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4YND
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BU of 4ynd by Molmil
The Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2
Descriptor: N-cyclohexyl-N~3~-[2-(3,4-dichlorophenyl)ethyl]-N-(2-{[(2R)-2-hydroxy-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}ethyl)-beta-alaninamide, N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ...
Authors:Sweis, R.F, Wang, Z, Algire, M, Arrowsmith, C.H, Brown, P.J, Chiang, G.C, Guo, J, Jakob, C.G, Kennedy, S, Li, F, Soni, N.B, Vedadi, M, Pappano, W.N.
Deposit date:2015-03-09
Release date:2015-05-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.
Acs Med.Chem.Lett., 6, 2015
4YR9
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BU of 4yr9 by Molmil
mouse TDH with NAD+ bound
Descriptor: GLYCEROL, L-threonine 3-dehydrogenase, mitochondrial, ...
Authors:He, C, Li, F.
Deposit date:2015-03-14
Release date:2016-02-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights on mouse l-threonine dehydrogenase: A regulatory role of Arg180 in catalysis
J.Struct.Biol., 192, 2015
7UFK
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BU of 7ufk by Molmil
Crystal structure of chimeric omicron RBD (strain BA.2) complexed with human ACE2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, W, Shi, K, Geng, Q, Ye, G, Aihara, H, Li, F.
Deposit date:2022-03-22
Release date:2022-10-19
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variant.
Proc.Natl.Acad.Sci.USA, 119, 2022
7UFL
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BU of 7ufl by Molmil
Crystal structure of chimeric omicron RBD (strain BA.2) complexed with chimeric mouse ACE2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, W, Shi, K, Geng, Q, Ye, G, Aihara, H, Li, F.
Deposit date:2022-03-22
Release date:2022-10-19
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variant.
Proc.Natl.Acad.Sci.USA, 119, 2022
8GY6
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BU of 8gy6 by Molmil
Structure of SARS-CoV-2 RNA-dependent RNA polymerase with gossypol binding
Descriptor: Gossypol, Non-structural protein 7, Non-structural protein 8, ...
Authors:Wang, W, Ren, M, Li, F.
Deposit date:2022-09-21
Release date:2023-11-01
Method:ELECTRON MICROSCOPY
Cite:Structure of SARS-CoV-2 RNA-dependent RNA polymerase with gossypol binding
To Be Published
4YRA
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BU of 4yra by Molmil
mouse TDH in the apo form
Descriptor: L-threonine 3-dehydrogenase, mitochondrial
Authors:He, C, Li, F.
Deposit date:2015-03-14
Release date:2016-02-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural insights on mouse l-threonine dehydrogenase: A regulatory role of Arg180 in catalysis
J.Struct.Biol., 192, 2015
7TGY
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BU of 7tgy by Molmil
Prototypic SARS-CoV-2 G614 spike (closed form)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Ye, G, Liu, B, Li, F.
Deposit date:2022-01-09
Release date:2022-03-09
Last modified:2022-03-16
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Cryo-EM structure of a SARS-CoV-2 omicron spike protein ectodomain.
Nat Commun, 13, 2022
7TGX
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BU of 7tgx by Molmil
Prototypic SARS-CoV-2 G614 spike (open form)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, alpha-D-mannopyranose, ...
Authors:Ye, G, Liu, B, Li, F.
Deposit date:2022-01-09
Release date:2022-03-09
Last modified:2022-03-16
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of a SARS-CoV-2 omicron spike protein ectodomain.
Nat Commun, 13, 2022
7U0N
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BU of 7u0n by Molmil
Crystal structure of chimeric omicron RBD (strain BA.1) complexed with human ACE2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Geng, Q, Shi, K, Ye, G, Zhang, W, Aihara, H, Li, F.
Deposit date:2022-02-18
Release date:2022-03-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structural Basis for Human Receptor Recognition by SARS-CoV-2 Omicron Variant BA.1.
J.Virol., 96, 2022
2LS3
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BU of 2ls3 by Molmil
1H Chemical Shift Assignments for the secondary transmembrane domain from human copper transport 1
Descriptor: High affinity copper uptake protein 1
Authors:Yang, L, Huang, Z, Li, F.
Deposit date:2012-04-20
Release date:2012-06-06
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural insights into the transmembrane domains of human copper transporter 1
To be Published
2LS4
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BU of 2ls4 by Molmil
1H Chemical Shift Assignments for the third transmembrane domain from the human copper transport 1
Descriptor: High affinity copper uptake protein 1
Authors:Yang, L, Huang, Z, Li, F.
Deposit date:2012-04-20
Release date:2012-06-06
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural insights into the transmembrane domains of human copper transporter 1
To be Published
2LS2
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BU of 2ls2 by Molmil
1H Chemical Shift Assignments for the first transmembrane domain from human copper transport 1
Descriptor: High affinity copper uptake protein 1
Authors:Yang, L, Huang, Z, Li, F.
Deposit date:2012-04-20
Release date:2012-06-06
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural insights into the transmembrane domains of human copper transporter 1
To be Published
5GJU
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BU of 5gju by Molmil
DEAD-box RNA helicase
Descriptor: ADENOSINE MONOPHOSPHATE, ATP-dependent RNA helicase DeaD
Authors:Xu, L, Li, F, Wang, L, Shi, Y.
Deposit date:2016-07-02
Release date:2017-05-31
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Insights into the Structure of Dimeric RNA Helicase CsdA and Indispensable Role of Its C-Terminal Regions.
Structure, 25, 2017
5GMV
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BU of 5gmv by Molmil
LC3B-FUNDC1 complex
Descriptor: Microtubule-associated proteins 1A/1B light chain 3B, Peptide from FUN14 domain-containing protein 1
Authors:Lv, M, Wang, C, Li, F.
Deposit date:2016-07-17
Release date:2017-03-08
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy
Protein Cell, 8, 2017
5VST
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BU of 5vst by Molmil
Crystal structure of murine CEACAM1b
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Biliary glycoprotein
Authors:Peng, G, Yang, Y, Pasquarella, J.R, Xu, L, Qian, Z, Holmes, K.V, Li, F.
Deposit date:2017-05-12
Release date:2017-05-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular mechanism for coronavirus-driven evolution of mouse receptor
J. Biol. Chem., 292, 2017
8T5I
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BU of 8t5i by Molmil
Crystal structure of human WDR5 in complex with MR4397
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, N-[(2S)-1-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-oxopentan-2-yl]-3-[(1H-imidazol-1-yl)methyl]benzamide, ...
Authors:Kimani, S, Dong, A, Li, F, Loppnau, P, Ackloo, S, Vedadi, M, Brown, P.J, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2023-06-13
Release date:2023-08-09
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of human WDR5 in complex with MR4397
To be published
5WWW
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BU of 5www by Molmil
Crystal structure of the KH1 domain of human RNA-binding E3 ubiquitin-protein ligase MEX-3C complex with RNA
Descriptor: RNA (5'-R(*GP*UP*UP*UP*AP*G)-3'), RNA-binding E3 ubiquitin-protein ligase MEX3C
Authors:Yang, L, Wang, C, Li, F, Gong, Q.
Deposit date:2017-01-05
Release date:2017-08-23
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity
J. Biol. Chem., 292, 2017
5WWZ
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BU of 5wwz by Molmil
Crystal structure of the KH2 domain of human RNA-binding E3 ubiquitin-protein ligase MEX-3C
Descriptor: RNA-binding E3 ubiquitin-protein ligase MEX3C, SULFATE ION
Authors:Yang, L, Wang, C, Li, F, Gong, Q.
Deposit date:2017-01-05
Release date:2017-08-23
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity
J. Biol. Chem., 292, 2017
5WWX
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BU of 5wwx by Molmil
Crystal structure of the KH2 domain of human RNA-binding E3 ubiquitin-protein ligase MEX-3C complex with RNA
Descriptor: NICKEL (II) ION, RNA (5'-R(P*AP*GP*AP*GP*U)-3'), RNA-binding E3 ubiquitin-protein ligase MEX3C
Authors:Yang, L, Wang, C, Li, F, Gong, Q.
Deposit date:2017-01-05
Release date:2017-08-23
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity
J. Biol. Chem., 292, 2017
5GI4
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BU of 5gi4 by Molmil
DEAD-box RNA helicase
Descriptor: ATP-dependent RNA helicase DeaD
Authors:Xu, L, Wang, L, Li, F, Wu, L, Shi, Y.
Deposit date:2016-06-22
Release date:2017-05-31
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.244 Å)
Cite:Insights into the Structure of Dimeric RNA Helicase CsdA and Indispensable Role of Its C-Terminal Regions.
Structure, 25, 2017
5JCP
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BU of 5jcp by Molmil
RhoGAP domain of ARAP3 in complex with RhoA in the transition state
Descriptor: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3,Linker,Transforming protein RhoA, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bao, H, Li, F, Wang, C, Wang, N, Jiang, Y, Tang, Y, Wu, J, Shi, Y.
Deposit date:2016-04-15
Release date:2016-06-22
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3
J.Biol.Chem., 291, 2016
5Y1U
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BU of 5y1u by Molmil
Crystal structure of RBBP4 bound to AEBP2 RRK motif
Descriptor: Histone-binding protein RBBP4, SULFATE ION, Zinc finger protein AEBP2
Authors:Sun, A, Li, F, Wu, J, Shi, Y.
Deposit date:2017-07-21
Release date:2018-04-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.141 Å)
Cite:Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4
Protein Cell, 2017
5YYZ
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BU of 5yyz by Molmil
Crystal structure of the MEK1 FHA domain in complex with the HOP1 pThr318 peptide.
Descriptor: Meiosis-specific protein HOP1, Meiosis-specific serine/threonine-protein kinase MEK1
Authors:Xie, C, Li, F, Jiang, Y, Wu, J, Shi, Y.
Deposit date:2017-12-11
Release date:2018-10-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Structural insights into the recognition of phosphorylated Hop1 by Mek1
Acta Crystallogr D Struct Biol, 74, 2018
5Z4D
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BU of 5z4d by Molmil
Structure of Tailor in complex with AGUU RNA
Descriptor: RNA (5'-R(*AP*GP*UP*U)-3'), Terminal uridylyltransferase Tailor
Authors:Cheng, L, Li, F, Jiang, Y, Yu, H, Xie, C, Shi, Y, Gong, Q.
Deposit date:2018-01-11
Release date:2018-10-31
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.
Nucleic Acids Res., 47, 2019
5Z4M
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BU of 5z4m by Molmil
Structure of TailorD343A with bound UTP and Mg
Descriptor: MAGNESIUM ION, Terminal uridylyltransferase Tailor, URIDINE 5'-TRIPHOSPHATE
Authors:Cheng, L, Li, F, Jiang, Y, Yu, H, Xie, C, Shi, Y, Gong, Q.
Deposit date:2018-01-11
Release date:2018-10-31
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.
Nucleic Acids Res., 47, 2019

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數據於2024-06-19公開中

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