | 2020-04-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
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6T0W
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![BU of 6t0w by Molmil](/molmil-images/mine/6t0w) | Human Influenza B polymerase recycling complex | Descriptor: | Polymerase PB2, Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, ... | Authors: | Wandzik, J.M, Kouba, T, Karuppasamy, M, Cusack, S. | Deposit date: | 2019-10-03 | Release date: | 2020-04-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
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7PQK
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![BU of 7pqk by Molmil](/molmil-images/mine/7pqk) | |
8ASG
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![BU of 8asg by Molmil](/molmil-images/mine/8asg) | Structure of the SFTSV L protein bound in a resting state [RESTING] | Descriptor: | MAGNESIUM ION, RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*AP*UP*GP*A*)-3'), RNA (5'-R(*GP*AP*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U*)-3'), ... | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | Deposit date: | 2022-08-19 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 51, 2023
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8ASB
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![BU of 8asb by Molmil](/molmil-images/mine/8asb) | Structure of the SFTSV L protein stalled at early elongation with the endonuclease domain in a raised conformation [EARLY-ELONGATION-ENDO] | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*A)-3'), ... | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | Deposit date: | 2022-08-18 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 51, 2023
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8ASD
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![BU of 8asd by Molmil](/molmil-images/mine/8asd) | Structure of the SFTSV L protein stalled at late elongation [LATE-ELONGATION] | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*GP*AP*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3'), ... | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | Deposit date: | 2022-08-19 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 51, 2023
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8AS6
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![BU of 8as6 by Molmil](/molmil-images/mine/8as6) | Structure of the SFTSV L protein bound to 5' cRNA hook [5' HOOK] | Descriptor: | RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*C)-3'), RNA-dependent RNA-polymerase L protein | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | Deposit date: | 2022-08-18 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 51, 2023
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8AS7
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![BU of 8as7 by Molmil](/molmil-images/mine/8as7) | Structure of the SFTSV L protein stalled at early elongation [EARLY-ELONGATION] | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, ... | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | Deposit date: | 2022-08-18 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 51, 2023
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6T2C
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![BU of 6t2c by Molmil](/molmil-images/mine/6t2c) | Bat Influenza A polymerase recycling complex | Descriptor: | MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ... | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | Deposit date: | 2019-10-08 | Release date: | 2020-04-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
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6TW1
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![BU of 6tw1 by Molmil](/molmil-images/mine/6tw1) | Bat Influenza A polymerase termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence | Descriptor: | 5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | Authors: | Wandzik, J.M, Kouba, T, Cusack, S. | Deposit date: | 2020-01-11 | Release date: | 2020-04-15 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 2020
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1QHV
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![BU of 1qhv by Molmil](/molmil-images/mine/1qhv) | HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD | Descriptor: | PROTEIN (ADENOVIRUS FIBRE), SULFATE ION | Authors: | Van Raaij, M.J, Louis, N, Chroboczek, J, Cusack, S. | Deposit date: | 1999-05-28 | Release date: | 1999-09-29 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution. Virology, 262, 1999
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1QIU
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![BU of 1qiu by Molmil](/molmil-images/mine/1qiu) | |
8BY6
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![BU of 8by6 by Molmil](/molmil-images/mine/8by6) | Structure of the human nuclear cap-binding complex bound to NCBP3(560-620) and cap-analogue m7GpppG | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ... | Authors: | Dubiez, E, Pellegrini, E, Foucher, A.E, Cusack, S, Kadlec, J. | Deposit date: | 2022-12-12 | Release date: | 2024-01-24 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex. Cell Rep, 43, 2024
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5NG2
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![BU of 5ng2 by Molmil](/molmil-images/mine/5ng2) | Structure of RIP2K(D146N) with bound Staurosporine | Descriptor: | PHOSPHATE ION, Receptor-interacting serine/threonine-protein kinase 2, STAUROSPORINE | Authors: | Pellegrini, E, Cusack, S. | Deposit date: | 2017-03-16 | Release date: | 2017-06-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation. PLoS ONE, 12, 2017
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8CI5
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![BU of 8ci5 by Molmil](/molmil-images/mine/8ci5) | Structure of the SNV L protein bound to 5' RNA | Descriptor: | RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*GP*AP*CP*U)-3'), RNA-directed RNA polymerase L | Authors: | Meier, K, Thorkelsson, S.R, Durieux Trouilleton, Q, Vogel, D, Yu, D, Kosinski, J, Cusack, S, Malet, H, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | Deposit date: | 2023-02-08 | Release date: | 2023-07-19 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural and functional characterization of the Sin Nombre virus L protein. Plos Pathog., 19, 2023
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5NG0
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![BU of 5ng0 by Molmil](/molmil-images/mine/5ng0) | Structure of RIP2K(L294F) with bound AMPPCP | Descriptor: | COBALT (II) ION, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Pellegrini, E, Cusack, S. | Deposit date: | 2017-03-16 | Release date: | 2017-06-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation. PLoS ONE, 12, 2017
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5NG3
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![BU of 5ng3 by Molmil](/molmil-images/mine/5ng3) | Structure of inactive kinase RIP2K(K47R) | Descriptor: | Receptor-interacting serine/threonine-protein kinase 2, SULFATE ION | Authors: | Pellegrini, E, Cusack, S. | Deposit date: | 2017-03-16 | Release date: | 2017-06-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation. PLoS ONE, 12, 2017
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1D4R
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![BU of 1d4r by Molmil](/molmil-images/mine/1d4r) | 29-mer fragment of human srp rna helix 6 | Descriptor: | 29-MER OF MODIFIED SRP RNA HELIX 6, MAGNESIUM ION | Authors: | Wild, K, Weichenrieder, O, Leonard, G.A, Cusack, S. | Deposit date: | 1999-10-05 | Release date: | 1999-12-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The 2 A structure of helix 6 of the human signal recognition particle RNA Structure Fold.Des., 7, 1999
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1E8O
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![BU of 1e8o by Molmil](/molmil-images/mine/1e8o) | Core of the Alu domain of the mammalian SRP | Descriptor: | 7SL RNA, SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN, SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN, ... | Authors: | Weichenrieder, O, Wild, K, Strub, K, Cusack, S. | Deposit date: | 2000-09-28 | Release date: | 2000-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure and Assembly of the Alu Domain of the Mammalian Signal Recognition Particle Nature, 408, 2000
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1E8S
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![BU of 1e8s by Molmil](/molmil-images/mine/1e8s) | Alu domain of the mammalian SRP (potential Alu retroposition intermediate) | Descriptor: | 7SL RNA, 88-MER, EUROPIUM (III) ION, ... | Authors: | Weichenrieder, O, Wild, K, Strub, K, Cusack, S. | Deposit date: | 2000-09-29 | Release date: | 2000-11-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Structure and Assembly of the Alu Domain of the Mammalian Signal Recognition Particle Nature, 408, 2000
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1ZZI
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![BU of 1zzi by Molmil](/molmil-images/mine/1zzi) | Crystal Structure Analysis of the third KH domain of hnRNP K in complex with ssDNA | Descriptor: | 5'-D(*CP*TP*CP*CP*CP*C)-3', Heterogeneous nuclear ribonucleoprotein K | Authors: | Backe, P.H, Messias, A.C, Ravelli, R.B, Sattler, M, Cusack, S. | Deposit date: | 2005-06-14 | Release date: | 2005-08-09 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | X-Ray Crystallographic and NMR Studies of the Third KH Domain of hnRNP K in Complex with Single-Stranded Nucleic Acids STRUCTURE, 13, 2005
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