4M68
 
 | | Crystal structure of the mouse MLKL kinase-like domain | | Descriptor: | GLYCEROL, Mixed lineage kinase domain-like protein | | Authors: | Xie, T, Peng, W, Yan, C, Wu, J, Shi, Y. | | Deposit date: | 2013-08-09 | | Release date: | 2013-10-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.696 Å) | | Cite: | Structural Insights into RIP3-Mediated Necroptotic Signaling
Cell Rep, 5, 2013
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4M7D
 | | Crystal structure of Lsm2-8 complex bound to the RNA fragment CGUUU | | Descriptor: | U6 snRNA, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ... | | Authors: | Zhou, L, Hang, J, Zhou, Y, Wan, R, Lu, G, Yan, C, Shi, Y. | | Deposit date: | 2013-08-12 | | Release date: | 2013-11-13 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.595 Å) | | Cite: | Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
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4M78
 | | Crystal structure of Lsm2-8 complex, space group P21 | | Descriptor: | U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, U6 snRNA-associated Sm-like protein LSm4, ... | | Authors: | Zhou, L, Hang, J, Zhou, Y, Wan, R, Lu, G, Yan, C, Shi, Y. | | Deposit date: | 2013-08-12 | | Release date: | 2013-11-13 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.794 Å) | | Cite: | Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
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4M66
 | | Crystal structure of the mouse RIP3 kinase domain | | Descriptor: | Receptor-interacting serine/threonine-protein kinase 3 | | Authors: | Xie, T, Peng, W, Yan, C, Wu, J, Shi, Y. | | Deposit date: | 2013-08-09 | | Release date: | 2013-10-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.401 Å) | | Cite: | Structural Insights into RIP3-Mediated Necroptotic Signaling
Cell Rep, 5, 2013
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5XJC
 | | Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Zhang, X, Yan, C, Hang, J, Finci, I.L, Lei, J, Shi, Y. | | Deposit date: | 2017-04-30 | | Release date: | 2017-07-05 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | An Atomic Structure of the Human Spliceosome
Cell, 169, 2017
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5YLZ
 | | Cryo-EM Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae at 3.6 angstrom | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Wan, R, Yan, C, Bai, R, Lei, J, Shi, Y. | | Deposit date: | 2017-10-20 | | Release date: | 2018-07-18 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae
Cell, 171, 2017
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5Y88
 | | Cryo-EM structure of the intron-lariat spliceosome ready for disassembly from S.cerevisiae at 3.5 angstrom | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Intron lariat, ... | | Authors: | Wan, R, Yan, C, Bai, R, Lei, J, Shi, Y. | | Deposit date: | 2017-08-20 | | Release date: | 2018-08-01 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae
Cell(Cambridge,Mass.), 171, 2017
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7WSM
 | | Cryo-EM structure of human glucose transporter GLUT4 bound to cytochalasin B in lipid nanodiscs | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytochalasin B, Solute carrier family 2, ... | | Authors: | Yuan, Y, Kong, F, Xu, H, Zhu, A, Yan, N, Yan, C. | | Deposit date: | 2022-01-30 | | Release date: | 2022-05-18 | | Last modified: | 2022-05-25 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Cryo-EM structure of human glucose transporter GLUT4.
Nat Commun, 13, 2022
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7WSN
 | | Cryo-EM structure of human glucose transporter GLUT4 bound to cytochalasin B in detergent micelles | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytochalasin B, Solute carrier family 2, ... | | Authors: | Yuan, Y, Kong, F, Xu, H, Zhu, A, Yan, N, Yan, C. | | Deposit date: | 2022-01-30 | | Release date: | 2022-05-18 | | Last modified: | 2022-05-25 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Cryo-EM structure of human glucose transporter GLUT4.
Nat Commun, 13, 2022
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5Z58
 | | Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom. | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | | Authors: | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | | Deposit date: | 2018-01-17 | | Release date: | 2018-09-19 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | Structure of the human activated spliceosome in three conformational states.
Cell Res., 28, 2018
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5Z56
 | | cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom. | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | | Authors: | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | | Deposit date: | 2018-01-17 | | Release date: | 2018-09-19 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (5.1 Å) | | Cite: | Structure of the human activated spliceosome in three conformational states.
Cell Res., 28, 2018
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5Z57
 | | Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstrom | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ALANINE, BUD13 homolog, ... | | Authors: | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | | Deposit date: | 2018-01-17 | | Release date: | 2018-09-19 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (6.5 Å) | | Cite: | Structure of the human activated spliceosome in three conformational states.
Cell Res., 28, 2018
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5YZG
 | | The Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom resolution | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Zhan, X, Yan, C, Zhang, X, Lei, J, Shi, Y. | | Deposit date: | 2017-12-14 | | Release date: | 2018-08-08 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structure of a human catalytic step I spliceosome
Science, 359, 2018
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5ZWO
 | | Cryo-EM structure of the yeast B complex at average resolution of 3.9 angstrom | | Descriptor: | 13 kDa ribonucleoprotein-associated protein, 23 kDa U4/U6.U5 small nuclear ribonucleoprotein component, 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component, ... | | Authors: | Bai, R, Wan, R, Yan, C, Shi, Y. | | Deposit date: | 2018-05-16 | | Release date: | 2018-08-29 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation
Science, 360, 2018
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5ZWN
 | | Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.3 angstrom (Part II: U1 snRNP region) | | Descriptor: | 56 kDa U1 small nuclear ribonucleoprotein component, Pre-mRNA-processing factor 39, Pre-mRNA-splicing ATP-dependent RNA helicase PRP28, ... | | Authors: | Bai, R, Wan, R, Yan, C, Lei, J, Shi, Y. | | Deposit date: | 2018-05-16 | | Release date: | 2018-08-29 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation
Science, 360, 2018
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5ZWM
 | | Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.4~4.6 angstrom (tri-snRNP and U2 snRNP Part) | | Descriptor: | 13 kDa ribonucleoprotein-associated protein, 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component, Cold sensitive U2 snRNA suppressor 1, ... | | Authors: | Bai, R, Wan, R, Yan, C, Lei, J, Shi, Y. | | Deposit date: | 2018-05-16 | | Release date: | 2018-08-29 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation
Science, 360, 2018
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6AH0
 | | The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex) | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | Authors: | Zhan, X, Yan, C, Zhang, X, Shi, Y. | | Deposit date: | 2018-08-15 | | Release date: | 2018-11-14 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (5.7 Å) | | Cite: | Structures of the human pre-catalytic spliceosome and its precursor spliceosome.
Cell Res., 28, 2018
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7Y5X
 | | CryoEM structure of PS2-containing gamma-secretase treated with MRK-560 | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y. | | Deposit date: | 2022-06-17 | | Release date: | 2022-11-02 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.
Nat Commun, 13, 2022
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7Y5T
 | | CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560 | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y. | | Deposit date: | 2022-06-17 | | Release date: | 2022-11-02 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.
Nat Commun, 13, 2022
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7Y5Z
 | | CryoEM structure of human PS2-containing gamma-secretase | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y. | | Deposit date: | 2022-06-18 | | Release date: | 2022-11-02 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.
Nat Commun, 13, 2022
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6ID1
 | | Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolution | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | | Deposit date: | 2018-09-07 | | Release date: | 2019-03-13 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Structures of the human spliceosomes before and after release of the ligated exon.
Cell Res., 29, 2019
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6ID0
 | | Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | | Deposit date: | 2018-09-07 | | Release date: | 2019-03-13 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structures of the human spliceosomes before and after release of the ligated exon.
Cell Res., 29, 2019
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6ICZ
 | | Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | | Deposit date: | 2018-09-07 | | Release date: | 2019-03-13 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structures of the human spliceosomes before and after release of the ligated exon.
Cell Res., 29, 2019
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6J6H
 | | Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom | | Descriptor: | ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | | Deposit date: | 2019-01-15 | | Release date: | 2019-04-24 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell, 177, 2019
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6J6N
 | | Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | | Deposit date: | 2019-01-15 | | Release date: | 2019-04-24 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (3.86 Å) | | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell, 177, 2019
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